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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Marco Bardelli, PhD

Biologia Strutturale

Scientist

Via Vela, 6
6500 Bellinzona, Switzerland

Progetti
Investigating the role of Interleukin 3 and TIM3 for the detection and elimination of Acute Mieloid Leukemia
Pubblicazioni
Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
L. Simonelli, M. Pedotti, M. Bardelli, S. Jurt, O. Zerbe, L. Varani
in Methods Mol Biol (2018) vol. 1785 pp29-51
Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
I. M. Yasinska, G. Ceccone, I. Ojea-Jimenez, J. Ponti, R. Hussain, G. Siligardi, S. M. Berger, E. Fasler-Kan, M. Bardelli, L. Varani, W. Fiedler, J. Wellbrock, U. Raap, B. F. Gibbs, L. Calzolai, V. V. Sumbayev
in Nanoscale (2018) vol. 10 pp5827-5833
High mobility group box 1 (HMGB1) acts as an "alarmin" to promote acute myeloid leukaemia progression
I. M. Yasinska, I. Goncalves Silva, S. S. Sakhnevych, L. Ruegg, R. Hussain, G. Siligardi, W. Fiedler, J. Wellbrock, M. Bardelli, L. Varani, U. Raap, S. Berger, B. F. Gibbs, E. Fasler-Kan, V. V. Sumbayev
in Oncoimmunology (2018) vol. 7 ppe1438109
A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
J. Wang, M. Bardelli, D. A. Espinosa, M. Pedotti, T. S. Ng, S. Bianchi, L. Simonelli, E. X. Y. Lim, M. Foglierini, F. Zatta, S. Jaconi, M. Beltramello, E. Cameroni, G. Fibriansah, J. Shi, T. Barca, I. Pagani, A. Rubio, V. Broccoli, E. Vicenzi, V. Graham, S. Pullan, S. Dowall, R. Hewson, S. Jurt, O. Zerbe, K. Stettler, A. Lanzavecchia, F. Sallusto, A. Cavalli, E. Harris, S. M. Lok, L. Varani, D. Corti
in Cell (2017) vol. 171 pp229-241 e15
* J. Wang and M. Bardelli contributed equally ; S-M Lok, L.Varani and D. Corti contributed equally.
The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells
I. Goncalves Silva, I. M. Yasinska, S. S. Sakhnevych, W. Fiedler, J. Wellbrock, M. Bardelli, L. Varani, R. Hussain, G. Siligardi, G. Ceccone, S. M. Berger, Y. A. Ushkaryov, B. F. Gibbs, E. Fasler-Kan, V. V. Sumbayev
in EBioMedicine (2017) pp44-57
Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia
S. Arcangeli, M. C. Rotiroti, M. Bardelli, L. Simonelli, C. F. Magnani, A. Biondi, E. Biagi, S. Tettamanti, L. Varani
in Mol Ther (2017) vol. 25 pp1933-1945
The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells
I. Goncalves Silva, L. Ruegg, B. F. Gibbs, M. Bardelli, A. Fruehwirth, L. Varani, S. M. Berger, E. Fasler-Kan, V. V. Sumbayev
in Oncoimmunology (2016) vol. 5 ppe1195535
Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells
I. Goncalves Silva, B. F. Gibbs, M. Bardelli, L. * Varani, V. V. Sumbayev
in Oncotarget (2015) vol. 6 pp33823-33
* Co-corresponding author
Epitope mapping by solution NMR spectroscopy
M. Bardelli, E. Livoti, L. Simonelli, M. Pedotti, A. Moraes, A. P. Valente, L. Varani
in J Mol Recognit (2015) vol. 28 pp393-400
Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables
S. Arcangeli, M. Bardelli, S. Tettamanti, M. C. Rotiroti, L. Simonelli, C. F. Magnani, V. Varani, A. Biondi, E. Biagi
in 57th ASH Annual Meeting (2015) vol. 126 pp1359
The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells
A. Prokhorov, B. F. Gibbs, M. Bardelli, L. Ruegg, E. Fasler-Kan, L. * Varani, V. V. Sumbayev
in Int J Biochem Cell Biol (2014) vol. 59C pp11-20
* Co-last and co-corresponding author