Cannavò Cejka Elda, PhD

Publications

• PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection
  Ceppi, I. Cannavo, E. Bret, H. Camarillo, R. Vivalda, F. Thakur, R. S. Romero-Franco, A. Sartori, A. A. Huertas, P. Guerois, R. Cejka, P.
  in Genes Dev (2023) Vol. pp
  
• WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures
  Mengoli, V. Ceppi, I. Sanchez, A. Cannavo, E. Halder, S. Scaglione, S. Gaillard, P. H. McHugh, P. J. Riesen, N. Pettazzoni, P. Cejka, P.
  in EMBO J (2022) Vol. ppe111998
  
• Inhibition of MRN activity by a telomere protein motif
  Khayat, F. Cannavo, E. Alshmery, M. Foster, W. R. Chahwan, C. Maddalena, M. Smith, C. Oliver, A. W. Watson, A. T. Carr, A. M. Cejka, P. Bianchi, A.
  in Nat Commun (2021) Vol.12 pp3856
  
• Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners
  Marsella, A., Gobbini, E., Cassani, C., Tisi, R., Cannavo, E., Reginato, G., Cejka, P., Longhese, M. P.
  in Cell Rep (2021) Vol.34 pp108906
  
• Regulation of the MLH1-MLH3 endonuclease in meiosis
  Cannavo, E. Sanchez, A. Anand, R. Ranjha, L. Hugener, J. Adam, C. Acharya, A. Weyland, N. Aran-Guiu, X. Charbonnier, J. B. Hoffmann, E. R. Borde, V. Matos, J. Cejka, P.
  in Nature (2020) Vol.586 pp618-622
  
• Stepwise 5′ DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble
  Cannavo, E. Reginato, G. Cejka, P.
  in Proc Natl Acad Sci U S A (2019) Vol.116 pp5505-5513
  
• Regulatory control of DNA end resection by Sae2 phosphorylation
  Cannavo, E. Johnson, D. Andres, S. N. Reinert, J. K. Garcia, V. Erie, D. A. Hess, D. Thoma, N. H. Enchev, R. I. Peter, M. Williams, R. S. Neale, M. J. Cejka, P.
  in Nat Commun (2018) Vol.9 pp4016
  
• Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection
  Reginato, G. Cannavo, E. Cejka, P.
  in Genes Dev (2017) Vol.31 pp2325-2330
  
• Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
  Anand, R. Ranjha, L. Cannavo, E.
  in Mol Cell (2016) Vol.64 pp940-950
  
• Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
  Oh, J. Al-Zain, A. Cannavo, E. Symington, L. S.
  in Mol Cell (2016) Vol.64 pp405-415
  
• Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
  Cannavo, E. Cejka, P.
  in Nature (2014) Vol.514 pp122-5
  
• Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection
  Cannavo, E. Cejka, P. Kowalczykowski, S. C.
  in Proc Natl Acad Sci U S A (2013) Vol.110 ppE1661-8
  
• DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
  Cejka, P. Cannavo, E. Polaczek, P. Pokharel, S. Campbell, J. L. Kowalczykowski, S. C.
  in Nature (2010) Vol.467 pp112-6
  
• Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
  Cannavo, E. Marra, G. Sabates-Bellver, J. Lipkin, S. M. Fischer, F. Cejka, P. Jiricny, J.
  in Cancer Res (2005) Vol.65 pp10759-66
  
• Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability
  Cejka, P. Marra, G. Hemmerle, C. Storchova, Z. Jiricny, J.
  in Cancer Res (2003) Vol.63 pp8113-7
  
• Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1
  Cejka, P. Stojic, L. Mojas, N. Heinimann, K. Cannavo, E. di Pietro, M. Marra, G. Jiricny, J.
  in EMBO J (2003) Vol.22 pp2245-54