Structure Based Nanoparticle Vaccine Design
Research area: Cellular Immunology
- Jessica Marcandalli, Technician
- Laurent Perez, Scientist, Responsible for the protein production Facility
- Michela Perotti, PhD Student
- Federica Sallusto, Group Leader
Status: In progress
Our RSV nanoparticle results motivated us to continue the development of this promising nanoparticle platform for structure-based vaccine design. We are currently combining immune repertoire interrogation, computational design, structural biology and mice immunization to generate the next generation vaccine against different pathogens with no vaccine available. We are also investigating the potential of co-display to generate a broad immune response against pathogens belonging to the same family. Moreover, we are also exploring the potential advantages of antigen and immune activator co-display for nanoparticle self-adjuvantation.