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FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
Gonzalez-Loyola, A. Bovay, E. Kim, J. Lozano, T. W. Sabine, A. Renevey, F. Arroz-Madeira, S. Rapin, A. Wypych, T. P. Rota, G. Durot, S. Velin, D. Marsland, B. Guarda, G. Delorenzi, M. Zamboni, N. Luther, S. A. Petrova, T. V.
in Sci Adv (2021) Vol.7 ppeabf4335
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
Xu, K. Wang, Y. Shen, C. H. Chen, Y. Zhang, B. Liu, K. Tsybovsky, Y. Wang, S. Farney, S. K. Gorman, J. Stephens, T. Verardi, R. Yang, Y. Zhou, T. Chuang, G. Y. Lanzavecchia, A. Piccoli, L. Kwong, P. D.
in Nat Commun (2021) Vol.12 pp4226
The P2X7 Receptor in Tumor Immunity
Grassi, F. De Ponte Conti, B.
in Front Cell Dev Biol (2021) Vol.9 pp694831
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
Greaney, A. J. Starr, T. N. Barnes, C. O. Weisblum, Y. Schmidt, F. Caskey, M. Gaebler, C. Cho, A. Agudelo, M. Finkin, S. Wang, Z. Poston, D. Muecksch, F. Hatziioannou, T. Bieniasz, P. D. Robbiani, D. F. Nussenzweig, M. C. Bjorkman, P. J. Bloom, J. D.
in Nat Commun (2021) Vol.12 pp4196
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer
Zoma, M. Curti, L. Shinde, D. Albino, D. Mitra, A. Sgrignani, J. Mapelli, S. N. Sandrini, G. Civenni, G. Merulla, J. Chiorino, G. Kunderfranco, P. Cacciatore, A. Kokanovic, A. Rinaldi, A. Cavalli, A. Catapano, C. V. Carbone, G. M.
in Nat Commun (2021) Vol.12 pp4147
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency
Yang, R. Weisshaar, M. Mele, F. Benhsaien, I. Dorgham, K. Han, J. Croft, C. A. Notarbartolo, S. Rosain, J. Bastard, P. Puel, A. Fleckenstein, B. Glimcher, L. H. Di Santo, J. P. Ma, C. S. Gorochov, G. Bousfiha, A. Abel, L. Tangye, S. G. Casanova, J. L. Bustamante, J. Sallusto, F.
in J Exp Med (2021) Vol.218 ppe20202726
Inhibition of MRN activity by a telomere protein motif
Khayat, F. Cannavo, E. Alshmery, M. Foster, W. R. Chahwan, C. Maddalena, M. Smith, C. Oliver, A. W. Watson, A. T. Carr, A. M. Cejka, P. Bianchi, A.
in Nat Commun (2021) Vol.12 pp3856
N-glycan processing selects ERAD-resistant misfolded proteins for ER-to-lysosome-associated degradation
Fregno, I. Fasana, E. Solda, T. Galli, C. Molinari, M.
in EMBO J (2021) Vol. ppe107240
Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity
Garofalo, M. Piccoli, L. Romeo, M. Barzago, M. M. Ravasio, S. Foglierini, M. Matkovic, M. Sgrignani, J. De Gasparo, R. Prunotto, M. Varani, L. Diomede, L. Michielin, O. Lanzavecchia, A. Cavalli, A.
in Nature Communications (2021) Vol.12 pp3532
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis
Gronwall, C. Liljefors, L. Bang, H. Hensvold, A. H. Hansson, M. Mathsson-Alm, L. Israelsson, L. Joshua, V. Svard, A. Stalesen, R. Titcombe, P. J. Steen, J. Piccoli, L. Sherina, N. Clavel, C. Svenungsson, E. Gunnarsson, I. Saevarsdottir, S. Kastbom, A. Serre, G. Alfredsson, L. Malmstrom, V. Ronnelid, J. Catrina, A. I. Lundberg, K. Klareskog, L.
in Front Immunol (2021) Vol.12 pp627986
Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formation
Dai, J. Sanchez, A. Adam, C. Ranjha, L. Reginato, G. Chervy, P. Tellier-Lebegue, C. Andreani, J. Guerois, R. Ropars, V. Le Du, M. H. Maloisel, L. Martini, E. Legrand, P. Thureau, A. Cejka, P. Borde, V. Charbonnier, J. B.
in Proc Natl Acad Sci U S A (2021) Vol.118 ppe2022704118
HMGB1 promotes CXCL12-dependent egress of murine B cells from Peyer’s patches in homeostasis
Spagnuolo, L. Puddinu, V. Boss, N. Spinetti, T. Oberson, A. Widmer, J. Mottas, I. Hotz, C. Bianchi, M. E. Uguccioni, M. Bourquin, C.
in Eur J Immunol (2021) Vol. pp
A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants
Diard, M. Bakkeren, E. Lentsch, V. Rocker, A. Bekele, N. A. Hoces, D. Aslani, S. Arnoldini, M. Bohi, F. Schumann-Moor, K. Adamcik, J. Piccoli, L. Lanzavecchia, A. Stadtmueller, B. M. Donohue, N. van der Woude, M. W. Hockenberry, A. Viollier, P. H. Falquet, L. Wuthrich, D. Bonfiglio, F. Loverdo, C. Egli, A. Zandomeneghi, G. Mezzenga, R. Holst, O. Meier, B. H. Hardt, W. D. Slack, E.
in Nat Microbiol (2021) Vol.6 pp830-841
Endoplasmic Reticulum (ER) and ER-Phagy
Loi, M. Marazza, A. Molinari, M.
in Prog Mol Subcell Biol (2021) Vol.59 pp99-114
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2
Low, J. S. Vaqueirinho, D. Mele, F. Foglierini, M. Jerak, J. Perotti, M. Jarrossay, D. Jovic, S. Perez, L. Cacciatore, R. Terrot, T. Pellanda, A. F. Biggiogero, M. Garzoni, C. Ferrari, P. Ceschi, A. Lanzavecchia, A. Sallusto, F. Cassotta, A.
in Science (2021) Vol.372 pp1336-1341
Rational engineering of the lccbeta T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons
Chiado, A. Bosco, F. Bardelli, M. Simonelli, L. Pedotti, M. Marmo, L. Varani, L.
in Comput Struct Biotechnol J (2021) Vol.19 pp2213-2222
Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice
Sigmund, E. C. Baur, L. Schineis, P. Arasa, J. Collado-Diaz, V. Vranova, M. Stahl, R. A. K. Thelen, M. Halin, C.
in PLoS One (2021) Vol.16 ppe0249068
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
Di Pilato, M. Palomino-Segura, M. Mejias-Perez, E. Gomez, C. E. Rubio-Ponce, A. D'Antuono, R. Pizzagalli, D. U. Perez, P. Kfuri-Rubens, R. Benguria, A. Dopazo, A. Ballesteros, I. Sorzano, C. O. S. Hidalgo, A. Esteban, M. Gonzalez, S. F.
in NPJ Vaccines (2021) Vol.6 pp52
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease
Agudelo, M. Palus, M. Keeffe, J. R. Bianchini, F. Svoboda, P. Salat, J. Peace, A. Gazumyan, A. Cipolla, M. Kapoor, T. Guidetti, F. Yao, K. H. Elsterova, J. Teislerova, D. Chrdle, A. Honig, V. Oliveira, T. West, A. P. Lee, Y. E. Rice, C. M. MacDonald, M. R. Bjorkman, P. J. Ruzek, D. Robbiani, D. F. Nussenzweig, M. C.
in J Exp Med (2021) Vol.218 ppe20210236
The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length
Vernekar, D. V. Reginato, G. Adam, C. Ranjha, L. Dingli, F. Marsolier, M. C. Loew, D. Guerois, R. Llorente, B. Cejka, P. Borde, V.
in Nucleic Acids Res (2021) Vol.49 pp4522-4533
The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study
Dietmann, A. Wenz, E. van der Meer, J. Ringli, M. Warncke, J. D. Edwards, E. Schmidt, M. H. Bernasconi, C. A. Nirkko, A. Strub, M. Miano, S. Manconi, M. Acker, J. von Manitius, S. Baumann, C. R. Valko, P. O. Yilmaz, B. Brunner, A. D. Tzovara, A. Zhang, Z. Largiader, C. R. Tafti, M. Latorre, D. Sallusto, F. Khatami, R. Bassetti, C. L. A.
in J Sleep Res (2021) Vol. ppe13296
Glomerular Macrophages in Human Auto- and Allo-Immune Nephritis
Moll, S. Angeletti, A. Scapozza, L. Cavalli, A. Ghiggeri, G. M. Prunotto, M.
in Cells (2021) Vol.10 pp603
Carboxymethyl-beta-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery
Cordeiro, A. S. Farsakoglu, Y. Crecente-Campo, J. de la Fuente, M. Gonzalez, S. F. Alonso, M. J.
in Drug Deliv Transl Res (2021) Vol. pp
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies
Chen, Y. Xu, K. Piccoli, L. Foglierini, M. Tan, J. Jin, W. Gorman, J. Tsybovsky, Y. Zhang, B. Traore, B. Silacci-Fregni, C. Daubenberger, C. Crompton, P. D. Geiger, R. Sallusto, F. Kwong, P. D. Lanzavecchia, A.
in Nature (2021) Vol.592 pp639-643
Computational identification of a putative allosteric binding pocket in TMPRSS2
Sgrignani, J. and Cavalli, A.
in Front. Mol. Biosci. (2021) Vol. pp
Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners
Marsella, A., Gobbini, E., Cassani, C., Tisi, R., Cannavo, E., Reginato, G., Cejka, P., Longhese, M. P.
in Cell Rep (2021) Vol.34 pp108906
Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature
Ingelfinger, F. Krishnarajah, S. Kramer, M. Utz, S. G. Galli, E. Lutz, M. Zwicky, P. Akarca, A. U. Jurado, N. P. Ulutekin, C. Bamert, D. Widmer, C. C. Piccoli, L. Sallusto, F. Nunez, N. G. Marafioti, T. Schneiter, D. Opitz, I. Lanzavecchia, A. Jung, H. H. De Feo, D. Mundt, S. Schreiner, B. Becher, B.
in Acta Neuropathol (2021) Vol. pp
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD
Molinari, M.
in Dev Cell (2021) Vol.56 pp949-966
Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies
Greaney, A. J. Starr, T. N. Barnes, C. O. Weisblum, Y. Schmidt, F. Caskey, M. Gaebler, C. Cho, A. Agudelo, M. Finkin, S. Wang, Z. Poston, D. Muecksch, F. Hatziioannou, T. Bieniasz, P. D. Robbiani, D. F. Nussenzweig, M. C. Bjorkman, P. J. Bloom, J. D.
in bioRxiv (2021) Vol. pp
Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2
Jun Siong Low, Daniela Vaqueirinho, Federico Mele, Mathilde Foglierini, Michela Perotti, David Jarrossay, Sandra Jovic, Tatiana Terrot, Alessandra Franzetti Pellanda, Maira Biggiogero, Christian Garzoni, Paolo Ferrari, Alessandro Ceschi, Antonio Lanzavecchia, Antonino Cassotta, Federica Sallusto
in bioRxiv (2021) Vol. pp
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
Bertoglio, F. Meier, D. Langreder, N. Steinke, S. Rand, U. Simonelli, L. Heine, P. A. Ballmann, R. Schneider, K. T. Roth, K. D. R. Ruschig, M. Riese, P. Eschke, K. Kim, Y. Schackermann, D. Pedotti, M. Kuhn, P. Zock-Emmenthal, S. Wohrle, J. Kilb, N. Herz, T. Becker, M. Grasshoff, M. Wenzel, E. V. Russo, G. Kroger, A. Brunotte, L. Ludwig, S. Fuhner, V. Kramer, S. D. Dubel, S. Varani, L. Roth, G. Cicin-Sain, L. Schubert, M. Hust, M.
in Nat Com (2021) Vol. pp
Single-molecule studies illuminate the function of RAD51 paralogs
Cejka, P
in Mol Cell (2021) Vol. pp
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, DJ, Molinari, M. et al.
in Autophagy (2021) Vol.17 pp1-382
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Thomson, E. C. Rosen, L. E. Shepherd, J. G. Spreafico, R. da Silva Filipe, A. Wojcechowskyj, J. A. Davis, C. Piccoli, L. Pascall, D. J. Dillen, J. Lytras, S. Czudnochowski, N. Shah, R. Meury, M. Jesudason, N. De Marco, A. Li, K. Bassi, J. O'Toole, A. Pinto, D. Colquhoun, R. M. Culap, K. Jackson, B. Zatta, F. Rambaut, A. Jaconi, S. Sreenu, V. B. Nix, J. Zhang, I. Jarrett, R. F. Glass, W. G. Beltramello, M. Nomikou, K. Pizzuto, M. Tong, L. Cameroni, E. Croll, T. I. Johnson, N. Di Iulio, J. Wickenhagen, A. Ceschi, A. Harbison, A. M. Mair, D. Ferrari, P. Smollett, K. Sallusto, F. Carmichael, S. Garzoni, C. Nichols, J. Galli, M. Hughes, J. Riva, A. Ho, A. Schiuma, M. Semple, M. G. Openshaw, P. J. M. Fadda, E. Baillie, J. K. Chodera, J. D. Isaric C. Investigators Covid- Genomics UK Consortium Rihn, S. J. Lycett, S. J. Virgin, H. W. Telenti, A. Corti, D. Robertson, D. L. Snell, G.
in Cell (2021) Vol.184 pp1171-1187
An optimized workflow for CRISPR-Cas9 deletion of surface and intracellular factors in primary human T lymphocytes
Leoni, C. Bianchi, N. Vincenzetti, L. Monticelli, S.
in PLoS One (2021) Vol.16 ppe0247232
Distinct Antiviral Properties of Two Different Bacterial Lysates
Roth,M. Khameneh, H. J. Fang, L. Tamm, M. Rossi, G. A.
in Canadian Respiratory Journal (2021) Vol. pp8826645
Cell-intrinsic mechanisms to restrain inflammatory responses in T lymphocytes
Dzafo, E. Bianchi, N. Monticelli, S.
in Immunol Rev (2021) Vol.300 pp181-193
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
De Gasparo, R. Pedotti, M. Simonelli, L. Nickl, P. Muecksch, F. Lorenzi, J. C. C. Mazzola, F. Magrì, D. Michalcikova, T. Haviernik, J. Honig, V. Cassaniti, I. Percivalle, E. Mrazkova, B. Polakova,N. Fortova, A. Tureckova, J. Iatsiuk, V. Di Girolamo, S. Palus, P. Zudova, D. Bednar, P. Bukova, I. Bianchini, F. Mehn, D. Nencka, R. Strakova, P. Pavlis, O. Rozman, J. Gioria, S. Sammartino, J. C. Giardina, F. Gaiarsa, S. Hammarström, Q. P. Barnes, C. O. Piralla, A. Bjorkman, P. J. Baldanti, F. Calzolai, L. Nussenzweig, M. C. Bieniasz, P. D. Hatziioannou, T. Prochazka, J. Sedlacek, R. Robbiani, D. F. Ruzek, D. Varani, L.
in Nature (2021) Vol.593 pp424-428
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
Palma, C. La Rocca, C. Gigantino, V. Aquino, G. Piccaro, G. Di Silvestre, D. Brambilla, F. Rossi, R. Bonacina, F. Lepore, M. T. Audano, M. Mitro, N. Botti, G. Bruzzaniti, S. Fusco, C. Procaccini, C. De Rosa, V. Galgani, M. Alviggi, C. Puca, A. Grassi, F. Rezzonico-Jost, T. Norata, G. D. Mauri, P. Netea, M. G. de Candia, P. Matarese, G.
in Cell Metab (2021) Vol.33 pp300-318.
MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
Sharma, S. Anand, R. Zhang, X. Francia, S. Michelini, F. Galbiati, A. Williams, H. Ronato, D. A. Masson, J. Y. Rothenberg, E. Cejka, P. d'Adda di Fagagna, F.
in Cell Rep (2021) Vol.34 pp108565

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Istituto di Ricerca in Biomedicina

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