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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Marcus Thelen, PhD

Signal Transduction

Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland

Marcus Thelen

Marcus Thelen studied biochemistry at the University of Tübingen (DE) and received his PhD from the University of Bern in 1985. As postdoc at the Theodor-Kocher-Institute in Bern, his interests focused on inflammation and chemokines. In 1989, he went to the Rockefeller University in New York, joining the group of Alan Aderem in the Laboratory of Cellular Physiology and Immunology of the Cohn/Steinman department. Biochemical aspects of cytokine- and endotoxin-mediated phagocyte priming and cytoskeleton-mediated signal transduction were the topics of his studies. In 1992, he received a career development award (START) from the Swiss National Science Foundation and returned to the Theodor-Kocher-Institute at the University of Bern. He created his own research group working on molecular mechanisms of signal transduction in leukocytes, focusing on PI 3-kinase-dependent pathways and chemokine-mediated receptor activation. He obtained the venia docendi in 1994 and received an honorary professorship in 2001 from the University of Bern. In 2000, he moved to Bellinzona and assisted in the opening of the IRB. Marcus Thelen heads since then the Laboratory of Signal Transduction.

CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4
C. Matti, G. D'Uonnolo, M. Artinger, S. Melgrati, A. Salnikov, S. Thelen, V. Purvanov, T. D. Strobel, L. Spannagel, M. Thelen, D. F. Legler
in J Leukoc Biol (2020) vol. 107 pp1137-1154
ACKR4 Recruits GRK3 Prior to beta-Arrestins but Can Scavenge Chemokines in the Absence of beta-Arrestins
C. Matti, A. Salnikov, M. Artinger, G. D'Agostino, I. Kindinger, M. Uguccioni, M. Thelen, D. F. Legler
in Front Immunol (2020) vol. 11 pp720
Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization
D. Piffaretti, F. Burgio, M. Thelen, A. Kaelin-Lang, P. Paganetti, M. Reinert, M. L. D'Angelo
in J Photochem Photobiol B (2019) vol. 201 pp111640
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
M. Proietti, L. Perruzza, D. Scribano, G. Pellegrini, R. D'Antuono, F. Strati, M. Raffaelli, S. F. Gonzalez, M. Thelen, W. D. Hardt, E. Slack, M. Nicoletti, F. Grassi
in Nat Commun (2019) vol. 10 pp250
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
T. Girbl, T. Lenn, L. Perez*, L. Rolas, A. Barkaway, A. Thiriot, C. Del Fresno, E. Lynam, E. Hub, M. Thelen, G. Graham, R. Alon, D. Sancho, U. H. von Andrian, M. B. Voisin, A. Rot, S. Nourshargh
in Immunity (2018) vol. 49 pp1062-1076.
Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis
V. Cecchinato, G. D'Agostino, L. Raeli, A. Nerviani, M. Schiraldi, G. Danelon, A. Manzo, M. Thelen, A. Ciurea, M. E. Bianchi, A. Rubartelli, C. Pitzalis, M. Uguccioni
in Front Immunol (2018) vol. 9 pp2118
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
D. U. Pizzagalli, Y. Farsakoglu, M. Palomino-Segura, E. Palladino, J. Sintes, F. Marangoni, T. R. Mempel, W. H. Koh, T. T. Murooka, F. Thelen, J. V. Stein, G. Pozzi, M. Thelen, R. Krause, S. F. Gonzalez
in Sci Data (2018) vol. 5 pp180129
Characterization of a chimeric chemokine as a specific ligand for ACKR3
R. Ameti, S. Melgrati, E. Radice, E. Cameroni, E. Hub, S. Thelen, A. Rot, M. Thelen
in J Leukoc Biol (2018) vol. 104 pp391-400
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
Y. Zohar, G. Wildbaum, R. Novak, A. L. Salzman, M. Thelen, R. Alon, Y. Barsheshet, C. L. Karp, N. Karin
in J Clin Invest (2018) vol. 128 pp1200-1201
Membrane lipid environment: Potential modulation of chemokine receptor function
M. Thelen, D. F. Legler
in Cytokine (2018) vol. 109 pp72-75
New insights in chemokine signaling
D. F. Legler, M. Thelen
in F1000Res (2018) vol. 7 pp95
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2alpha Scaffolding Function
F. Gulluni, M. Martini, M. C. De Santis, C. C. Campa, A. Ghigo, J. P. Margaria, E. Ciraolo, I. Franco, U. Ala, L. Annaratone, D. Disalvatore, G. Bertalot, G. Viale, A. Noatynska, M. Compagno, S. Sigismund, F. Montemurro, M. Thelen, F. Fan, P. Meraldi, C. Marchio, S. Pece, A. Sapino, R. Chiarle, P. P. Di Fiore, E. Hirsch
in Cancer Cell (2017) vol. 32 pp444-459 e7
The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells
C. Mazzotti, V. Gagliostro, D. Bosisio, A. Del Prete, L. Tiberio, M. Thelen, S. Sozzani
in Front Immunol (2017) vol. 8 pp1233
ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration
V. Puddinu, S. Casella, E. Radice, S. Thelen, S. Dirnhofer, F. Bertoni, M. Thelen
in Oncotarget (2017) vol. 8 pp85068-85084
CXCL12alpha/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals
S. Negro, F. Lessi, E. Duregotti, P. Aretini, M. La Ferla, S. Franceschi, M. Menicagli, E. Bergamin, E. Radice, M. Thelen, A. Megighian, M. Pirazzini, C. M. Mazzanti, M. Rigoni, C. Montecucco
in EMBO Mol Med (2017) vol. 9 pp1000-1010
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
P. J. Collins, M. L. McCully, L. Martinez-Munoz, C. Santiago, J. Wheeldon, S. Caucheteux, S. Thelen, V. Cecchinato, J. M. Laufer, V. Purvanov, Y. R. Monneau, H. Lortat-Jacob, D. F. Legler, M. Uguccioni, M. Thelen, V. Piguet, M. Mellado, B. Moser
in FASEB J (2017) vol. 31 pp3084-3097
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation
J. J. Ziarek, A. B. Kleist, N. London, B. Raveh, N. Montpas, J. Bonneterre, G. St-Onge, C. J. DiCosmo-Ponticello, C. A. Koplinski, I. Roy, B. Stephens, S. Thelen, C. T. Veldkamp, F. D. Coffman, M. C. Cohen, M. B. Dwinell, M. Thelen, F. C. Peterson, N. Heveker, B. F. Volkman
in Sci Signal (2017) vol. 10
Modulation of chemokine receptor function by cholesterol: new prospects for pharmacological intervention
D. F. Legler, C. Matti, J. M. Laufer, B. D. Jakobs, V. Purvanov, E. Uetz-von Allmen, M. Thelen
in Mol Pharmacol (2017) vol. 91 pp331-338
Chemokines: Chemistry, Biochemistry and Biological Function
D. F. Legler, M. Thelen
in Chimia (2016) vol. 70 pp856-859
Altered CXCL12 expression reveals a dual role of CXCR4 in osteosarcoma primary tumor growth and metastasis
O. Neklyudova, M. J. Arlt, P. Brennecke, M. Thelen, A. Gvozdenovic, A. Kuzmanov, B. Robl, S. M. Botter, W. Born, B. Fuchs
in J Cancer Res Clin Oncol (2016) vol. 142 pp1739-1750
Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia
T. R. Jost, C. Borga, E. Radaelli, A. Romagnani, L. Perruzza, L. Omodho, G. Cazzaniga, A. Biondi, S. Indraccolo, M. Thelen, G. Te Kronnie, F. Grassi
in J Leukoc Biol (2016) vol. 99 pp1077-87
Monitoring Scavenging Activity of Chemokine Receptors
B. Moepps, M. Thelen
in Methods Enzymol (2016) vol. 570 pp87-118
Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets
N. Karin, G. Wildbaum, M. Thelen
in J Leukoc Biol (2016) vol. 99 pp857-62
Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4
E. Palmesino, T. Apuzzo, S. Thelen, B. Mueller, H. Langen, M. Thelen
in J Leukoc Biol (2016) vol. 99 pp971-8
An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15
F. Bachelerie, G. J. Graham, M. Locati, A. Mantovani, P. M. Murphy, R. Nibbs, A. Rot, S. Sozzani, M. Thelen
in Br J Pharmacol (2015) vol. 172 pp3945-9
Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization
N. Martinez-Martin, A. Viejo-Borbolla, R. Martin, S. Blanco, J. L. Benovic, M. Thelen, A. Alcami
in Nat Commun (2015) vol. 6 pp6163
ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer's Patches to Promote Host-Microbiota Mutualism
M. Proietti, V. Cornacchione, T. Rezzonico Jost, A. Romagnani, C. E. Faliti, L. Perruzza, R. Rigoni, E. Radaelli, F. Caprioli, S. Preziuso, B. Brannetti, M. Thelen, K. D. McCoy, E. Slack, E. Traggiai, F. Grassi
in Immunity (2014) vol. 41 pp789-801
CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
P. Abe, W. Mueller, D. Schutz, F. Mackay, M. Thelen, P. Zhang, R. Stumm
in Development (2014) vol. 141 pp1857-63
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
Y. Zohar, G. Wildbaum, R. Novak, A. L. Salzman, M. Thelen, R. Alon, Y. Barsheshet, C. L. Karp, N. Karin
in J Clin Invest (2014) vol. 124 pp2009-22
New nomenclature for atypical chemokine receptors
F. Bachelerie, G. J. Graham, M. Locati, A. Mantovani, P. M. Murphy, R. Nibbs, A. Rot, S. Sozzani, M. Thelen
in Nat Immunol (2014) vol. 15 pp207-8
CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice
P. Brennecke, M. J. Arlt, C. Campanile, K. Husmann, A. Gvozdenovic, T. Apuzzo, M. Thelen, W. Born, B. Fuchs
in Clin Exp Metastasis (2014) vol. 31 pp339-49
CXCR7 influences the migration of B cells during maturation
M. L. Humpert, D. Pinto, D. Jarrossay, M. Thelen
in Eur J Immunol (2014) vol. 44 pp694-705
International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
F. Bachelerie, A. Ben-Baruch, A. M. Burkhardt, C. Combadiere, J. M. Farber, G. J. Graham, R. Horuk, A. H. Sparre-Ulrich, M. Locati, A. D. Luster, A. Mantovani, K. Matsushima, P. M. Murphy, R. Nibbs, H. Nomiyama, C. A. Power, A. E. Proudfoot, M. M. Rosenkilde, A. Rot, S. Sozzani, M. Thelen, O. Yoshie, A. Zlotnik
in Pharmacol Rev (2014) vol. 66 pp1-79
Erratum in: Pharmacol Rev. 2014 Apr;66(2):467
Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastasis of Intratibial Xenografts in SCID Mice
P. Brennecke, M. J. Arlt, R. Muff, C. Campanile, A. Gvozdenovic, K. Husmann, N. Holzwarth, E. Cameroni, F. Ehrensperger, M. Thelen, W. Born, B. Fuchs
in PLoS One (2013) vol. 8 ppe74045
Immune response: steroids drive dendritic cells
D. Jarrossay, M. Thelen
in Nat Immunol (2013) vol. 14 pp424-426
Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus
V. Biajoux, A. Bignon, C. Freitas, V. Martinez, M. Thelen, G. Lima, J. Jakez-Ocampo, D. Emilie, L. Llorente, K. Balabanian
in J Transl Med (2012) vol. 10 pp251
The biochemistry and biology of the atypical chemokine receptors
G. J. Graham, M. Locati, A. Mantovani, A. Rot, M. Thelen
in Immunol Lett (2012) vol. 145 pp30-8
Complementary methods provide evidence for the expression of CXCR7 on human B cells
M. L. Humpert, M. Tzouros, S. Thelen, A. Bignon, A. Levoye, F. Arenzana-Seisdedos, K. Balabanian, F. Bachelerie, H. Langen, M. Thelen
in Proteomics (2012) vol. 12 pp1938-48
CCR2 Acts as Scavenger for CCL2 during Monocyte Chemotaxis
S. Volpe, E. Cameroni, B. Moepps, S. Thelen, T. Apuzzo, M. Thelen
in PLoS One (2012) vol. 7 ppe37208
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
M. Schiraldi, A. Raucci, L. M. Munoz, E. Livoti, B. Celona, E. Venereau, T. Apuzzo, F. De Marchis, M. Pedotti, A. Bachi, M. Thelen, L. Varani, M. Mellado, A. Proudfoot, M. E. Bianchi, M. Uguccioni
in J Exp Med (2012) vol. 209 pp551-63
* Highlights, Nat. Rev. Immunol. 2012, 12:232
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses
A. Viejo-Borbolla, N. Martinez-Martin, H. J. Nel, P. Rueda, R. Martin, S. Blanco, F. Arenzana-Seisdedos, M. Thelen, P. G. Fallon, A. Alcami
in PLoS Pathog (2012) vol. 8 ppe1002497
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1alpha
M. A. Barber, A. Hendrickx, M. Beullens, H. Ceulemans, D. Oxley, S. Thelen, M. Thelen, M. Bollen, H. C. Welch
in Biochem J (2012) vol. 443 pp173-83
Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor
B. Boldajipour, M. Doitsidou, K. Tarbashevich, C. Laguri, S. R. Yu, J. Ries, K. Dumstrei, S. Thelen, J. Dorries, E. M. Messerschmidt, M. Thelen, P. Schwille, M. Brand, H. Lortat-Jacob, E. Raz
in Development (2011) vol. 138 pp2909-14
Polarization of migrating monocytic cells is independent of PI 3-kinase activity
S. Volpe, S. Thelen, T. Pertel, M. J. Lohse, M. Thelen
in PLoS One (2010) vol. 5 ppe10159
CXCR7 functions as a scavenger for CXCL12 and CXCL11
U. Naumann, E. Cameroni, M. Pruenster, H. Mahabaleshwar, E. Raz, H. G. Zerwes, A. Rot, M. Thelen
in PLoS One (2010) vol. 5 ppe9175
Chemokine receptor oligomerization: functional considerations
M. Thelen, L. M. Munoz, J. M. Rodriguez-Frade, M. Mellado
in Curr Opin Pharmacol (2010) vol. 10 pp38-43
How chemokines invite leukocytes to dance
M. Thelen, J. V. Stein
in Nat Immunol (2008) vol. 9 pp953-9
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
T. N. Hartmann, V. Grabovsky, R. Pasvolsky, Z. Shulman, E. C. Buss, A. Spiegel, A. Nagler, T. Lapidot, M. Thelen, R. Alon
in J Leukoc Biol (2008) vol. 84 pp1130-40
CXCR7, CXCR4 and CXCL12: an eccentric trio?
M. Thelen, S. Thelen
in J Neuroimmunol (2008) vol. 198 pp9-13
Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase
M. A. Barber, S. Donald, S. Thelen, K. E. Anderson, M. Thelen, H. C. Welch
in J Biol Chem (2007) vol. 282 pp29967-76
Bcl10 controls TCR- and FcgammaR-induced actin polymerization
D. Rueda, O. Gaide, L. Ho, E. Lewkowicz, F. Niedergang, S. Hailfinger, F. Rebeaud, M. Guzzardi, B. Conne, M. Thelen, J. Delon, U. Ferch, T. W. Mak, J. Ruland, J. Schwaller, M. Thome
in J Immunol (2007) vol. 178 pp4373-84
Differences in CXCR4-mediated signaling in B cells
E. Palmesino, B. Moepps, P. Gierschik, M. Thelen
in Immunobiology (2006) vol. 211 pp377-89
Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells
S. Infantino, B. Moepps, M. Thelen
in J Immunol (2006) vol. 176 pp2197-207
P-Rex1 regulates neutrophil function
H. C. Welch, A. M. Condliffe, L. J. Milne, G. J. Ferguson, K. Hill, L. M. Webb, K. Okkenhaug, W. J. Coadwell, S. R. Andrews, M. Thelen, G. E. Jones, P. T. Hawkins, L. R. Stephens
in Curr Biol (2005) vol. 15 pp1867-73
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
K. Balabanian, B. Lagane, S. Infantino, K. Y. Chow, J. Harriague, B. Moepps, F. Arenzana-Seisdedos, M. Thelen, F. Bachelerie
in J Biol Chem (2005) vol. 280 pp35760-6
Unusual chemokine receptor antagonism involving a mitogen-activated protein kinase pathway
P. Ogilvie, S. Thelen, B. Moepps, P. Gierschik, A. C. da Silva Campos, M. Baggiolini, M. Thelen
in J Immunol (2004) vol. 172 pp6715-22
Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation
S. A. Didichenko, C. M. Fragoso, M. Thelen
in J Biol Chem (2003) vol. 278 pp26055-64
Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles
S. A. Didichenko, M. Thelen
in J Biol Chem (2001) vol. 276 pp48135-42
Is dimerization of chemokine receptors functionally relevant?
M. Thelen, M. Baggiolini
in Sci STKE (2001) vol. 2001 ppPE34
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
S. M. Maira, I. Galetic, D. P. Brazil, S. Kaech, E. Ingley, M. Thelen, B. A. Hemmings
in Science (2001) vol. 294 pp374-80
Dancing to the tune of chemokines
M. Thelen
in Nat Immunol (2001) vol. 2 pp129-34
Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
M. B. Delgado, I. Clark-Lewis, P. Loetscher, H. Langen, M. Thelen, M. Baggiolini, M. Wolf
in Eur J Immunol (2001) vol. 31 pp699-707
Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells
N. Djouder, G. Schmidt, M. Frings, A. Cavalie, M. Thelen, K. Aktories
in J Immunol (2001) vol. 166 pp1627-34
Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase
S. A. Didichenko, A. W. Segal, M. Thelen
in FEBS Lett (2000) vol. 485 pp147-52
Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes
B. Tilton, L. Ho, E. Oberlin, P. Loetscher, F. Baleux, I. Clark-Lewis, M. Thelen
in J Exp Med (2000) vol. 192 pp313-24
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism
T. Laux, K. Fukami, M. Thelen, T. Golub, D. Frey, P. Caroni
in J Cell Biol (2000) vol. 149 pp1455-72
Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine
A. Amara, O. Lorthioir, A. Valenzuela, A. Magerus, M. Thelen, M. Montes, J. L. Virelizier, M. Delepierre, F. Baleux, H. Lortat-Jacob, F. Arenzana-Seisdedos
in J Biol Chem (1999) vol. 274 pp23916-25
Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene
C. M. Stover, S. Thiel, M. Thelen, N. J. Lynch, T. Vorup-Jensen, J. C. Jensenius, W. J. Schwaeble
in J Immunol (1999) vol. 162 pp3481-90
Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress
R. Meier, M. Thelen, B. A. Hemmings
in EMBO J (1998) vol. 17 pp7294-303
Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils
D. M. Sanghavi, M. Thelen, N. A. Thornberry, L. Casciola-Rosen, A. Rosen
in FEBS Lett (1998) vol. 422 pp179-84
G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils
M. Thelen, S. A. Didichenko
in Ann N Y Acad Sci (1997) vol. 832 pp368-82
G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes
B. Tilton, M. Andjelkovic, S. A. Didichenko, B. A. Hemmings, M. Thelen
in J Biol Chem (1997) vol. 272 pp28096-101
Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa
I. Ibarrola, P. J. Vossebeld, C. H. Homburg, M. Thelen, D. Roos, A. J. Verhoeven
in Biochim Biophys Acta (1997) vol. 1357 pp348-58
Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
U. Forssmann, M. Uguccioni, P. Loetscher, C. A. Dahinden, H. Langen, M. Thelen, M. Baggiolini
in J Exp Med (1997) vol. 185 pp2171-6
Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils
U. Wirthmueller, B. Dewald, M. Thelen, M. K. Schafer, C. Stover, K. Whaley, J. North, P. Eggleton, K. B. Reid, W. J. Schwaeble
in J Immunol (1997) vol. 158 pp4444-51
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
L. R. Stephens, A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A. S. Smrcka, M. Thelen, K. Cadwallader, P. Tempst, P. T. Hawkins
in Cell (1997) vol. 89 pp105-14
Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2
D. Besser, A. Bardelli, S. Didichenko, M. Thelen, P. M. Comoglio, C. Ponzetto, Y. Nagamine
in Oncogene (1997) vol. 14 pp705-11
Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase
S. A. Didichenko, B. Tilton, B. A. Hemmings, K. Ballmer-Hofer, M. Thelen
in Curr Biol (1996) vol. 6 pp1271-8
Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin
M. Uguccioni, P. Loetscher, U. Forssmann, B. Dewald, H. Li, S. H. Lima, Y. Li, B. Kreider, G. Garotta, M. Thelen, M. Baggiolini
in J Exp Med (1996) vol. 183 pp2379-84
PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes
M. Thelen, M. Uguccioni, J. Bosiger
in Biochem Biophys Res Commun (1995) vol. 217 pp1255-62
A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2)
S. A. Jones, B. Moser, M. Thelen
in FEBS Lett (1995) vol. 364 pp211-4
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes
M. Thelen, M. P. Wymann, H. Langen
in Proc Natl Acad Sci U S A (1994) vol. 91 pp4960-4
Phospholipases and protein kinases during phagocyte activation
M. Thelen, U. Wirthmueller
in Curr Opin Immunol (1994) vol. 6 pp106-12
Neutrophil signal transduction and activation of the respiratory burst
M. Thelen, B. Dewald, M. Baggiolini
in Physiol Rev (1993) vol. 73 pp797-821
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
J. H. Hartwig, M. Thelen, A. Rosen, P. A. Janmey, A. C. Nairn, A. Aderem
in Nature (1992) vol. 356 pp618-22
Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane
M. Thelen, A. Rosen, A. C. Nairn, A. Aderem
in Nature (1991) vol. 351 pp320-2
GM-1, a clone of the monoblastic phagocyte U937 that expresses a large respiratory burst capacity upon activation with interferon-gamma
G. Garotta, M. Thelen, D. Delia, M. Kamber, M. Baggiolini
in J Leukoc Biol (1991) vol. 49 pp294-301
The phagocytes and the respiratory burst
M. Baggiolini, M. Thelen
H. Sies, Editors
in Oxidative Stress II (1991) pp399-420
Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia
A. Rosen, K. F. Keenan, M. Thelen, A. C. Nairn, A. Aderem
in J Exp Med (1990) vol. 172 pp1211-5
Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate
M. Thelen, A. Rosen, A. C. Nairn, A. Aderem
in Proc Natl Acad Sci U S A (1990) vol. 87 pp5603-7
Reconstitution of cell-free NADPH-oxidase from human monocytes and comparison with neutrophils
M. Thelen, M. Baggiolini
in Blood (1990) vol. 75 pp2223-8
Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils
B. Dewald, M. Thelen, M. P. Wymann, M. Baggiolini
in Biochem J (1989) vol. 264 pp879-84
Structure and properties of a novel neutrophil-activating factor (NAF) produced by human monocytes
A. Walz, P. Peveri, H. Aschauer, M. Thelen, P. Kernen, B. Dewald, M. Baggiolini
in Agents Actions (1989) vol. 26 pp148-50
[Properties and activation mechanism of neutrophilic leukocytes]
M. Baggiolini, D. A. Deranleau, B. Dewald, M. Thelen, V. von Tscharner, M. P. Wymann
in Arzneimittelforschung (1989) vol. 39 pp177-80
Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor
I. Lindley, H. Aschauer, J. M. Seifert, C. Lam, W. Brunowsky, E. Kownatzki, M. Thelen, P. Peveri, B. Dewald, V. von Tscharner, et al.
in Proc Natl Acad Sci U S A (1988) vol. 85 pp9199-203
Two transduction sequences are necessary for neutrophil activation by receptor agonists
B. Dewald, M. Thelen, M. Baggiolini
in J Biol Chem (1988) vol. 263 pp16179-84
Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist
M. Thelen, P. Peveri, P. Kernen, V. von Tscharner, A. Walz, M. Baggiolini
in FASEB J (1988) vol. 2 pp2702-6
Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation
M. Thelen, M. Wolf, M. Baggiolini
in J Clin Invest (1988) vol. 81 pp1889-95
Effects of PAF on neutrophils and mononuclear phagocytes
M. Baggiolini, B. Dewald, M. Thelen
in Prog Biochem Pharmacol (1988) vol. 22 pp90-105
The neutrophil leukocyte. Properties and mechanism of activation
M. Baggiolini, D. A. Deranleau, B. Dewald, M. Thelen, von Tscharner. V. et al.
N. Latruffe, Y. Gaudemer, P. Vignais, A. Azzi, Editors
in Dynamics of Membrane Proteins and Cellular Energetics (1988) pp83-97
Functional reconstitution of proton-pumping cytochrome-c oxidase in phospholipid vesicles
M. Muller, M. Thelen, P. O'Shea, A. Azzi
in Methods Enzymol (1986) vol. 126 pp78-87
New insights on the cytochrome c oxidase proton pump
M. Thelen, P. S. O'Shea, A. Azzi
in Biochem J (1985) vol. 227 pp163-7
Proton translocation by a native and subunit III-depleted cytochrome c oxidase reconstituted into phospholipid vesicles. Use of fluorescein-phosphatidylethanolamine as an intravesicular pH indicator
M. Thelen, P. S. O'Shea, G. Petrone, A. Azzi
in J Biol Chem (1985) vol. 260 pp3626-31
Molecular properties of reconstituted cytochrome c oxidase: new evidence supports vectorial proton translocation
A. Azzi, M. Muller, P. O'Shea, M. Thelen
in J Inorg Biochem (1985) vol. 23 pp341-7
Criteria for the measurement of proton translocation by reconstituted membrane proteins: cytochrome c oxidase
P. O'Shea, M. Thelen, A. Azzi
in Biochem. Soc. Trans. (1985) pp685-686
Studies on the molecular basis of H+ transfer through phospholipid membranes
P. O'Shea, M. Thelen, A. Azzi
in Biochem. Soc. Trans. (1985) pp682-683
On the logic of the application of double-inhibitor titrations for the elucidation of the mechanisms of energy coupling
P. S. O'Shea, M. Thelen
in FEBS Lett (1984) vol. 176 pp79-82
The use of fluorescein-dipalmitoylphosphatidylethanolamine for measuring pH-changes in the internal compartment of phospholipid vesicles
M. Thelen, G. Petrone, P. S. O'Shea, A. Azzi
in Biochim Biophys Acta (1984) vol. 766 pp161-8
Intra-vesicular pH-changes in cytochrome c oxidase vesicles as a result of ferrocytochrome c oxidation
M. Thelen, P. O'Shea, G. Petrone, A. Azzi
(1984) pp169-170
Drug-induced lipid peroxidation in mice--V. Ethane production and glutathione release in the isolated liver upon perfusion with acetaminophen
M. Thelen, A. Wendel
in Biochem Pharmacol (1983) vol. 32 pp1701-6
Studies on the molecular basis of H+ translocation by cytochrome c oxidase
R. P. Casey, C. Broger, M. Thelen, A. Azzi
in J Bioenerg Biomembr (1981) vol. 13 pp219-28
Dicyclohexylcarbodiimide binds specifically and covalently to cytochrome c oxidase while inhibiting its H+-translocating activity
R. P. Casey, M. Thelen, A. Azzi
in J Biol Chem (1980) vol. 255 pp3994-4000
The proton pump of cytochrome c oxidase: Inhibition by carbodiimides
A. Azzi, R. P. Casey, M. Thelen
(1980) pp21-22
Dicyclohexylcarbodiimide inhibits proton translocation by cytochrome c oxidase
R. P. Casey, M. Thelen, A. Azzi
in Biochem Biophys Res Commun (1979) vol. 87 pp1044-51
Hydrophobic interactions, proton movements and dicyclohexylcarbodiimide labeling of cytochrome c oxidase
A. Azzi, R. Bisson, R. P. Casey, H. Gutweniger, C. Montecucco, M. Thelen, et al.
C.P. Lee, G. Schatz, L. Ernster, Editors
in Membrane Bioenergetics (1979) pp13-20
The application of fluorescence spectroscopy to the study of biological membranes
R. P. Casey, M. Thelen, A. Azzi
A. Azzi, U. Brodbeck, P. Zahler, Editors
in Membrane proteins (1979) pp194-208
The modes of inhibition of proton translocation by cytochrome c oxidase
R. P. Casey, M. Thelen, A. Azzi
U. Weser, Editors
in Metalloproteins: Structure, Model Function and Clinical Chemistry (1979) pp57-61