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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Lisa Perruzza, PhD

T Cell Development

Scientist

Via Vela, 6
6500 Bellinzona, Switzerland

Projects
Purinergic P2X7 receptor in type 1 diabetes
Publications
Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7(-/-) mice
L. Perruzza, F. Strati, G. Gargari, A. M. D'Erchia, B. Fosso, G. Pesole, S. Guglielmetti, F. Grassi
in Sci Rep (2019) vol. 9 pp9315
P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus
C. E. Faliti, R. Gualtierotti, E. Rottoli, M. Gerosa, L. Perruzza, A. Romagnani, G. Pellegrini, B. De Ponte Conti, R. L. Rossi, M. Idzko, E. M. C. Mazza, S. Bicciato, E. Traggiai, P. L. Meroni, F. Grassi
in J Exp Med (2019) vol. 216 pp317-336
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
M. Proietti, L. Perruzza, D. Scribano, G. Pellegrini, R. D'Antuono, F. Strati, M. Raffaelli, S. F. Gonzalez, M. Thelen, W. D. Hardt, E. Slack, M. Nicoletti, F. Grassi
in Nat Commun (2019) vol. 10 pp250
Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
S. M. Ghiasi, M. S. Dahllof, Y. Osmai, M. Osmai, K. K. Jakobsen, A. Aivazidis, B. Tyrberg, L. Perruzza, M. C. B. Prause, D. P. Christensen, M. Fog-Tonnesen, M. Lundh, F. Grassi, L. Chatenoud, T. Mandrup-Poulsen
in Mol Cell Endocrinol (2018) vol. 478 pp106-114
Immunological phenotype of the murine Lrba knockout
L. Gamez-Diaz, J. Neumann, F. Jager, M. Proietti, F. Felber, P. Soulas-Sprauel, L. Perruzza, F. Grassi, T. Kogl, P. Aichele, M. Kilimann, B. Grimbacher, S. Jung
in Immunol Cell Biol (2017) vol. 95 pp789-802
T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
L. Perruzza, G. Gargari, M. Proietti, B. Fosso, A. M. D'Erchia, C. E. Faliti, T. Rezzonico-Jost, D. Scribano, L. Mauri, D. Colombo, G. Pellegrini, A. Moregola, C. Mooser, G. Pesole, M. Nicoletti, G. D. Norata, M. B. Geuking, K. D. McCoy, S. Guglielmetti, F. Grassi
in Cell Rep (2017) vol. 18 pp2566-2575
Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia
T. R. Jost, C. Borga, E. Radaelli, A. Romagnani, L. Perruzza, L. Omodho, G. Cazzaniga, A. Biondi, S. Indraccolo, M. Thelen, G. Te Kronnie, F. Grassi
in J Leukoc Biol (2016) vol. 99 pp1077-87
Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis
E. Gazzerro, S. Baldassari, S. Assereto, F. Fruscione, A. Pistorio, C. Panicucci, S. Volpi, L. Perruzza, C. Fiorillo, C. Minetti, E. Traggiai, F. Grassi, C. Bruno
in Am J Pathol (2015) vol. 185 pp3349-60
ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer's Patches to Promote Host-Microbiota Mutualism
M. Proietti, V. Cornacchione, T. Rezzonico Jost, A. Romagnani, C. E. Faliti, L. Perruzza, R. Rigoni, E. Radaelli, F. Caprioli, S. Preziuso, B. Brannetti, M. Thelen, K. D. McCoy, E. Slack, E. Traggiai, F. Grassi
in Immunity (2014) vol. 41 pp789-801