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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch



AncesTree: An interactive immunoglobulin lineage tree visualizer
M. Foglierini, L. Pappas, A. Lanzavecchia, D. Corti, L. Perez
in PLoS Comput Biol (2020) vol. 16 ppe1007731

Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin
A. Cassotta, P. Paparoditis, R. Geiger, R. R. Mettu, S. J. Landry, A. Donati, M. Benevento, M. Foglierini, D. J. M. Lewis, A. Lanzavecchia, F. Sallusto
in J Exp Med (2020) vol. 217

Dynamics in protein translation sustaining T cell preparedness
T. Wolf, W. Jin, G. Zoppi, I. A. Vogel, M. Akhmedov, C. K. E. Bleck, T. Beltraminelli, J. C. Rieckmann, N. J. Ramirez, M. Benevento, S. Notarbartolo, D. Bumann, F. Meissner, B. Grimbacher, M. Mann, A. Lanzavecchia, F. Sallusto, I. Kwee, R. Geiger
in Nat Immunol (2020)

The P2X7 Receptor as Regulator of T Cell Development and Function
F. Grassi
in Front Immunol (2020) vol. 11 pp1179

Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection
L. Perruzza, S. Jaconi, G. Lombardo, D. Pinna, F. Strati, D. Morone, F. Seehusen, Y. Hu, S. Bajoria, J. Xiong, O. S. Kumru, S. B. Joshi, D. B. Volkin, R. Piantanida, F. Benigni, F. Grassi, D. Corti, M. S. Pizzuto
in Front Immunol (2020) vol. 11 pp1011

The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2
L. Mariotti, S. Wild, G. Brunoldi, A. Piceni, I. Ceppi, S. Kummer, R. E. Lutz, P. Cejka, K. Gari
in Commun Biol (2020) vol. 3 pp322

CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4
C. Matti, G. D'Uonnolo, M. Artinger, S. Melgrati, A. Salnikov, S. Thelen, V. Purvanov, T. D. Strobel, L. Spannagel, M. Thelen, D. F. Legler
in J Leukoc Biol (2020) vol. 107 pp1137-1154

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
J. W. Huang, A. Acharya, A. Taglialatela, T. S. Nambiar, R. Cuella-Martin, G. Leuzzi, S. B. Hayward, S. A. Joseph, G. J. Brunette, R. Anand, R. K. Soni, N. L. Clark, K. A. Bernstein, P. Cejka, A. Ciccia
in Nat Commun (2020) vol. 11 pp2948

Phosphorylation of the RecQ Helicase Sgs1/BLM Controls Its DNA Unwinding Activity during Meiosis and Mitosis
R. Grigaitis, L. Ranjha, P. Wild, K. Kasaciunaite, I. Ceppi, V. Kissling, A. Henggeler, A. Susperregui, M. Peter, R. Seidel, P. Cejka, J. Matos
in Dev Cell (2020)

Different hierarchies of anti-modified protein autoantibody reactivities in rheumatoid arthritis
P. Sahlstrom, M. Hansson, J. Steen, K. Amara, P. J. Titcombe, B. Forsstrom, R. Stalesen, L. Israelsson, L. Piccoli, K. Lundberg, L. Klareskog, D. L. Mueller, A. I. Catrina, K. Skriner, V. Malmstrom, C. Gronwall
in Arthritis Rheumatol (2020)

ER-phagy: Eating the Factory
M. Molinari
in Mol Cell (2020) vol. 78 pp811-813

The MRE11 complex: A versatile toolkit for the repair of broken DNA
G. Reginato, P. Cejka
in DNA Repair (Amst) (2020) vol. 91-92 pp102869

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
D. Pinto, Y. J. Park, M. Beltramello, A. C. Walls, M. A. Tortorici, S. Bianchi, S. Jaconi, K. Culap, F. Zatta, A. De Marco, A. Peter, B. Guarino, R. Spreafico, E. Cameroni, J. B. Case, R. E. Chen, C. Havenar-Daughton, G. Snell, A. Telenti, H. W. Virgin, A. Lanzavecchia, M. S. Diamond, K. Fink, D. Veesler, D. Corti
in Nature (2020)

Deep learning approach for quantification of organelles and misfolded polypeptides delivery within degradative compartments
D. Morone, A. Marazza, T. J. Bergmann, M. Molinari
in Mol Biol Cell (2020) ppmbcE20040269

ACKR4 Recruits GRK3 Prior to beta-Arrestins but Can Scavenge Chemokines in the Absence of beta-Arrestins
C. Matti, A. Salnikov, M. Artinger, G. D'Agostino, I. Kindinger, M. Uguccioni, M. Thelen, D. F. Legler
in Front Immunol (2020) vol. 11 pp720

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532)
M. Montopoli, S. Zumerle, R. Vettor, M. Rugge, M. Zorzi, C. V. Catapano, G. M. Carbone, A. Cavalli, F. Pagano, E. Ragazzi, T. Prayer-Galetti, A. Alimonti
in Ann Oncol (2020)

The internal region of CtIP negatively regulates DNA end resection
S. M. Howard, I. Ceppi, R. Anand, R. Geiger, P. Cejka
in Nucleic Acids Res (2020)

How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs
M. Garofalo, G. Grazioso, A. Cavalli, J. Sgrignani
in Molecules (2020) vol. 25 pppii: E1756

CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
I. Ceppi, S. M. Howard, K. Kasaciunaite, C. Pinto, R. Anand, R. Seidel, P. Cejka
in Proc Natl Acad Sci U S A (2020) vol. 117 pp8859-8869

A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes
S. Emming, N. Bianchi, S. Polletti, C. Balestrieri, C. Leoni, S. Montagner, M. Chirichella, N. Delaleu, G. Natoli, S. Monticelli
in Nat Immunol (2020) vol. 21 pp388-399

Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import
S. Schorr, D. Nguyen, S. Hassdenteufel, N. Nagaraj, A. Cavalie, M. Greiner, P. Weissgerber, M. Loi, A. W. Paton, J. C. Paton, M. Molinari, F. Forster, J. Dudek, S. Lang, V. Helms, R. Zimmermann
in FEBS J (2020)

Regulated Proteolysis of MutSgamma Controls Meiotic Crossing Over
W. He, Hbdp Rao, S. Tang, N. Bhagwat, D. S. Kulkarni, Y. Ma, M. A. W. Chang, C. Hall, J. W. Bragg, H. S. Manasca, C. Baker, G. F. Verhees, L. Ranjha, X. Chen, N. M. Hollingsworth, P. Cejka, N. Hunter
in Mol Cell (2020) vol. 78 pp168-183 e5

Human CD4(+) T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
H. Nishihara, S. Soldati, A. Mossu, M. Rosito, H. Rudolph, W. A. Muller, D. Latorre, F. Sallusto, M. Sospedra, R. Martin, H. Ishikawa, T. Tenenbaum, H. Schroten, F. Gosselet, B. Engelhardt
in Fluids Barriers CNS (2020) vol. 17 pp3

Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress
M. Loi, M. Molinari
in Autophagy (2020) vol. 16 pp385-386

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis
N. Haghayegh Jahromi, L. Marchetti, F. Moalli, D. Duc, C. Basso, H. Tardent, E. Kaba, U. Deutsch, Caroline Pot, F. Sallusto, J. V. Stein, B. Engelhardt
in Frontiers in Immunology (2020) vol. 10 pp3056

Rebound of disease activity after fingolimod withdrawal: Immunological and gene expression profiling
R. Sacco, S. Emming, C. Gobbi, C. Zecca, S. Monticelli
in Mult Scler Relat Disord (2020) vol. 40 pp101927

Endoplasmic Reticulum and Lysosomal Quality Control of Four Nonsense Mutants of Iduronate 2-Sulfatase Linked to Hunter's Syndrome
A. Marazza, C. Galli, E. Fasana, J. Sgrignani, P. Burda, E. M. A. Fassi, M. Baumgartner, A. Cavalli, M. Molinari
in DNA Cell Biol (2020) vol. 39 pp226-234

Zinc(ii)-mediated diastereoselective Passerini reactions of biocatalytically desymmetrised renewable inputs
L. Moni, L. Banfi, D. Cartagenova, A. Cavalli, C. Lambruschini, E. Martino, R. V. A. Orru, E. Ruijter, J. M. Saya, J. Sgrignani, R. Riva
in Organic Chemistry Frontiers (2020)