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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Santiago F. González, PhD, PhD

Infection and Immunity

Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland

Bio

Santiago F. González holds two PhD degrees, one in microbiology from the University of Santiago de Compostela (Spain) and one in immunology from the University of Copenhagen (Denmark). From January 2007 to September 2011 he was a postdoc in the group of Michael Carroll at the Immune Disease Institute, Harvard Medical School, in Boston (USA). He has been awarded three EU Marie Curie Fellowships, one for his postgraduate studies in Denmark where he studied skin inflammation and the connection between innate and adaptive responses from a molecular perspective. The second fellowship was a Marie Curie International Outgoing Fellowship awarded in 2008 for a project shared between Harvard Medical School and the National Center for Biotechnology (Madrid). The project focused on the study of the defense mechanism against Influenza virus. The third fellowship is the Marie Curie Career Integration Grant to establish his group at the IRB. He has published several papers related with antigen trafficking, memory B cell, and the regulation of the immune system in high impact journals. During his work at Harvard he studied the transport mechanism of an influenza vaccine in the lymph node. He found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. These results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination and were published in Nature Immunology. In November 2012 he joined the Institute for Research in Biomedicine in Bellinzona as a group leader studying pathogen-host interaction.

 

* INIMIN, a success story

Così il virus dell’influenza può essere bloccato appena entra

Projects
Role of neutrophils in the immune response to virus and bacteria
Characterization of the inflammatory reaction caused by influenza virus
Publications
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1
M. Palomino-Segura, L. Perez, Y. Farsakoglu, T. Virgilio, I. Latino, R. D'Antuono, N. Chatziandreou, D. U. Pizzagalli, G. Wang, A. Garcia-Sastre, F. Sallusto, M. C. Carroll, O. Neyrolles, S. F. Gonzalez
in Nat Microbiol (2019)
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez
in Cell Rep (2019) vol. 26 pp2307-2315 e5
Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
M. Palomino-Segura, S. F. Gonzalez
in Methods Mol Biol (2019) vol. 1968 pp183-194
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
M. Proietti, L. Perruzza, D. Scribano, G. Pellegrini, R. D'Antuono, F. Strati, M. Raffaelli, S. F. Gonzalez, M. Thelen, W. D. Hardt, E. Slack, M. Nicoletti, F. Grassi
in Nat Commun (2019) vol. 10 pp250
Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system
A. S. Cordeiro, J. Crecente-Campo, B. Lopez-Bouzo, S. F. Gonzalez, M. de la Fuente, M. J. Alonso
in J Drug Target (2019) pp1-52
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
M. Bardelli, K. Frontzek, L. Simonelli, S. Hornemann, M. Pedotti, F. Mazzola, M. Carta, V. Eckhardt, R. D'Antuono, T. Virgilio, S. F. Gonzalez, A. Aguzzi, L. Varani
in PLoS Pathog (2018) vol. 14 ppe1007335
Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
M. Palomino-Segura, T. Virgilio, D. Morone, Diego. U. Pizzagalli, S. Gonzalez F.
in JoVE (2018) ppe58355
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
D. U. Pizzagalli, Y. Farsakoglu, M. Palomino-Segura, E. Palladino, J. Sintes, F. Marangoni, T. R. Mempel, W. H. Koh, T. T. Murooka, F. Thelen, J. V. Stein, G. Pozzi, M. Thelen, R. Krause, S. F. Gonzalez
in Sci Data (2018) vol. 5 pp180129
Epithelial-Mesenchymal transition in cancer metastasis through the lymphatic system
M. C. Karlsson, S. F. Gonzalez, J. Welin, J. Fuxe
in Mol Oncol (2017) vol. 11 pp781-791
Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node
N. Chatziandreou, Y. Farsakoglu, M. Palomino-Segura, R. D'Antuono, D. U. Pizzagalli, F. Sallusto, V. Lukacs-Kornek, M. Uguccioni, D. Corti, S. J. Turley, A. Lanzavecchia, M. C. Carroll, S. F. Gonzalez
in Cell Rep (2017) vol. 18 pp2427-2440
Dynamic intravital imaging of cell-cell interactions in the lymph node
J. V. Stein, S. F. Gonzalez
in J Allergy Clin Immunol (2017) vol. 139 pp12-20
Development of a SYBR green I real-time PCR assay for specific identification of the fish pathogen Aeromonas salmonicida subspecies salmonicida
C. Fernandez-Alvarez, S. F. Gonzalez, Y. Santos
in Appl Microbiol Biotechnol (2016) vol. 100 pp10585-10595
Antibody-Mediated Immunity
N. Baumgarth, M. C. Carroll, S. F. Gonzalez
John Wiley & Sons
in Textbook of Influenza, 2nd Edition (2013)
Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
B. A. Heesters, P. Chatterjee, Y. A. Kim, S. F. Gonzalez, M. P. Kuligowski, T. Kirchhausen, M. C. Carroll
in Immunity (2013) vol. 38 pp1164-75
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
B. F. Py, S. F. Gonzalez, K. Long, M. S. Kim, Y. A. Kim, H. Zhu, J. Yao, N. Degauque, R. Villet, P. Ymele-Leki, M. Gadjeva, G. B. Pier, M. C. Carroll, J. Yuan
in Immunity (2013) vol. 38 pp1063-72
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2
S. E. Acton, J. L. Astarita, D. Malhotra, V. Lukacs-Kornek, B. Franz, P. R. Hess, Z. Jakus, M. Kuligowski, A. L. Fletcher, K. G. Elpek, A. Bellemare-Pelletier, L. Sceats, E. D. Reynoso, S. F. Gonzalez, D. B. Graham, J. Chang, A. Peters, M. Woodruff, Y. A. Kim, W. Swat, T. Morita, V. Kuchroo, M. C. Carroll, M. L. Kahn, K. W. Wucherpfennig, S. J. Turley
in Immunity (2012) vol. 37 pp276-89
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
D. Malhotra, A. L. Fletcher, J. Astarita, V. Lukacs-Kornek, P. Tayalia, S. F. Gonzalez, K. G. Elpek, S. K. Chang, K. Knoblich, M. E. Hemler, M. B. Brenner, M. C. Carroll, D. J. Mooney, S. J. Turley
in Nat Immunol (2012) vol. 13 pp499-510
Molecular cloning and expression of two beta-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after beta-glucan feeding
Mv Marel, M. Adamek, S. F. Gonzalez, P. Frost, J. H. Rombout, G. F. Wiegertjes, H. F. Savelkoul, D. Steinhagen
in Fish Shellfish Immunol (2012) vol. 32 pp494-501
Trafficking of B cell antigen in lymph nodes
S. F. Gonzalez, S. E. Degn, L. A. Pitcher, M. Woodruff, B. A. Heesters, M. C. Carroll
in Annu Rev Immunol (2011) vol. 29 pp215-33
The role of innate immunity in B cell acquisition of antigen within LNs
S. F. Gonzalez, M. P. Kuligowski, L. A. Pitcher, R. Roozendaal, M. C. Carroll
in Adv Immunol (2010) vol. 106 pp1-19
Complement-dependent transport of antigen into B cell follicles
S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, L. A. Pitcher, S. E. Degn, S. J. Turley, M. C. Carroll
in J Immunol (2010) vol. 185 pp2659-64
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes
S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, L. A. Pitcher, S. E. Degn, Y. A. Kim, M. J. Cloninger, L. Martinez-Pomares, S. Gordon, S. J. Turley, M. C. Carroll
in Nat Immunol (2010) vol. 11 pp427-34
SIGN-R1-expressing dendritic cells are important for humoral immunity to influenza virus
L. A. Pitcher, S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, Y. A. Kim, L. Martinez-Pomares, S. Gordon, S. J. Turley, M. C. Carroll
in Mol Immunol (2010) vol. 47 pp2227-2227
The role of the complement system in trafficking of a Streptococcus vaccine in the lymph node
B. A. Heesters, S. F. Gonzalez, M. C. Carroll
in Mol Immunol (2010) vol. 47 pp2249-2249
B cell acquisition of antigen in vivo
S. F. Gonzalez, L. A. Pitcher, T. Mempel, F. Schuerpf, M. C. Carroll
in Curr Opin Immunol (2009) vol. 21 pp251-7
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
R. Roozendaal, T. R. Mempel, L. A. Pitcher, S. F. Gonzalez, A. Verschoor, R. E. Mebius, U. H. von Andrian, M. C. Carroll
in Immunity (2009) vol. 30 pp264-76
Serological methods for the detection of pathogenic bacteria in aquaculture: Present status and future prospects
S. F. Gonzalez, Y. Santos
Agrobios
in Fisheries, aquaculture and biotechnology (2009) pp9
Complement and natural antibody are required in the long-term memory response to influenza virus
S. Fernandez Gonzalez, J. P. Jayasekera, M. C. Carroll
in Vaccine (2008) vol. 26 Suppl 8 ppI86-93
Complement and natural antibody are required in the long-term memory response to influenza virus
S. Fernandez Gonzalez, J. P. Jayasekera, M. C. Carroll
in Vaccine (2008) vol. 26 Suppl 8 ppI86-93
Genomic resources and microarrays for the common carp Cyprinus carpio L.
D. R. Williams, W. Li, M. A. Hughes, S. F. Gonzalez, C. Vernon, M. C. Vidal, Z. Jeney, G. Jeney, P. Dixon, B. McAndrew, R. Bartfai, L. Orban, V. Trudeau, J. Rogers, L. Matthews, E. J. Fraser, A. Y. Gracey, A. R. Cossins
in J Fish Biology (2008) vol. 72 pp2095-2117
Differential transcription of multiple forms of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites
D. F. Onara, M. Forlenza, S. F. Gonzalez, K. L. Rakus, A. Pilarczyk, I. Irnazarow, G. F. Wiegertjes
in Dev Comp Immunol (2008) vol. 32 pp339-47
Complement expression in common carp (Cyprinus carpio L.) during infection with Ichthyophthirius multifiliis
S. F. Gonzalez, K. Buchmann, M. E. Nielsen
in Dev Comp Immunol (2007) vol. 31 pp576-86
Ichthyophthirius multifiliis infection induces massive up-regulation of serum amyloid A in carp (Cyprinus carpio)
S. F. Gonzalez, K. Buchmann, M. E. Nielsen
in Vet Immunol Immunopathol (2007) vol. 115 pp172-8
Cutaneous immune responses in the common carp detected using transcript analysis
S. F. Gonzalez, N. Chatziandreou, M. E. Nielsen, W. Li, J. Rogers, R. Taylor, Y. Santos, A. Cossins
in Mol Immunol (2007) vol. 44 pp1664-79
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis
S. F. Gonzalez, K. Buchmann, M. E. Nielsen
in Fish Shellfish Immunol (2007) vol. 22 pp641-50
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses to injury mimicking infection with ectoparasites
S. F. Gonzalez, M. O. Huising, R. Stakauskas, M. Forlenza, B. M. Lidy Verburg-van Kemenade, K. Buchmann, M. E. Nielsen, G. F. Wiegertjes
in Dev Comp Immunol (2007) vol. 31 pp244-54
Evaluation of the AQUARAPID-Va, AQUAEIA-Va and dot-blot assays for the detection of Vibrio anguillarum in fish tissues
S. F. Gonzalez, C. R. Osorio, Y. Santos
in J Fish Dis (2004) vol. 27 pp617-21
Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray
S. F. Gonzalez, M. J. Krug, M. E. Nielsen, Y. Santos, D. R. Call
in J Clin Microbiol (2004) vol. 42 pp1414-9
Development of a PCR-based method for the detection of Listonella anguillarum in fish tissues and blood samples
S. F. Gonzalez, C. R. Osorio, Y. Santos
in Dis Aquat Organ (2003) vol. 55 pp109-15