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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Immune Regulation

Antonio Lanzavecchia, Group Leader

Yiwei Chen, Blanca Maria Fernandez Rodriguez, Josipa Jerak, Michael Kramer, Philipp Paparoditis, Mathilde Foglierini Perez, Isabella Giacchetto - Sasselli

Lanzavecchia’s laboratory investigates the mechanisms of antibody-mediated resistance to infectious diseases. They use high-throughput cellular screens to isolate potent and broadly neutralizing antibodies, which can be developed for prophylaxis and treatment of infectious diseases and used as tools for vaccine design. They also address fundamental aspects of the antibody response, such as the role of somatic mutations in affinity maturation and the relationship between infection and autoimmunity. Recently, they discovered in malaria-immune individuals a new mechanism of antibody diversification that involves insertions of templated DNA sequences into immunoglobulin genes.