• Visit the USI website
  • Go back to the homepage

Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Elisa Fasana, PhD

Controllo della produzione proteica

Research Assistant

Via Vela, 6
6500 Bellinzona, Switzerland

Bio

Elisa Fasana achieved her Master degree in Medical Biotechnology and Molecular Medicine in 2007 at the Institute of Neuroscience of the National Research Council (Milan, Italy). During her research project she characterized the intracellular localization of a mutant form of the vesicle-trafficking protein VAPB, P56S-VAPB, which was reported to be linked to an autosomal form of amyotrophic lateral sclerosis (ALS). She obtained her PhD degree in 2011. During her PhD thesis she investigated the transmembrane-dependent partitioning into the endoplasmic reticulum (ER) focalizing on the resident ER protein cytochrome b5. She joined the group of Maurizio Molinari at the IRB in October 2011.

Progetti
Substrate-Specific Mechanisms of Protein Degradation from the ER
Disposal of Non-Glycosylated Polypeptides from the Mammalian ER
Pubblicazioni
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport
I. Fregno, E. Fasana, T. J. Bergmann, A. Raimondi, M. Loi, T. Solda, C. Galli, R. D'Antuono, D. Morone, A. Danieli, P. Paganetti, E. van Anken, M. Molinari
in EMBO J (2018)
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
F. Fumagalli, J. Noack, T. J. Bergmann, E. C. Presmanes, G. B. Pisoni, E. Fasana, I. Fregno, C. Galli, M. Loi, T. Solda, R. D'Antuono, A. Raimondi, M. Jung, A. Melnyk, S. Schorr, A. Schreiber, L. Simonelli, L. Varani, C. Wilson-Zbinden, O. Zerbe, K. Hofmann, M. Peter, M. Quadroni, R. Zimmermann, M. Molinari
in Nat Cell Biol (2016) vol. 18 pp1173-1184
Fumagalli, F. , Noack J. and Bergmann T. contributed equally to this work. * Recommended by the Faculty of 1000
Specificity and regulation of the endoplasmic reticulum-associated degradation machinery
J. Merulla, E. Fasana, T. Solda, M. Molinari
in Traffic (2013) vol. 14 pp767-77