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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch



Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice
V. G. Volpi, C. Ferri, I. Fregno, U. Del Carro, F. Bianchi, C. Scapin, E. Pettinato, T. Solda, M. L. Feltri, M. Molinari, L. Wrabetz, M. D'Antonio
in PLoS Genet (2019) vol. 15 ppe1008069

DDR1 role in fibrosis and its pharmacological targeting
S. Moll, A. Desmouliere, M. J. Moeller, J. C. Pache, L. Badi, F. Arcadu, H. Richter, A. Satz, S. Uhles, A. Cavalli, F. Drawnel, L. Scapozza, M. Prunotto
in Biochim Biophys Acta Mol Cell Res (2019) ppS0167-4889(19)30075-8

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
C. Niogret, S. M. S. Miah, G. Rota, N. P. Fonta, H. Wang, W. Held, W. Birchmeier, V. Sexl, W. Yang, E. Vivier, P. C. Ho, L. Brossay, G. Guarda
in Nat Commun (2019) vol. 10 pp1444

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation
F. Sparber, C. De Gregorio, S. Steckholzer, F. M. Ferreira, T. Dolowschiak, F. Ruchti, F. R. Kirchner, S. Mertens, I. Prinz, N. Joller, T. Buch, M. Glatz, F. Sallusto, S. LeibundGut-Landmann
in Cell Host Microbe (2019) vol. 25 pp389-403 e6
free pdf: https://www.sciencedirect.com/science/article/pii/S1931312819300629?dgcid=coauthor

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
J. Marcandalli, B. Fiala, S. Ols, M. Perotti, W. de van der Schueren, J. Snijder, E. Hodge, M. Benhaim, R. Ravichandran, L. Carter, W. Sheffler, L. Brunner, M. Lawrenz, P. Dubois, A. Lanzavecchia, F. Sallusto, K. K. Lee, D. Veesler, C. E. Correnti, L. J. Stewart, D. Baker, K. Lore, L. Perez, N. P. King
in Cell (2019) vol. 176 pp1420-1431 e17
* J. Marcandalli and B. Fiala contributed equally to this work. L. Perez and N. P. King contributed equally to this work and are co-corresponding authors.

Seeing is believing: DNA zipping promotes DNA repair
P. Cejka
in J Biol Chem (2019) vol. 294 pp3321-3322

Stepwise 5' DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble
E. Cannavo, G. Reginato, P. Cejka
in Proc Natl Acad Sci U S A (2019) vol. 116 pp5505-5513

Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez
in Cell Rep (2019) vol. 26 pp2307-2315 e5

DNA (Hydroxy)Methylation in T Helper Lymphocytes
S. Monticelli
in Trends Biochem Sci (2019) pp S0968-0004(19)30018-0

Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations
J. Lee, P. Paparoditis, A. P. Horton, A. Fruhwirth, J. R. McDaniel, J. Jung, D. R. Boutz, D. A. Hussein, Y. Tanno, L. Pappas, G. C. Ippolito, D. Corti, A. Lanzavecchia, G. Georgiou
in Cell Host Microbe (2019) vol. 13 pp367-376

NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation
R. Anand, A. Jasrotia, D. Bundschuh, S. M. Howard, L. Ranjha, M. Stucki, P. Cejka
in EMBO J (2019) vol. 38 ppe101005

Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
M. Palomino-Segura, S. F. Gonzalez
in Methods Mol Biol (2019) vol. 1968 pp183-194

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
A. C. Walls, X. Xiong, Y. J. Park, M. A. Tortorici, J. Snijder, J. Quispe, E. Cameroni, R. Gopal, M. Dai, A. Lanzavecchia, M. Zambon, F. A. Rey, D. Corti, D. Veesler
in Cell (2019) vol. 176 pp1026-1039

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent
L. Vincenzetti, C. Leoni, M. Chirichella, I. Kwee, S. Monticelli
in Eur J Immunol (2019) vol. 49 pp611-625

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus
C. E. Faliti, R. Gualtierotti, E. Rottoli, M. Gerosa, L. Perruzza, A. Romagnani, G. Pellegrini, B. De Ponte Conti, R. L. Rossi, M. Idzko, E. M. C. Mazza, S. Bicciato, E. Traggiai, P. L. Meroni, F. Grassi
in J Exp Med (2019) vol. 216 pp317-336

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
M. Proietti, L. Perruzza, D. Scribano, G. Pellegrini, R. D'Antuono, F. Strati, M. Raffaelli, S. F. Gonzalez, M. Thelen, W. D. Hardt, E. Slack, M. Nicoletti, F. Grassi
in Nat Commun (2019) vol. 10 pp250

Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system
A. S. Cordeiro, J. Crecente-Campo, B. Lopez-Bouzo, S. F. Gonzalez, M. de la Fuente, M. J. Alonso
in J Drug Target (2019) pp1-52

A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex
A. Forrester, C. De Leonibus, P. Grumati, E. Fasana, M. Piemontese, L. Staiano, I. Fregno, A. Raimondi, A. Marazza, G. Bruno, M. Iavazzo, D. Intartaglia, M. Seczynska, E. van Anken, I. Conte, M. A. De Matteis, I. Dikic, M. Molinari, C. Settembre
in EMBO J (2019) vol. 38 ppe99847

Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study
P. E. H. Jensen, C. Warnke, K. Ingenhoven, L. Piccoli, M. Gasis, C. Hermanrud, B. M. Fernandez-Rodriguez, M. Ryner, D. Kramer, J. Link, R. Ramanujam, M. Auer, D. Buck, V. Grummel, E. Bertotti, N. Fissolo, B. Oliver-Martos, P. Nytrova, M. Khalil, M. Guger, S. Rathmaier, C. Sievers-Stober, R. L. P. Lindberg, S. Hassler, D. Bachelet, O. Aktas, N. Donnellan, A. Lawton, B. Hemmer, E. K. Havrdova, B. Kieseier, H. P. Hartung, M. Comabella, X. Montalban, T. Derfuss, F. Sellebjerg, P. Donnes, M. Pallardy, S. Spindeldreher, P. Broet, F. Deisenhammer, A. Fogdell-Hahn, P. S. Sorensen, Abirisk Consortium
in J Neuroimmunol (2019) vol. 326 pp19-27

Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
M. Palomino-Segura, S. Gonzalez F.
Federico Iovino
in Streptococcus pneumoniae (2019) ppVIII, 212