Human T cell response to bacteria of the Enterobacteriacae family: new paper by the Sallusto lab

A recent publication in European Journal of Immunology by the Sallusto group analyzed the human T cell response to bacteria of the Enterobacteriacae family. Enterobacteriaceae are a vast family of Gram-negative bacteria that includes harmless symbionts and potentially harmful pathogens. The latter represents a global health threat being the cause of severe deadly infections, mostly […]

Collaborating with a Nobel Prize

With the awarding of the Nobel Prize for Medicine 2020 to virologist Charles M. Rice, of Rockefeller University, USI adds another case of a direct relationship with an award winner conferred by the Royal Swedish Academy of Sciences. Davide Robbiani, Director of the Institute for Research in Biomedicine (IRB, affiliated to USI), collaborates with Prof. […]

The role of beta-arrestins in CXCL12/HMGB1-mediated signaling

The ability of chemokines to form heterocomplexes with other chemokines or HMGB1 represents an additional level of regulation for shaping their function by enhancing their potency on their cognate receptor. In recent years, the relevance of the CXCL12/HMGB1 heterocomplex activity, on the chemokine receptor CXCR4, has been widely demonstrated in models of inflammation and tissue […]

New research from Ticino on the antibody response to SARS-CoV-2

After the announcement, in May, of the first results of serological tests carried out on healthcare personnel in Ticino, significant data on the antibody response to SARS-CoV-2 is now available, thanks to the analysis carried out – among others – by the Institute for Research in Biomedicine (IRB, affiliated to USI) and Humabs BioMed (subsidiary […]

Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab

When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA molecules. This […]

Davide Robbiani takes office as new director of the IRB

The change at the helm of the Institute for Research in Biomedicine (IRB, affiliated to USI) has occurred at the end of July, with Prof. Antonio Lanzavecchia succeded by Prof. Davide Robbiani, who returns to Ticino after a brilliant career in the United States.1 The announcement was already made in June 2019, when the Foundation […]