Simonelli Luca, PhD

Publications

• Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
  Bianchini, F. Crivelli, V. Abernathy, M. E. Guerra, C. Palus, M. Muri, J. Marcotte, H. Piralla, A. Pedotti, M. De Gasparo, R. Simonelli, L. Matkovic, M. Toscano, C. Biggiogero, M. Calvaruso, V. Svoboda, P. Cervantes Rincon, T. Fava, T. Podesvova, L. Shanbhag, A. A. Celoria, A. Sgrignani, J. Stefanik, M. Honig, V. Pranclova, V. Michalcikova, T. Prochazka, J. Guerrini, G. Mehn, D. Ciabattini, A. Abolhassani, H. Jarrossay, D. Uguccioni, M. Medaglini, D. Pan-Hammarstrom, Q. Calzolai, L. Fernandez, D. Baldanti, F. Franzetti-Pellanda, A. Garzoni, C. Sedlacek, R. Ruzek, D. Varani, L. Cavalli, A. Barnes, C. O. Robbiani, D. F.
  in Sci Immunol (2023) Vol. ppeade0958
  
• A conformational switch controlling the toxicity of the prion protein
  Frontzek, K. Bardelli, M. Senatore, A. Henzi, A. Reimann, R. R. Bedir, S. Marino, M. Hussain, R. Jurt, S. Meisl, G. Pedotti, M. Mazzola, F. Siligardi, G. Zerbe, O. Losa, M. Knowles, T. Lakkaraju, A. Zhu, C. Schwarz, P. Hornemann, S. Holt, M. G. Simonelli, L. Varani, L. Aguzzi, A.
  in Nat Struct Mol Biol (2022) Vol.29 pp831-840
  
• Humoral and cell-mediated response elicited by SARS-CoV-2 mRNA vaccine BNT162b2 e in healthcare workers: a longitudinal observational study
  Cassaniti, I. Bergami, F. Percivalle, E. Gabanti, E. Sammartino, J. C. Ferrari, A. Guy Adzasehoun, K. M. Zavaglio, F. Zelini, P. Comolli, G. Sarasini, A. Piralla, A. Ricciardi, A. Zuccaro, V. Maggi, F. Novazzi, F. Simonelli, L. Varani, L. Lilleri, D. Baldanti, F.
  in Clin Microbiol Infect (2021) Vol. pp
  
• Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction
  Sgrignani, J. Cecchinato, V. Fassi, E. M. A. D'Agostino, G. Garofalo, M. Danelon, G. Pedotti, M. Simonelli, L. Varani, L. Grazioso, G. Uguccioni, M. Cavalli, A.
  in J Med Chem (2021) Vol.64 pp13439-13450.
  
• Rational engineering of the lccbeta T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons
  Chiado, A. Bosco, F. Bardelli, M. Simonelli, L. Pedotti, M. Marmo, L. Varani, L.
  in Comput Struct Biotechnol J (2021) Vol.19 pp2213-2222
  
• SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
  Bertoglio, F. Meier, D. Langreder, N. Steinke, S. Rand, U. Simonelli, L. Heine, P. A. Ballmann, R. Schneider, K. T. Roth, K. D. R. Ruschig, M. Riese, P. Eschke, K. Kim, Y. Schackermann, D. Pedotti, M. Kuhn, P. Zock-Emmenthal, S. Wohrle, J. Kilb, N. Herz, T. Becker, M. Grasshoff, M. Wenzel, E. V. Russo, G. Kroger, A. Brunotte, L. Ludwig, S. Fuhner, V. Kramer, S. D. Dubel, S. Varani, L. Roth, G. Cicin-Sain, L. Schubert, M. Hust, M.
  in Nat Com (2021) Vol.12 pp1577
  
• Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
  De Gasparo, R. Pedotti, M. Simonelli, L. Nickl, P. Muecksch, F. Lorenzi, J. C. C. Mazzola, F. Magrì, D. Michalcikova, T. Haviernik, J. Honig, V. Cassaniti, I. Percivalle, E. Mrazkova, B. Polakova,N. Fortova, A. Tureckova, J. Iatsiuk, V. Di Girolamo, S. Palus, P. Zudova, D. Bednar, P. Bukova, I. Bianchini, F. Mehn, D. Nencka, R. Strakova, P. Pavlis, O. Rozman, J. Gioria, S. Sammartino, J. C. Giardina, F. Gaiarsa, S. Hammarström, Q. P. Barnes, C. O. Piralla, A. Bjorkman, P. J. Baldanti, F. Calzolai, L. Nussenzweig, M. C. Bieniasz, P. D. Hatziioannou, T. Prochazka, J. Sedlacek, R. Robbiani, D. F. Ruzek, D. Varani, L.
  in Nature (2021) Vol.593 pp424-428
  
• A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
  Bardelli, M. Frontzek, K. Simonelli, L. Pedotti, M. Mazzola, F. Carta, M. Eckhardt, V. D'Antuono, R. Virgilio, T. Gonzalez, S. F. Aguzzi, A. Varani, L.
  in PLoS Pathog (2018) Vol.14 ppe1007335
  
• Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
  Simonelli, L. Pedotti, M. Bardelli, M. Zerbe, O. Varani, L.
  in Methods Mol Biol (2018) Vol.1785 pp29-51
  
• A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
  Wang, J. Bardelli, M. Espinosa, D. A. Pedotti, M. Ng, T. S. Bianchi, S. Simonelli, L. Lim, E. X. Y. Foglierini, M. Zatta, F. Jaconi, S. Beltramello, M. Cameroni, E. Fibriansah, G. Shi, J. Barca, T. Pagani, I. Rubio, A. Broccoli, V. Vicenzi, E. Graham, V. Pullan, S. Dowall, S. Hewson, R. Jurt, S. Zerbe, O. Stettler, K. Lanzavecchia, A. Sallusto, F. Cavalli, A. Harris, E. Lok, S. M. Varani, L. Corti, D.
  in Cell (2017) Vol.171 pp229-241 e15
  
• Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia
  Arcangeli, S. Rotiroti, M. C. Bardelli, M. Magnani, C. F. Biondi, A. Biagi, E. Tettamanti, S. Varani, L.
  in Mol Ther (2017) Vol.25 pp1933-1945
  
• Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
  Fumagalli, F. Noack, J. Bergmann, T. J. Pisoni, G. B. Fasana, E. Fregno, I. Galli, C. Loi, M. Solda, T. D'Antuono, R. Raimondi, A. Jung, M. Melnyk, A. Schorr, S. Schreiber, A. Simonelli, L. Varani, L. Wilson-Zbinden, C. Zerbe, O. Hofmann, K. Peter, M. Quadroni, M. Zimmermann, R. Molinari, M.
  in Nat Cell Biol (2016) Vol.18 pp1173-1184
  Fumagalli, F. , Noack J. and Bergmann T. contributed equally to this work. * Recommended by the Faculty of 1000
• Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
  Stettler, K. Beltramello, M. Espinosa, D. A. Cassotta, A. Bianchi, S. Vanzetta, F. Minola, A. Jaconi, S. Mele, F. Foglierini, M. Pedotti, M. Simonelli, L. Dowall, S. Atkinson, B. Percivalle, E. Simmons, C. P. Varani, L. Blum, J. Baldanti, F. Cameroni, E. Hewson, R. Harris, E. Lanzavecchia, A. Sallusto, F.Corti, D.
  in Science (2016) Vol.353 pp823-6
  K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
• Antibody Binding Modulates Conformational Exchange in Domain III of Dengue Virus E Protein
  Moraes, A. H. Simonelli, L. Pedotti, M. Varani, L. Valente, A. P.
  in J Virol (2015) Vol.90 pp1802-11
  * Co-corresponding author
• Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables
  Arcangeli, S. Bardelli, M. Tettamanti, S. Simonelli, L. Magnani, C. F. Varani, V. Biondi, A. Biagi, E.
  in 57th ASH Annual Meeting (2015) Vol.126 pp1359
  
• Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
  Corti, D. Zhao, J. Pedotti, M. Agnihothram, S. Fett, C. Fernandez-Rodriguez, B. Foglierini, M. Agatic, G. Vanzetta, F. Gopal, R. Langrish, C. J. Barrett, N. A. Sallusto, F. Baric, R. S. Varani, L. Zambon, M. Perlman, S. Lanzavecchia, A.
  in Proc Natl Acad Sci U S A (2015) Vol.112 pp10473-8
  D.C. and J.Z. contributed equally to this work.
• Epitope mapping by solution NMR spectroscopy
  Bardelli, M. Livoti, E. Simonelli, L. Moraes, A. Valente, A. P. Varani, L.
  in J Mol Recognit (2015) Vol.28 pp393-400
  
• Rational modification of estrogen receptor by combination of computational and experimental analysis
  Ferrero, V. E. Pedotti, M. Chiado, A. Calzolai, L. Lettieri, T. Varani, L.
  in PLoS One (2014) Vol.9 ppe102658
  
• Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
  Simonelli, L. Pedotti, M. Beltramello, M. Calzolai, L. Sallusto, F. Lanzavecchia, A. Varani, L.
  in PLoS One (2013) Vol.8 ppe55561
  Luca Simonelli, Mattia Pedotti contributed equally to this work.
• Computational docking of antibody-antigen complexes, opportunities and pitfalls illustrated by influenza hemagglutinin
  Pedotti, M. Simonelli, L. Livoti, E. Varani, L.
  in Int J Mol Sci (2011) Vol.12 pp226-51
  
• The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
  Beltramello, M. Williams, K. L. Simmons, C. P. Simonelli, L. Quyen, N. T. Sukupolvi-Petty, S. Navarro-Sanchez, E. Young, P. R. de Silva, A. M. Rey, F. A. Varani, L. Whitehead, S. S. Diamond, M. S. Harris, E. Lanzavecchia, A. Sallusto, F.
  in Cell Host Microbe (2010) Vol.8 pp271-83
  Antonio Lanzavecchia and Federica Sallusto are co-corresponding authors.
• Rapid structural characterization of human antibody-antigen complexes through experimentally validated computational docking
  Simonelli, L. Beltramello, M. Yudina, Z. Calzolai, L. Varani, L.
  in J Mol Biol (2010) Vol.396 pp1491-507