Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab

When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA molecules. This […]

Marginal zone formation requires ACKR3 expression on B cells : a new paper by the Thelen Lab

Marginal zone formation requires ACKR3

The marginal zone (MZ) of the spleen contains a specialized set of innate-like B cells that are in direct contact with the blood. This study, published in Cell Reports, shows that expression of the atypical chemokine receptor 3 (ACKR3) defines two phenotypically, transcriptionally and functionally distinct, equal-sized populations of mouse MZ B cells (MZBs). The […]

Davide Robbiani takes office as new director of the IRB

The change at the helm of the Institute for Research in Biomedicine (IRB, affiliated to USI) has occurred at the end of July, with Prof. Antonio Lanzavecchia succeded by Prof. Davide Robbiani, who returns to Ticino after a brilliant career in the United States. The announcement was already made in June 2019, when the Foundation […]

New paper from the Grassi lab on Rejuvenating tumor-killing lymphocytes

Genetic alteration of an endogenous cell constitutes the initial trigger in tumor development. Prevention and chemotherapy have dramatically ameliorated the prognosis of many cancers. However, it has become clear that immunotherapeutic strategies can definitely contribute to the cure and possibly eradication of cancer. Within this therapeutic rationale, therapies with tumor specific chimeric antigen receptor (CAR) […]