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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

MicroRNAs in the regulation of human T lymphocytes

Research area: Molecular Immunology

Group leaders: Silvia Monticelli

Researchers:

Status: In progress

Mechanisms that regulate the threshold of T cell activation, as well as the magnitude and inflammatory potential of T cell responses are likely to be crucial in autoimmunity, and may become relevant therapeutic targets. Among the factors that can modulate T cell activation and responses, it is becoming increasingly clear that dysregulation of microRNA (miRNA) expression is involved in autoimmunity, implying that a detailed knowledge of miRNA-regulated gene expression networks is critical to gain understanding of normal and disease states. Utilizing a combination of cutting-edge cellular immunology techniques, in conjunction with the extensive investigation of the network of miRNA:mRNA interactions, we will ultimately determine the importance of miRNAs in regulating T cell pathogenicity in autoimmunity.