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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Elda Cannavò Cejka, PhD

Meccanismi di ricombinazione

Scientist

Via Vela, 6
6500 Bellinzona, Switzerland

Progetti
First steps in homologous recombination: DNA end resection
Pubblicazioni
Stepwise 5' DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble
E. Cannavo, G. Reginato, P. Cejka
in Proc Natl Acad Sci U S A (2019) vol. 116 pp5505-5513
Regulatory control of DNA end resection by Sae2 phosphorylation
E. Cannavo, D. Johnson, S. N. Andres, V. M. Kissling, J. K. Reinert, V. Garcia, D. A. Erie, D. Hess, N. H. Thoma, R. I. Enchev, M. Peter, R. S. Williams, M. J. Neale, P. Cejka
in Nat Commun (2018) vol. 9 pp4016
Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection
G. Reginato, E. Cannavo, P. Cejka
in Genes Dev (2017) vol. 31 pp2325-2330
Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
R. Anand, L. Ranjha, E. Cannavo, P. Cejka
in Mol Cell (2016) vol. 64 pp940-950
Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
J. Oh, A. Al-Zain, E. Cannavo, P. Cejka, L. S. Symington
in Mol Cell (2016) vol. 64 pp405-415
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
E. Cannavo, P. Cejka
in Nature (2014) vol. 514 pp122-5
Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection
E. Cannavo, P. Cejka, S. C. Kowalczykowski
in Proc Natl Acad Sci U S A (2013) vol. 110 ppE1661-8
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
P. Cejka, E. Cannavo, P. Polaczek, T. Masuda-Sasa, S. Pokharel, J. L. Campbell, S. C. Kowalczykowski
in Nature (2010) vol. 467 pp112-6
Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
E. Cannavo, G. Marra, J. Sabates-Bellver, M. Menigatti, S. M. Lipkin, F. Fischer, P. Cejka, J. Jiricny
in Cancer Res (2005) vol. 65 pp10759-66
Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability
P. Cejka, G. Marra, C. Hemmerle, E. Cannavo, Z. Storchova, J. Jiricny
in Cancer Res (2003) vol. 63 pp8113-7
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1
P. Cejka, L. Stojic, N. Mojas, A. M. Russell, K. Heinimann, E. Cannavo, M. di Pietro, G. Marra, J. Jiricny
in EMBO J (2003) vol. 22 pp2245-54