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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Cristina Leoni, PhD

Molecular Immunology


Via Vela, 6
6500 Bellinzona, Switzerland

DNA methylation dynamics in the functional regulation of human T lymphocytes
Epigenetic modifications in mast cells responses
A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes
S. Emming, N. Bianchi, S. Polletti, C. Balestrieri, C. Leoni, S. Montagner, M. Chirichella, N. Delaleu, G. Natoli, S. Monticelli
in Nat Immunol (2020) vol. 21 pp388-399
The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent
L. Vincenzetti, C. Leoni, M. Chirichella, I. Kwee, S. Monticelli
in Eur J Immunol (2019) vol. 49 pp611-625
Epigenetic and transcriptional control of mast cell responses
S. Monticelli, C. Leoni
in F1000Res (2017) vol. 6 pp2064
Dnmt3a restrains mast cell inflammatory responses
C. Leoni, S. Montagner, A. Rinaldi, F. Bertoni, S. Polletti, C. Balestrieri, S. Monticelli
in Proc Natl Acad Sci U S A (2017) vol. 114 ppE1490-E1499
Commented in Science (PMID: 28232567 )
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
S. Montagner, C. Leoni, S. Emming, G. Della Chiara, C. Balestrieri, I. Barozzi, V. Piccolo, S. Togher, M. Ko, A. Rao, G. Natoli, S. Monticelli
in Cell Rep (2016) vol. 15 pp1566-79
Epigenetics of T lymphocytes in health and disease
C. Leoni, L. Vincenzetti, S. Emming, S. Monticelli
in Swiss Med Wkly (2015) vol. 145 ppw14191
Full Text
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
F. Mele, C. Basso, C. Leoni, D. Aschenbrenner, S. Becattini, D. Latorre, A. Lanzavecchia, F. Sallusto, S. Monticelli
in Nat Commun (2015) vol. 6 pp6431
Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis
C. Leoni, S. Montagner, L. Deho, R. D'Antuono, G. De Matteis, A. V. Marzano, S. Merante, E. M. Orlandi, R. Zanotti, S. Monticelli
in Eur J Haematol (2015) vol. 95 pp566-75
Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities
L. Deho, C. Leoni, T. M. Brodie, S. Montagner, M. De Simone, S. Polletti, I. Barozzi, G. Natoli, S. Monticelli
in J Immunol (2014) vol. 193 pp2196-206