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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch



Tackling influenza with broadly neutralizing antibodies
D. Corti, E. Cameroni, B. Guarino, N. L. Kallewaard, Q. Zhu, A. Lanzavecchia
in Curr Opin Virol (2017) vol. 24 pp60-69

Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor
S. Chan, A. Frasch, C. S. Mandava, J. H. Ch'ng, M. D. P. Quintana, M. Vesterlund, M. Ghorbal, N. Joannin, O. Franzen, J. J. Lopez-Rubio, S. Barbieri, A. Lanzavecchia, S. Sanyal, M. Wahlgren
in Nat Microbiol (2017) vol. 2 pp17068

Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia
S. Arcangeli, M. C. Rotiroti, M. Bardelli, L. Simonelli, C. F. Magnani, A. Biondi, E. Biagi, S. Tettamanti, L. Varani
in Mol Ther (2017)

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans
F. Sallusto, A. Cassotta, D. Hoces, M. Foglierini, A. Lanzavecchia
in Cold Spring Harb Perspect Biol (2017)

Single or Multiple Access Channels to the CYP450s Active Site? an Answer from Free Energy Simulations of the Human Aromatase Enzyme
A. Magistrato, J. Sgrignani, R. Krause, A. Cavalli
in J Phys Chem Lett (2017)

High-avidity IgA protects the intestine by enchaining growing bacteria
K. Moor, M. Diard, M. E. Sellin, B. Felmy, S. Y. Wotzka, A. Toska, E. Bakkeren, M. Arnoldini, F. Bansept, A. D. Co, T. Voller, A. Minola, B. Fernandez-Rodriguez, G. Agatic, S. Barbieri, L. Piccoli, C. Casiraghi, D. Corti, A. Lanzavecchia, R. R. Regoes, C. Loverdo, R. Stocker, D. R. Brumley, W. D. Hardt, E. Slack
in Nature (2017)

Editorial: Regulation of Inflammation, Its Resolution and Therapeutic Targeting
M. Uguccioni, M. M. Teixeira, M. Locati, A. Mantovani
in Front Immunol (2017) vol. 8 pp415

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
P. J. Collins, M. L. McCully, L. Martinez-Munoz, C. Santiago, J. Wheeldon, S. Caucheteux, S. Thelen, V. Cecchinato, J. M. Laufer, V. Purvanov, Y. R. Monneau, H. Lortat-Jacob, D. F. Legler, M. Uguccioni, M. Thelen, V. Piguet, M. Mellado, B. Moser
in FASEB J (2017)

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation
J. J. Ziarek, A. B. Kleist, N. London, B. Raveh, N. Montpas, J. Bonneterre, G. St-Onge, C. J. DiCosmo-Ponticello, C. A. Koplinski, I. Roy, B. Stephens, S. Thelen, C. T. Veldkamp, F. D. Coffman, M. C. Cohen, M. B. Dwinell, M. Thelen, F. C. Peterson, N. Heveker, B. F. Volkman
in Sci Signal (2017) vol. 10

Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
S. Tousa, M. Semitekolou, I. Morianos, A. Banos, A. I. Trochoutsou, T. M. Brodie, N. Poulos, K. Samitas, M. Kapasa, D. Konstantopoulos, G. Paraskevopoulos, M. Gaga, C. M. Hawrylowicz, F. Sallusto, G. Xanthou
in Proc Natl Acad Sci U S A (2017)

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
L. Perruzza, G. Gargari, M. Proietti, B. Fosso, A. M. D'Erchia, C. E. Faliti, T. Rezzonico-Jost, D. Scribano, L. Mauri, D. Colombo, G. Pellegrini, A. Moregola, C. Mooser, G. Pesole, M. Nicoletti, G. D. Norata, M. B. Geuking, K. D. McCoy, S. Guglielmetti, F. Grassi
in Cell Rep (2017) vol. 18 pp2566-2575

Protection of calves by a prefusion-stabilized bovine RSV F vaccine
B. Zhang, L. Chen, C. Silacci Fregni, M. Thom, J. C. Boyington, A. Druz, M. G. Joyce, E. Guzman, W. P. Kong, Y. T. Lai, G. B. E. Stewart-Jones, Y. Tsybovsky, Y. Yang, T. Zhou, U. Baxa, J. R. Mascola, D. Corti, A. Lanzavecchia, G. Taylor, P. D. Kwong
in npj Vaccines (2017) vol. 2 pp7

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node
N. Chatziandreou, Y. Farsakoglu, M. Palomino-Segura, R. D'Antuono, D. U. Pizzagalli, F. Sallusto, V. Lukacs-Kornek, M. Uguccioni, D. Corti, S. J. Turley, A. Lanzavecchia, M. C. Carroll, S. F. Gonzalez
in Cell Rep (2017) vol. 18 pp2427-2440

Social network architecture of human immune cells unveiled by quantitative proteomics
J. C. Rieckmann, R. Geiger, D. Hornburg, T. Wolf, K. Kveler, D. Jarrossay, F. Sallusto, S. S. Shen-Orr, A. Lanzavecchia, M. Mann, F. Meissner
in Nat Immunol (2017)

Dnmt3a restrains mast cell inflammatory responses
C. Leoni, S. Montagner, A. Rinaldi, F. Bertoni, S. Polletti, C. Balestrieri, S. Monticelli
in Proc Natl Acad Sci U S A (2017) vol. 114 ppE1490-E1499
Commented in Science (PMID: 28232567 )

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?
T. J. Bergmann, F. Fumagalli, M. Loi, M. Molinari
in Mol Cell Oncol (2017) vol. 4 ppe1264351

Dynamic intravital imaging of cell-cell interactions in the lymph node
J. V. Stein, S. F. Gonzalez
in J Allergy Clin Immunol (2017) vol. 139 pp12-20

Modulation of chemokine receptor function by cholesterol: new prospects for pharmacological intervention
D. F. Legler, C. Matti, J. M. Laufer, B. D. Jakobs, V. Purvanov, E. Uetz-von Allmen, M. Thelen
in Mol Pharmacol (2017) vol. 91 pp331-338

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression
J. H. Kim, M. Grosbart, R. Anand, C. Wyman, P. Cejka, J. H. Petrini
in Cell Rep (2017) vol. 18 pp496-507

Approaches to Detect microRNA Expression in T Cell Subsets and T Cell Differentiation
S. Monticelli, T. Aijo, S. Trifari
in Methods Mol Biol (2017) vol. 1514 pp153-172