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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Roger Geiger, PhD

Systems Immunology

Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland


Roger Geiger obtained his Master’s degree in biochemistry from the ETH Zürich in 2007. During his PhD studies at the ETH Zürich with Ari Helenius, Roger studied how non-enveloped viruses penetrate the host cell membrane. In 2011, he joined the laboratory of Antonio Lanzavecchia at the IRB and received a transition postdoc fellowship from SystemsX. The focus of his research was on metabolic regulations during the T cell response. In 2016, Roger joined the research group of Matthias Mann at the Max Planck Institute of Biochemistry in Munich and received training in mass spectrometry-based proteomics. In August 2017, Roger started his own independent research group at the Institute for Research in Biomedicine to study T cell responses to tumors using systems biology techniques. 

Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin
A. Cassotta, P. Paparoditis, R. Geiger, R. R. Mettu, S. J. Landry, A. Donati, M. Benevento, M. Foglierini, D. J. M. Lewis, A. Lanzavecchia, F. Sallusto
in J Exp Med (2020) vol. 217
Dynamics in protein translation sustaining T cell preparedness
T. Wolf, W. Jin, G. Zoppi, I. A. Vogel, M. Akhmedov, C. K. E. Bleck, T. Beltraminelli, J. C. Rieckmann, N. J. Ramirez, M. Benevento, S. Notarbartolo, D. Bumann, F. Meissner, B. Grimbacher, M. Mann, A. Lanzavecchia, F. Sallusto, I. Kwee, R. Geiger
in Nat Immunol (2020)
The internal region of CtIP negatively regulates DNA end resection
S. M. Howard, I. Ceppi, R. Anand, R. Geiger, P. Cejka
in Nucleic Acids Res (2020)
A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
A. Cassotta, V. Mikol, T. Bertrand, S. Pouzieux, J. Le Parc, P. Ferrari, J. Dumas, M. Auer, F. Deisenhammer, M. Gastaldi, D. Franciotta, C. Silacci-Fregni, B. Fernandez Rodriguez, I. Giacchetto-Sasselli, M. Foglierini, D. Jarrossay, R. Geiger, F. Sallusto, A. Lanzavecchia, L. Piccoli
in Nat Med (2019) vol. 25 pp1402-1407
Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)
D. Schubert, M. C. Klein, S. Hassdenteufel, A. Caballero-Oteyza, L. Yang, M. Proietti, A. Bulashevska, J. Kemming, J. Kuhn, S. Winzer, S. Rusch, M. Fliegauf, A. A. Schaffer, S. Pfeffer, R. Geiger, A. Cavalie, H. Cao, F. Yang, Y. Li, M. Rizzi, H. Eibel, R. Kobbe, A. L. Marks, B. P. Peppers, R. W. Hostoffer, J. M. Puck, R. Zimmermann, B. Grimbacher
in J Allergy Clin Immunol (2017) vol. 141 pp1427-1438
Social network architecture of human immune cells unveiled by quantitative proteomics
J. C. Rieckmann, R. Geiger, D. Hornburg, T. Wolf, K. Kveler, D. Jarrossay, F. Sallusto, S. S. Shen-Orr, A. Lanzavecchia, M. Mann, F. Meissner
in Nat Immunol (2017) vol. 18 pp583-593
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
R. Geiger, J. C. Rieckmann, T. Wolf, C. Basso, Y. Feng, T. Fuhrer, M. Kogadeeva, P. Picotti, F. Meissner, M. Mann, N. Zamboni, F. Sallusto, A. Lanzavecchia
in Cell (2016) vol. 167 pp829-842 e13
Geiger R. and Lanzavecchia A are co-corresponding authors.
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
A. Kabanova, J. Marcandalli, T. Zhou, S. Bianchi, U. Baxa, Y. Tsybovsky, D. Lilleri, C. Silacci-Fregni, M. Foglierini, B. M. Fernandez-Rodriguez, A. Druz, B. Zhang, R. Geiger, M. Pagani, F. Sallusto, P. D. Kwong, D. Corti, A. Lanzavecchia, L. Perez
in Nat Microbiol (2016) vol. 1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
J. Tan, K. Pieper, L. Piccoli, A. Abdi, M. Foglierini, R. Geiger, C. M. Tully, D. Jarrossay, F. M. Ndungu, J. Wambua, P. Bejon, C. S. Fregni, B. Fernandez-Rodriguez, S. Barbieri, S. Bianchi, K. Marsh, V. Thathy, D. Corti, F. Sallusto, P. Bull, A. Lanzavecchia
in Nature (2016) vol. 529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.
Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap
R. Geiger, S. Luisoni, K. Johnsson, U. F. Greber, A. Helenius
in Traffic (2013) vol. 14 pp36-46
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol
R. Geiger, D. Andritschke, S. Friebe, F. Herzog, S. Luisoni, T. Heger, A. Helenius
in Nat Cell Biol (2011) vol. 13 pp1305-14