Santiago F. González, PhD, PhD
Infection and Immunity
Group Leader
Via Vela, 6
6500 Bellinzona,
Switzerland
- santiago.gonzalez@irb.usi.ch
- +41 91 820 0360
- +41 91 820 0305

Bio |
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Santiago F. González holds two PhD degrees, one in microbiology from the University of Santiago de Compostela (Spain) and one in immunology from the University of Copenhagen (Denmark). From January 2007 to September 2011 he was a postdoc in the group of Michael Carroll at the Immune Disease Institute, Harvard Medical School, in Boston (USA). He has been awarded three EU Marie Curie Fellowships, one for his postgraduate studies in Denmark where he studied skin inflammation and the connection between innate and adaptive responses from a molecular perspective. The second fellowship was a Marie Curie International Outgoing Fellowship awarded in 2008 for a project shared between Harvard Medical School and the National Center for Biotechnology (Madrid). The project focused on the study of the defense mechanism against Influenza virus. The third fellowship is the Marie Curie Career Integration Grant to establish his group at the IRB. He has published several papers related with antigen trafficking, memory B cell, and the regulation of the immune system in high impact journals. During his work at Harvard he studied the transport mechanism of an influenza vaccine in the lymph node. He found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. These results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination and were published in Nature Immunology. In November 2012 he joined the Institute for Research in Biomedicine in Bellinzona as a group leader studying pathogen-host interaction.
* INIMIN, a success story * Così il virus dell’influenza può essere bloccato appena entra |
Projects |
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Role of neutrophils in the immune response to virus and bacteria |
Characterization of the inflammatory reaction caused by influenza virus |
Publications |
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Early production of IL-17A by gammadelta T cells in the trachea promotes viral clearance during influenza infection in mice M. Palomino-Segura, I. Latino, Y. Farsakoglu, S. F. Gonzalez in Eur J Immunol (2019) |
Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination D. U. Pizzagalli, I. Latino, A. Pulfer, M. Palomino-Segura, T. Virgilio, Y. Farsakoglu, R. Krause, S. F. Gonzalez in Frontiers in Immunology (2019) vol. 10 |
Design of polymeric nanocapsules to improve their lympho-targeting capacity J. Crecente-Campo, T. Virgilio, D. Morone, C. Calvino-Sampedro, I. Fernandez-Marino, A. Olivera, R. Varela-Calvino, S. F. Gonzalez, M. J. Alonso in Nanomedicine (Lond) (2019) |
A trainable clustering algorithm based on shortest paths from density peaks D. U. Pizzagalli, S. F. Gonzalez, R. Krause in Science Advances (2019) vol. 5 ppeaax3770 |
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1 M. Palomino-Segura, L. Perez, Y. Farsakoglu, T. Virgilio, I. Latino, R. D'Antuono, N. Chatziandreou, D. U. Pizzagalli, G. Wang, A. Garcia-Sastre, F. Sallusto, M. C. Carroll, O. Neyrolles, S. F. Gonzalez in Nat Microbiol (2019) |
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez in Cell Rep (2019) vol. 26 pp2307-2315 e5 |
Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection M. Palomino-Segura, S. F. Gonzalez in Methods Mol Biol (2019) vol. 1968 pp183-194 |
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens M. Proietti, L. Perruzza, D. Scribano, G. Pellegrini, R. D'Antuono, F. Strati, M. Raffaelli, S. F. Gonzalez, M. Thelen, W. D. Hardt, E. Slack, M. Nicoletti, F. Grassi in Nat Commun (2019) vol. 10 pp250 |
Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system A. S. Cordeiro, J. Crecente-Campo, B. Lopez-Bouzo, S. F. Gonzalez, M. de la Fuente, M. J. Alonso in J Drug Target (2019) pp1-52 |
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity M. Bardelli, K. Frontzek, L. Simonelli, S. Hornemann, M. Pedotti, F. Mazzola, M. Carta, V. Eckhardt, R. D'Antuono, T. Virgilio, S. F. Gonzalez, A. Aguzzi, L. Varani in PLoS Pathog (2018) vol. 14 ppe1007335 |
Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy M. Palomino-Segura, T. Virgilio, D. Morone, Diego. U. Pizzagalli, S. Gonzalez F. in JoVE (2018) ppe58355 |
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos D. U. Pizzagalli, Y. Farsakoglu, M. Palomino-Segura, E. Palladino, J. Sintes, F. Marangoni, T. R. Mempel, W. H. Koh, T. T. Murooka, F. Thelen, J. V. Stein, G. Pozzi, M. Thelen, R. Krause, S. F. Gonzalez in Sci Data (2018) vol. 5 pp180129 |
Epithelial-Mesenchymal transition in cancer metastasis through the lymphatic system M. C. Karlsson, S. F. Gonzalez, J. Welin, J. Fuxe in Mol Oncol (2017) vol. 11 pp781-791 |
Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node N. Chatziandreou, Y. Farsakoglu, M. Palomino-Segura, R. D'Antuono, D. U. Pizzagalli, F. Sallusto, V. Lukacs-Kornek, M. Uguccioni, D. Corti, S. J. Turley, A. Lanzavecchia, M. C. Carroll, S. F. Gonzalez in Cell Rep (2017) vol. 18 pp2427-2440 |
Dynamic intravital imaging of cell-cell interactions in the lymph node J. V. Stein, S. F. Gonzalez in J Allergy Clin Immunol (2017) vol. 139 pp12-20 |
Development of a SYBR green I real-time PCR assay for specific identification of the fish pathogen Aeromonas salmonicida subspecies salmonicida C. Fernandez-Alvarez, S. F. Gonzalez, Y. Santos in Appl Microbiol Biotechnol (2016) vol. 100 pp10585-10595 |
Antibody-Mediated Immunity N. Baumgarth, M. C. Carroll, S. F. Gonzalez John Wiley & Sons in Textbook of Influenza, 2nd Edition (2013) |
Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation B. A. Heesters, P. Chatterjee, Y. A. Kim, S. F. Gonzalez, M. P. Kuligowski, T. Kirchhausen, M. C. Carroll in Immunity (2013) vol. 38 pp1164-75 |
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity B. F. Py, S. F. Gonzalez, K. Long, M. S. Kim, Y. A. Kim, H. Zhu, J. Yao, N. Degauque, R. Villet, P. Ymele-Leki, M. Gadjeva, G. B. Pier, M. C. Carroll, J. Yuan in Immunity (2013) vol. 38 pp1063-72 |
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2 S. E. Acton, J. L. Astarita, D. Malhotra, V. Lukacs-Kornek, B. Franz, P. R. Hess, Z. Jakus, M. Kuligowski, A. L. Fletcher, K. G. Elpek, A. Bellemare-Pelletier, L. Sceats, E. D. Reynoso, S. F. Gonzalez, D. B. Graham, J. Chang, A. Peters, M. Woodruff, Y. A. Kim, W. Swat, T. Morita, V. Kuchroo, M. C. Carroll, M. L. Kahn, K. W. Wucherpfennig, S. J. Turley in Immunity (2012) vol. 37 pp276-89 |
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks D. Malhotra, A. L. Fletcher, J. Astarita, V. Lukacs-Kornek, P. Tayalia, S. F. Gonzalez, K. G. Elpek, S. K. Chang, K. Knoblich, M. E. Hemler, M. B. Brenner, M. C. Carroll, D. J. Mooney, S. J. Turley in Nat Immunol (2012) vol. 13 pp499-510 |
Molecular cloning and expression of two beta-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after beta-glucan feeding Mv Marel, M. Adamek, S. F. Gonzalez, P. Frost, J. H. Rombout, G. F. Wiegertjes, H. F. Savelkoul, D. Steinhagen in Fish Shellfish Immunol (2012) vol. 32 pp494-501 |
Trafficking of B cell antigen in lymph nodes S. F. Gonzalez, S. E. Degn, L. A. Pitcher, M. Woodruff, B. A. Heesters, M. C. Carroll in Annu Rev Immunol (2011) vol. 29 pp215-33 |
The role of innate immunity in B cell acquisition of antigen within LNs S. F. Gonzalez, M. P. Kuligowski, L. A. Pitcher, R. Roozendaal, M. C. Carroll in Adv Immunol (2010) vol. 106 pp1-19 |
Complement-dependent transport of antigen into B cell follicles S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, L. A. Pitcher, S. E. Degn, S. J. Turley, M. C. Carroll in J Immunol (2010) vol. 185 pp2659-64 |
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, L. A. Pitcher, S. E. Degn, Y. A. Kim, M. J. Cloninger, L. Martinez-Pomares, S. Gordon, S. J. Turley, M. C. Carroll in Nat Immunol (2010) vol. 11 pp427-34 |
SIGN-R1-expressing dendritic cells are important for humoral immunity to influenza virus L. A. Pitcher, S. F. Gonzalez, V. Lukacs-Kornek, M. P. Kuligowski, Y. A. Kim, L. Martinez-Pomares, S. Gordon, S. J. Turley, M. C. Carroll in Mol Immunol (2010) vol. 47 pp2227-2227 |
The role of the complement system in trafficking of a Streptococcus vaccine in the lymph node B. A. Heesters, S. F. Gonzalez, M. C. Carroll in Mol Immunol (2010) vol. 47 pp2249-2249 |
B cell acquisition of antigen in vivo S. F. Gonzalez, L. A. Pitcher, T. Mempel, F. Schuerpf, M. C. Carroll in Curr Opin Immunol (2009) vol. 21 pp251-7 |
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles R. Roozendaal, T. R. Mempel, L. A. Pitcher, S. F. Gonzalez, A. Verschoor, R. E. Mebius, U. H. von Andrian, M. C. Carroll in Immunity (2009) vol. 30 pp264-76 |
Serological methods for the detection of pathogenic bacteria in aquaculture: Present status and future prospects S. F. Gonzalez, Y. Santos Agrobios in Fisheries, aquaculture and biotechnology (2009) pp9 |
Complement and natural antibody are required in the long-term memory response to influenza virus S. Fernandez Gonzalez, J. P. Jayasekera, M. C. Carroll in Vaccine (2008) vol. 26 Suppl 8 ppI86-93 |
Complement and natural antibody are required in the long-term memory response to influenza virus S. Fernandez Gonzalez, J. P. Jayasekera, M. C. Carroll in Vaccine (2008) vol. 26 Suppl 8 ppI86-93 |
Genomic resources and microarrays for the common carp Cyprinus carpio L. D. R. Williams, W. Li, M. A. Hughes, S. F. Gonzalez, C. Vernon, M. C. Vidal, Z. Jeney, G. Jeney, P. Dixon, B. McAndrew, R. Bartfai, L. Orban, V. Trudeau, J. Rogers, L. Matthews, E. J. Fraser, A. Y. Gracey, A. R. Cossins in J Fish Biology (2008) vol. 72 pp2095-2117 |
Differential transcription of multiple forms of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites D. F. Onara, M. Forlenza, S. F. Gonzalez, K. L. Rakus, A. Pilarczyk, I. Irnazarow, G. F. Wiegertjes in Dev Comp Immunol (2008) vol. 32 pp339-47 |
Complement expression in common carp (Cyprinus carpio L.) during infection with Ichthyophthirius multifiliis S. F. Gonzalez, K. Buchmann, M. E. Nielsen in Dev Comp Immunol (2007) vol. 31 pp576-86 |
Ichthyophthirius multifiliis infection induces massive up-regulation of serum amyloid A in carp (Cyprinus carpio) S. F. Gonzalez, K. Buchmann, M. E. Nielsen in Vet Immunol Immunopathol (2007) vol. 115 pp172-8 |
Cutaneous immune responses in the common carp detected using transcript analysis S. F. Gonzalez, N. Chatziandreou, M. E. Nielsen, W. Li, J. Rogers, R. Taylor, Y. Santos, A. Cossins in Mol Immunol (2007) vol. 44 pp1664-79 |
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis S. F. Gonzalez, K. Buchmann, M. E. Nielsen in Fish Shellfish Immunol (2007) vol. 22 pp641-50 |
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses to injury mimicking infection with ectoparasites S. F. Gonzalez, M. O. Huising, R. Stakauskas, M. Forlenza, B. M. Lidy Verburg-van Kemenade, K. Buchmann, M. E. Nielsen, G. F. Wiegertjes in Dev Comp Immunol (2007) vol. 31 pp244-54 |
Evaluation of the AQUARAPID-Va, AQUAEIA-Va and dot-blot assays for the detection of Vibrio anguillarum in fish tissues S. F. Gonzalez, C. R. Osorio, Y. Santos in J Fish Dis (2004) vol. 27 pp617-21 |
Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray S. F. Gonzalez, M. J. Krug, M. E. Nielsen, Y. Santos, D. R. Call in J Clin Microbiol (2004) vol. 42 pp1414-9 |
Development of a PCR-based method for the detection of Listonella anguillarum in fish tissues and blood samples S. F. Gonzalez, C. R. Osorio, Y. Santos in Dis Aquat Organ (2003) vol. 55 pp109-15 |