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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Pubblicazioni

2018

Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis
V. Cecchinato, G. D'Agostino, L. Raeli, A. Nerviani, M. Schiraldi, G. Danelon, A. Manzo, M. Thelen, A. Ciurea, M. E. Bianchi, A. Rubartelli, C. Pitzalis, M. Uguccioni
in Front Immunol (2018) vol. 9 pp2118

How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
J. Sgrignani, J. Chen, A. Alimonti, A. Cavalli
in Sci Rep (2018) vol. 8 pp14683

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
M. Bardelli, K. Frontzek, L. Simonelli, S. Hornemann, M. Pedotti, F. Mazzola, M. Carta, V. Eckhardt, R. D'Antuono, T. Virgilio, S. F. Gonzalez, A. Aguzzi, L. Varani
in PLoS Pathog (2018) vol. 14 ppe1007335

Regulatory control of DNA end resection by Sae2 phosphorylation
E. Cannavo, D. Johnson, S. N. Andres, V. M. Kissling, J. K. Reinert, V. Garcia, D. A. Erie, D. Hess, N. H. Thoma, R. I. Enchev, M. Peter, R. S. Williams, M. J. Neale, P. Cejka
in Nat Commun (2018) vol. 9 pp4016

Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity
G. D'Agostino, V. Cecchinato, M. Uguccioni
in Front Immunol (2018) vol. 9 pp2185

T cells in patients with narcolepsy target self-antigens of hypocretin neurons
D. Latorre, U. Kallweit, E. Armentani, M. Foglierini, F. Mele, A. Cassotta, S. Jovic, D. Jarrossay, J. Mathis, F. Zellini, B. Becher, A. Lanzavecchia, R. Khatami, M. Manconi, M. Tafti, C. L. Bassetti, F. Sallusto
in Nature (2018)

Influenza hemagglutinin membrane anchor
D. J. Benton, A. Nans, L. J. Calder, J. Turner, U. Neu, Y. P. Lin, E. Ketelaars, N. L. Kallewaard, D. Corti, A. Lanzavecchia, S. J. Gamblin, P. B. Rosenthal, J. J. Skehel
in Proc Natl Acad Sci U S A (2018)

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
D. Aschenbrenner, M. Foglierini, D. Jarrossay, D. Hu, H. L. Weiner, V. K. Kuchroo, A. Lanzavecchia, S. Notarbartolo, F. Sallusto
in Nat Immunol (2018)

MicroRNAs as modulators of T cell functions in cancer
S. Emming, M. Chirichella, S. Monticelli
in Cancer Letters (2018) vol. 430 pp172-178
* 50 days' free access article: https://authors.elsevier.com/a/1X6q415DNFU~JM

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
X. F. Kong, R. Martinez-Barricarte, J. Kennedy, F. Mele, T. Lazarov, E. K. Deenick, C. S. Ma, G. Breton, K. B. Lucero, D. Langlais, A. Bousfiha, C. Aytekin, J. Markle, C. Trouillet, F. Jabot-Hanin, C. S. L. Arlehamn, G. Rao, C. Picard, T. Lasseau, D. Latorre, S. Hambleton, C. Deswarte, Y. Itan, K. Abarca, D. Moraes-Vasconcelos, F. Ailal, A. Ikinciogullari, F. Dogu, I. Benhsaien, A. Sette, L. Abel, S. Boisson-Dupuis, B. Schroder, M. C. Nussenzweig, K. Liu, F. Geissmann, S. G. Tangye, P. Gros, F. Sallusto, J. Bustamante, J. L. Casanova
in Nat Immunol (2018) vol. 19 pp973-985

Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
M. Palomino-Segura, T. Virgilio, D. Morone, Diego. U. Pizzagalli, S. Gonzalez F.
in JoVE (2018) ppe58355

Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration
G. D'Agostino, A. Saporito, V. Cecchinato, Y. Silvestri, A. Borgeat, L. Anselmi, M. Uguccioni
in British Journal of Anaesthesia (2018)

Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
S. M. Ghiasi, M. S. Dahllof, Y. Osmai, M. Osmai, K. K. Jakobsen, A. Aivazidis, B. Tyrberg, L. Perruzza, M. C. B. Prause, D. P. Christensen, M. Fog-Tonnesen, M. Lundh, F. Grassi, L. Chatenoud, T. Mandrup-Poulsen
in Mol Cell Endocrinol (2018)

ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport
I. Fregno, E. Fasana, T. J. Bergmann, A. Raimondi, M. Loi, T. Solda, C. Galli, R. D'Antuono, D. Morone, A. Danieli, P. Paganetti, E. van Anken, M. Molinari
in EMBO J (2018)

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
N. Martinez-Martin, J. Marcandalli, C. S. Huang, C. P. Arthur, M. Perotti, M. Foglierini, H. Ho, A. M. Dosey, S. Shriver, J. Payandeh, A. Leitner, A. Lanzavecchia, L. Perez, C. Ciferri
in Cell (2018)
* L. Perez and C. Ciferri contributed equally; N M-M, LP and CC are co-corresponding authors

Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
M. M. Kassem, L. B. Christoffersen, A. Cavalli, K. Lindorff-Larsen
in Sci Rep (2018) vol. 8 pp11112

Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
D. U. Pizzagalli, Y. Farsakoglu, M. Palomino-Segura, E. Palladino, J. Sintes, F. Marangoni, T. R. Mempel, W. H. Koh, T. T. Murooka, F. Thelen, J. V. Stein, G. Pozzi, M. Thelen, R. Krause, S. F. Gonzalez
in Sci Data (2018) vol. 5 pp180129

Three branches to rule them all? UPR signaling in response to chemically- versus misfolded proteins-induced ER stress
T. J. Bergmann, M. Molinari
in Biol Cell (2018)

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
W. Castro, S. T. Chelbi, C. Niogret, C. Ramon-Barros, S. P. M. Welten, K. Osterheld, H. Wang, G. Rota, L. Morgado, E. Vivier, M. E. Raeber, O. Boyman, M. Delorenzi, D. Barras, P. C. Ho, A. Oxenius, G. Guarda
in Nat Immunol (2018)

The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides
C. Guerra, G. Brambilla Pisoni, T. Solda, M. Molinari
in Biochem Biophys Res Commun (2018) pp938 - 943

Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis
E. Armas-Gonzalez, M. J. Dominguez-Luis, A. Diaz-Martin, M. Arce-Franco, J. Castro-Hernandez, G. Danelon, V. Hernandez-Hernandez, S. Bustabad-Reyes, A. Cantabrana, M. Uguccioni, F. Diaz-Gonzalez
in Arthritis Res Ther (2018) vol. 20 pp114

Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development
J Sgrignani, M Garofalo, M Matkovic, J Merulla, C. V. Catapano, A. Cavalli
in Int. J. Mol. Sci. (2018) vol. 19 pp1591

Eat it right: ER-phagy and recovER-phagy
M. Loi, I. Fregno, C. Guerra, M. Molinari
in Biochem Soc Trans (2018) pp699–706

Human cytomegalovirus (HCMV)-specific T-cell but not neutralizing or ELISA IgG antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients
D. Lilleri, P. Zelini, C. Fornara, F. Zavaglio, T. Rampino, L. Perez, E. Gabanti, G. Gerna
in J Med Virol (2018)

Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
L. Simonelli, M. Pedotti, M. Bardelli, S. Jurt, O. Zerbe, L. Varani
in Methods Mol Biol (2018) vol. 1785 pp29-51

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone
J. E. Pickett, J. M. Thompson, A. Sadowska, C. Tkaczyk, B. R. Sellman, A. Minola, D. Corti, A. Lanzavecchia, L. S. Miller, D. L. Thorek
in Bone Res (2018) vol. 6 pp13

False human cytomegalovirus IgG-positivity at prenatal screening
M. Furione, A. Sarasini, A. Arossa, C. Fornara, D. Lilleri, L. Perez, M. Parea, M. Zavattoni, A. Spinillo, P. Marone, F. Baldanti
in J Clin Virol (2018) vol. 104 pp34-38

Insight on the regulation of chemokine activities
V. Cecchinato, M. Uguccioni
in J Leukoc Biol (2018)

Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance
I. Fregno, M. Molinari
in F1000Res (2018) vol. 7 pp454

Modulation of innate and adaptive immunity by P2X ion channels
F. Di Virgilio, A. C. Sarti, F. Grassi
in Curr Opin Immunol (2018) vol. 52 pp51-59

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
G. Rota, C. Niogret, A. T. Dang, C. R. Barros, N. P. Fonta, F. Alfei, L. Morgado, D. Zehn, W. Birchmeier, E. Vivier, G. Guarda
in Cell Rep (2018) vol. 23 pp39-49

Characterization of a chimeric chemokine as a specific ligand for ACKR3
R. Ameti, S. Melgrati, E. Radice, E. Cameroni, E. Hub, S. Thelen, A. Rot, M. Thelen
in J Leukoc Biol (2018)

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
J. Tan, B. K. Sack, D. Oyen, I. Zenklusen, L. Piccoli, S. Barbieri, M. Foglierini, C. S. Fregni, J. Marcandalli, S. Jongo, S. Abdulla, L. Perez, G. Corradin, L. Varani, F. Sallusto, B. K. L. Sim, S. L. Hoffman, S. H. I. Kappe, C. Daubenberger, I. A. Wilson, A. Lanzavecchia
in Nat Med (2018) vol. 24 pp401-407

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
I. M. Yasinska, G. Ceccone, I. Ojea-Jimenez, J. Ponti, R. Hussain, G. Siligardi, S. M. Berger, E. Fasler-Kan, M. Bardelli, L. Varani, W. Fiedler, J. Wellbrock, U. Raap, B. F. Gibbs, L. Calzolai, V. V. Sumbayev
in Nanoscale (2018) vol. 10 pp5827-5833

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection
K. A. Lloyd, J. Steen, K. Amara, P. J. Titcombe, L. Israelsson, S. L. Lundstrom, D. Zhou, R. A. Zubarev, E. Reed, L. Piccoli, C. Gabay, A. Lanzavecchia, D. Baeten, K. Lundberg, D. L. Mueller, L. Klareskog, V. Malmstrom, C. Gronwall
in Eur J Immunol (2018)

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
Y. Zohar, G. Wildbaum, R. Novak, A. L. Salzman, M. Thelen, R. Alon, Y. Barsheshet, C. L. Karp, N. Karin
in J Clin Invest (2018) vol. 128 pp1200-1201

High mobility group box 1 (HMGB1) acts as an "alarmin" to promote acute myeloid leukaemia progression
I. M. Yasinska, I. Goncalves Silva, S. S. Sakhnevych, L. Ruegg, R. Hussain, G. Siligardi, W. Fiedler, J. Wellbrock, M. Bardelli, L. Varani, U. Raap, S. Berger, B. F. Gibbs, E. Fasler-Kan, V. V. Sumbayev
in Oncoimmunology (2018) vol. 7 ppe1438109

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
T. J. Bergmann, I. Fregno, F. Fumagalli, A. Rinaldi, F. Bertoni, P. J. Boersema, P. Picotti, M. Molinari
in J Biol Chem (2018) vol. 293 pp5600-5612

Membrane lipid environment: Potential modulation of chemokine receptor function
M. Thelen, D. F. Legler
in Cytokine (2018)

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion
L. C. Lindesmith, M. L. Mallory, K. Debbink, E. F. Donaldson, P. D. Brewer-Jensen, E. W. Swann, T. P. Sheahan, R. L. Graham, M. Beltramello, D. Corti, A. Lanzavecchia, R. S. Baric
in mSphere (2018) vol. 3

A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
A. De Muyt, A. Pyatnitskaya, J. Andreani, L. Ranjha, C. Ramus, R. Laureau, A. Fernandez-Vega, D. Holoch, E. Girard, J. Govin, R. Margueron, Y. Coute, P. Cejka, R. Guerois, V. Borde
in Genes Dev (2018) vol. 32 pp283-296

Methods to Study DNA End Resection I: Recombinant Protein Purification
R. Anand, C. Pinto, P. Cejka
in Methods Enzymol (2018) vol. 600 pp25-66

Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179:1109-1118
F. Sallusto, A. Lanzavecchia
in J Immunol (2018) vol. 200 pp887-896

Dissecting human antibody responses: useful, basic and surprising findings
A. Lanzavecchia
in EMBO Mol Med (2018) ppe8879

New insights in chemokine signaling
D. F. Legler, M. Thelen
in F1000Res (2018) vol. 7 pp95

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
L. Ranjha, S. M. Howard, P. Cejka
in Chromosoma (2018)

Methods to Study DNA End Resection II: Biochemical Reconstitution Assays
C. Pinto, R. Anand, P. Cejka
in Methods Enzymol (2018) vol. 600 pp67-106

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
J. Chen, I. Guccini, D. D. Mitri, D. Brina, A. Revandkar, M. Sarti, E. Pasquini, A. Alajati, S. Pinton, M. Losa, G. Civenni, C. V. Catapano, J. Sgrignani, A. Cavalli, R. D'Antuono, J. M. Asara, A. Morandi, P. Chiarugi, S. Crotti, M. Agostini, M. Montopoli, I. Masgras, A. Rasola, R. Garcia-Escudero, N. Delaleu, A. Rinaldi, F. Bertoni, J. Bono, A. Carracedo, A. Alimonti
in Nat Genet (2018) vol. 50 pp219-228