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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Greta Guarda, PhD

Immune Mechanisms

Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland


Greta Guarda studied Molecular Biology at the University of Zurich and performed her diploma work at the Swiss Federal Institute of Technology, Zurich. From 2004 to 2007, she carried out her PhD work on T cell-mediated immunity at the Institute for Research in Biomedicine (IRB), Bellinzona. In 2007, she joined as post-doctoral fellow the University of Lausanne, where she became senior lecturer in 2010. During these years, she focused her research on NOD-like receptors and inflammasome function. She established her independent research group in 2012 thanks to the award of a Swiss National Science Foundation professorship and a European Research Council starting grant in 2013. Greta Guarda joined the IRB as Group Leader in 2018 and is Associate Professor at the Università della Svizzera italiana since 2019. For her scientific contributions, she was awarded the Premio Fondazione Dr. Ettore Balli 2018, the Pfizer Research Prize 2019, and the Friedrich Miescher Award 2020. Since 2016, she is member of the Federal Ethics Committee on Non-Human Biotechnology and in 2020 she has been elected member of the Swiss Academy of Sciences, Forum for Genetic Research.

Regulatory Factor X 7 and its Potential Link to Lymphoid Cancers
B. A. Fischer, S. T. Chelbi, G. Guarda
in Trends in Cancer (2019) vol. 6 pp6-9
SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling
C. Niogret, W. Birchmeier, G. Guarda
in Front Immunol (2019) vol. 10 pp2468
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
C. Niogret, S. M. S. Miah, G. Rota, N. P. Fonta, H. Wang, W. Held, W. Birchmeier, V. Sexl, W. Yang, E. Vivier, P. C. Ho, L. Brossay, G. Guarda
in Nat Commun (2019) vol. 10 pp1444
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
W. Castro, S. T. Chelbi, C. Niogret, C. Ramon-Barros, S. P. M. Welten, K. Osterheld, H. Wang, G. Rota, L. Morgado, E. Vivier, M. E. Raeber, O. Boyman, M. Delorenzi, D. Barras, P. C. Ho, A. Oxenius, G. Guarda
in Nat Immunol (2018) vol. 19 pp809-820
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
G. Rota, C. Niogret, A. T. Dang, C. R. Barros, N. P. Fonta, F. Alfei, L. Morgado, D. Zehn, W. Birchmeier, E. Vivier, G. Guarda
in Cell Rep (2018) vol. 23 pp39-49
The regulatory network behind MHC class I expression
M. L. M. Jongsma, G. Guarda, R. M. Spaapen
in Mol Immunol (2017)
OM-85 is an immunomodulator of interferon-beta production and inflammasome activity
A. T. Dang, C. Pasquali, K. Ludigs, G. Guarda
in Sci Rep (2017) vol. 7 pp43844
Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5
S. T. Chelbi, A. T. Dang, G. Guarda
in Adv Immunol (2017) vol. 133 pp89-119
* S. T. Chelbi and A. T. Dang equally contributed to this work.
NLRC5, a promising new entry in tumor immunology
S. T. Chelbi, G. Guarda
in J Immunother Cancer (2016) vol. 4 pp39
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels
G. Rota, K. Ludigs, S. Siegert, A. Tardivel, L. Morgado, W. Reith, A. De Gassart, G. Guarda
in J Immunol (2016) vol. 196 pp2939-46
NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
K. Ludigs, C. Jandus, D. T. Utzschneider, F. Staehli, S. Bessoles, A. T. Dang, G. Rota, W. Castro, D. Zehn, E. Vivier, W. Held, P. Romero, G. Guarda
in Nat Commun (2016) vol. 7 pp10554
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module
K. Ludigs, Q. Seguin-Estevez, S. Lemeille, I. Ferrero, G. Rota, S. Chelbi, C. Mattmann, H. R. MacDonald, W. Reith, G. Guarda
in PLoS Genet (2015) vol. 11 ppe1005088
* W. Reith and G. Guarda share the senior authorship and are corresponding authors.
NLRC5, at the Heart of Antigen Presentation
A. Neerincx, W. Castro, G. Guarda, T. A. Kufer
in Front Immunol (2013) vol. 4 pp397
*G. Guarda and T. Kufer are corresponding authors.
The Nlrp3 inflammasome regulates acute graft-versus-host disease
D. Jankovic, J. Ganesan, M. Bscheider, N. Stickel, F. C. Weber, G. Guarda, M. Follo, D. Pfeifer, A. Tardivel, K. Ludigs, A. Bouazzaoui, K. Kerl, J. C. Fischer, T. Haas, A. Schmitt-Graff, A. Manoharan, L. Muller, J. Finke, S. F. Martin, O. Gorka, C. Peschel, J. Ruland, M. Idzko, J. Duyster, E. Holler, L. E. French, H. Poeck, E. Contassot, R. Zeiser
in J Exp Med (2013) vol. 210 pp1899-910
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
Y. Yan, W. Jiang, T. Spinetti, A. Tardivel, R. Castillo, C. Bourquin, G. Guarda, Z. Tian, J. Tschopp, R. Zhou
in Immunity (2013) vol. 38 pp1154-63
Innate receptors for adaptive immunity
M. C. Michallet, G. Rota, K. Maslowski, G. Guarda
in Curr Opin Microbiol (2013) vol. 16 pp296-302
Innate and adaptive effects of inflammasomes on T cell responses
C. Dostert, K. Ludigs, G. Guarda
in Curr Opin Immunol (2013) vol. 25 pp359-65
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta production
L. Kolly, N. Busso, A. von Scheven-Gete, N. Bagnoud, I. Moix, D. Holzinger, G. Simon, A. Ives, G. Guarda, A. So, M. A. Morris, M. Hofer
in J Allergy Clin Immunol (2013) vol. 131 pp1635-43
Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
K. Ludigs, V. Parfenov, R. A. Du Pasquier, G. Guarda
in Cell Mol Life Sci (2012) vol. 69 pp3395-418
Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1
O. Gross, A. S. Yazdi, C. J. Thomas, M. Masin, L. X. Heinz, G. Guarda, M. Quadroni, S. K. Drexler, J. Tschopp
in Immunity (2012) vol. 36 pp388-400
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells
F. Staehli, K. Ludigs, L. X. Heinz, Q. Seguin-Estevez, I. Ferrero, M. Braun, K. Schroder, M. Rebsamen, A. Tardivel, C. Mattmann, H. R. MacDonald, P. Romero, W. Reith, G. Guarda, J. Tschopp
in J Immunol (2012) vol. 188 pp3820-8
*G. Guarda and J. Tschopp share the senior autorship, G. Guarda is the corresponding author.
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
J. E. Vince, W. W. Wong, I. Gentle, K. E. Lawlor, R. Allam, L. O'Reilly, K. Mason, O. Gross, S. Ma, G. Guarda, H. Anderton, R. Castillo, G. Hacker, J. Silke, J. Tschopp
in Immunity (2012) vol. 36 pp215-27
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8(+) T cells
A. Kupz, G. Guarda, T. Gebhardt, L. E. Sander, K. R. Short, D. A. Diavatopoulos, O. L. Wijburg, H. Cao, J. C. Waithman, W. Chen, D. Fernandez-Ruiz, P. G. Whitney, W. R. Heath, R. Curtiss, J. Tschopp, R. A. Strugnell, S. Bedoui
in Nat Immunol (2012) vol. 13 pp162-9
The inflammasome: an integrated view
O. Gross, C. J. Thomas, G. Guarda, J. Tschopp
in Immunol Rev (2011) vol. 243 pp136-51
*G. Guarda and J. Tschopp share the senior autorship and G. Guarda is the corresponding author.
Acute gout: The inflammasome.
G. Guarda, A.S. Yazdi, M.C. D'Ombrain, Drexler S.K.
in Current Rheumatology Reviews (2011) vol. 7 pp132-140
*G. Guarda and A. S. Yazdi equally contributed to this work.
NLRX1/NOD5 deficiency does not affect MAVS signalling
M. Rebsamen, J. Vazquez, A. Tardivel, G. Guarda, J. Curran, J. Tschopp
in Cell Death Differ (2011) vol. 18 pp1387
Type I interferon inhibits interleukin-1 production and inflammasome activation
G. Guarda, M. Braun, F. Staehli, A. Tardivel, C. Mattmann, I. Forster, M. Farlik, T. Decker, R. A. Du Pasquier, P. Romero, J. Tschopp
in Immunity (2011) vol. 34 pp213-23
*G. Guarda and M. Braun contributed equally to this work.
Differential expression of NLRP3 among hematopoietic cells
G. Guarda, M. Zenger, A. S. Yazdi, K. Schroder, I. Ferrero, P. Menu, A. Tardivel, C. Mattmann, J. Tschopp
in J Immunol (2011) vol. 186 pp2529-34
*G. Guarda and M. Zenger contributed equally to this work.
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta
A. S. Yazdi, G. Guarda, N. Riteau, S. K. Drexler, A. Tardivel, I. Couillin, J. Tschopp
in Proc Natl Acad Sci U S A (2010) vol. 107 pp19449-54
Regulation of inflammasome activity
G. Guarda, A. So
in Immunology (2010) vol. 130 pp329-36
Inflammatory caspases in innate immunity and inflammation
A. S. Yazdi, G. Guarda, M. C. D'Ombrain, S. K. Drexler
in J Innate Immun (2010) vol. 2 pp228-37
Malarial hemozoin is a Nalp3 inflammasome activating danger signal
C. Dostert, G. Guarda, J. F. Romero, P. Menu, O. Gross, A. Tardivel, M. L. Suva, J. C. Stehle, M. Kopf, I. Stamenkovic, G. Corradin, J. Tschopp
in PLoS One (2009) vol. 4 ppe6510
*G. Guarda and J. F. Romero contibuted equally to this work.
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
G. Guarda, C. Dostert, F. Staehli, K. Cabalzar, R. Castillo, A. Tardivel, P. Schneider, J. Tschopp
in Nature (2009) vol. 460 pp269-73
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
A. Martin-Fontecha, D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, F. Sallusto
in J Exp Med (2008) vol. 205 pp2561-74
*Alfonso Martín-Fontecha and Federica Sallusto are co-corresponding authors.
Activated Lymph Nodes Recruit Blood Borne NK Cells and Effector T Cells:Implications for Adaptive T Cell Responses
A. Martin-Fontecha, G. Guarda, A. Lanzavecchia, F. Sallusto
in Current Immunology Reviews (2008) vol. 4 pp20-27
The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
L. Lozza, L. Rivino, G. Guarda, D. Jarrossay, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia, J. Geginat
in Eur J Immunol (2008) vol. 38 pp30-9
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
G. Guarda, M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martin-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp743-52
Encoded Self-Assembling Chemical Libraries
S. Melkko, J. Sobek, G. Guarda, J. Scheuermann, C. E. Dumelin, D. Neri
in CHIMIA (2005) vol. 59 pp798-802