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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Modulation of chemokine activity in the tissue microenvironment

Research area: Chemokines in Immunity

Group leaders: Mariagrazia Uguccioni

Researchers:

Status: In progress

We have recently provided evidence that HMGB1, a damage associated molecular pattern protein (DAMP), can synergise with the CXCR4 agonist, CXCL12, promoting immune cell influx in injured tissues and enhancing immune cell responses. Cell income is blocked by glycyrrhizin, the sweet tasting compound of liquorice root, able to abolish the synergistic effect of HMGB1 on CXCL12-dependent migration, without affecting CXCL12/CXCR4 interaction. Given the fact that CXCL12 is strongly expressed in many tissues, favouring cell influx and egression, we aim to characterize in vitro and in vivo the mechanisms of action of chemokine synergy-inducing molecules on cell trafficking.

These studies might pave the way to establish novel approaches for controlling leukocyte migration and activities.