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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Luca Piccoli, PhD

Regolazione del sistema immunitario


Via Vela, 6
6500 Bellinzona, Switzerland

A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
A. Cassotta, V. Mikol, T. Bertrand, S. Pouzieux, J. Le Parc, P. Ferrari, J. Dumas, M. Auer, F. Deisenhammer, M. Gastaldi, D. Franciotta, C. Silacci-Fregni, B. Fernandez Rodriguez, I. Giacchetto-Sasselli, M. Foglierini, D. Jarrossay, R. Geiger, F. Sallusto, A. Lanzavecchia, L. Piccoli
in Nat Med (2019) vol. 25 pp1402-1407
The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies
J. Tan, L. Piccoli, A. Lanzavecchia
in Annu Rev Immunol (2019) vol. 37 pp225-246
Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study
P. E. H. Jensen, C. Warnke, K. Ingenhoven, L. Piccoli, M. Gasis, C. Hermanrud, B. M. Fernandez-Rodriguez, M. Ryner, D. Kramer, J. Link, R. Ramanujam, M. Auer, D. Buck, V. Grummel, E. Bertotti, N. Fissolo, B. Oliver-Martos, P. Nytrova, M. Khalil, M. Guger, S. Rathmaier, C. Sievers-Stober, R. L. P. Lindberg, S. Hassler, D. Bachelet, O. Aktas, N. Donnellan, A. Lawton, B. Hemmer, E. K. Havrdova, B. Kieseier, H. P. Hartung, M. Comabella, X. Montalban, T. Derfuss, F. Sellebjerg, P. Donnes, M. Pallardy, S. Spindeldreher, P. Broet, F. Deisenhammer, A. Fogdell-Hahn, P. S. Sorensen, Abirisk Consortium
in J Neuroimmunol (2019) vol. 326 pp19-27
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
J. Tan, B. K. Sack, D. Oyen, I. Zenklusen, L. Piccoli, S. Barbieri, M. Foglierini, C. S. Fregni, J. Marcandalli, S. Jongo, S. Abdulla, L. Perez, G. Corradin, L. Varani, F. Sallusto, B. K. L. Sim, S. L. Hoffman, S. H. I. Kappe, C. Daubenberger, I. A. Wilson, A. Lanzavecchia
in Nat Med (2018) vol. 24 pp401-407
* Tan J., Sack B. K., Oyen D., Zenklusen I., Piccoli L. contributed equally to this work.
Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection
K. A. Lloyd, J. Steen, K. Amara, P. J. Titcombe, L. Israelsson, S. L. Lundstrom, D. Zhou, R. A. Zubarev, E. Reed, L. Piccoli, C. Gabay, A. Lanzavecchia, D. Baeten, K. Lundberg, D. L. Mueller, L. Klareskog, V. Malmstrom, C. Gronwall
in Eur J Immunol (2018) vol. 48 pp1030-1045
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities
K. Pieper, J. Tan, L. Piccoli, M. Foglierini, S. Barbieri, Y. Chen, C. Silacci-Fregni, T. Wolf, D. Jarrossay, M. Anderle, A. Abdi, F. M. Ndungu, O. K. Doumbo, B. Traore, T. M. Tran, S. Jongo, I. Zenklusen, P. D. Crompton, C. Daubenberger, P. C. Bull, F. Sallusto, A. Lanzavecchia
in Nature (2017) vol. 548 pp597-601
* Pieper K., Tan J., Piccoli, L. contributed equally to this work.
Rituximab in multiple sclerosis: Frequency and clinical relevance of anti-drug antibodies
N. Dunn, A. Juto, M. Ryner, A. Manouchehrinia, L. Piccoli, K. Fink, F. Piehl, A. Fogdell-Hahn
in Mult Scler (2017) pp1352458517720044
High-avidity IgA protects the intestine by enchaining growing bacteria
K. Moor, M. Diard, M. E. Sellin, B. Felmy, S. Y. Wotzka, A. Toska, E. Bakkeren, M. Arnoldini, F. Bansept, A. D. Co, T. Voller, A. Minola, B. Fernandez-Rodriguez, G. Agatic, S. Barbieri, L. Piccoli, C. Casiraghi, D. Corti, A. Lanzavecchia, R. R. Regoes, C. Loverdo, R. Stocker, D. R. Brumley, W. D. Hardt, E. Slack
in Nature (2017) vol. 544 pp498-502
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
J. Tan, K. Pieper, L. Piccoli, A. Abdi, M. Foglierini, R. Geiger, C. M. Tully, D. Jarrossay, F. M. Ndungu, J. Wambua, P. Bejon, C. S. Fregni, B. Fernandez-Rodriguez, S. Barbieri, S. Bianchi, K. Marsh, V. Thathy, D. Corti, F. Sallusto, P. Bull, A. Lanzavecchia
in Nature (2016) vol. 529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.
Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
L. Piccoli, I. Campo, C. S. Fregni, B. M. Rodriguez, A. Minola, F. Sallusto, M. Luisetti, D. Corti, A. Lanzavecchia
in Nat Commun (2015) vol. 6 pp7375
Rapid development of broadly influenza neutralizing antibodies through redundant mutations
L. Pappas, M. Foglierini, L. Piccoli, N. L. Kallewaard, F. Turrini, C. Silacci, B. Fernandez-Rodriguez, G. Agatic, I. Giacchetto-Sasselli, G. Pellicciotta, F. Sallusto, Q. Zhu, E. Vicenzi, D. Corti, A. Lanzavecchia
in Nature (2014) vol. 516 pp418-22
Davide Corti and Antonio Lanzavecchia equally contributed to this work.