MicroRNAs in the regulation of human T lymphocytes
Research area: Immunologia Molecolare
Group leaders: Silvia Monticelli
- Michele Chirichella, Scientist
Status: In progress
Mechanisms that regulate the threshold of T cell activation, as well as the magnitude and inflammatory potential of T cell responses are likely to be crucial in autoimmunity, and may become relevant therapeutic targets. Among the factors that can modulate T cell activation and responses, it is becoming increasingly clear that dysregulation of microRNA (miRNA) expression is involved in autoimmunity, implying that a detailed knowledge of miRNA-regulated gene expression networks is critical to gain understanding of normal and disease states. Utilizing a combination of cutting-edge cellular immunology techniques, in conjunction with the extensive investigation of the network of miRNA:mRNA interactions, we will ultimately determine the importance of miRNAs in regulating T cell pathogenicity in autoimmunity.