New paper from the González Lab
on Wednesday, February 27, 2019
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. This study, published in Cell Reports, determined the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN).
In this study, Farsakoglu et. al. found that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leaded to their early production of IFNγ, which in turn regulated the recruitment of IL-6+ CD11b+ dendritic cells. Finally, this study demonstrated that the interleukin-6 (IL-6)-mediated inflammation was important for the development of an effective humoral response against influenza virus in the draining LN.
At early times following influenza vaccination, NK cells are recruited to the draining lymph node were they are activated by the type I IFN produced by necrotic lymph node macrophages. In response, NK cells produce IFNγ that promotes the recruitment of IL6+ lymph node dendritic cells. Early production of IL-6 positively regulate anti-influenza B cell responses.
Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez
in Cell Rep (2019) vol. 26 pp2307-2315 e5