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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Greta Guarda, PhD

Immune Mechanisms

Future Group Leader (starting March 2018)

Via Vela, 6
6500 Bellinzona, Switzerland

Bio

Greta Guarda studied Molecular Biology at the University of Zurich and at the Swiss Federal Institute of Technology, Zurich. She carried out her PhD work on T cell-mediated immunity under the supervision of Federica Sallusto and Antonio Lanzavecchia at the Institute for Research in Biomedicine (IRB), Bellinzona. In 2007, she joined the group of Jürg Tschopp at the University of Lausanne as a post-doctoral fellow, and focused her research on NOD-like receptors and inflammasome function. She was appointed senior lecturer at the University of Lausanne in 2010. Thanks to the award of a Swiss National Science Foundation professorship in 2012 and a European Research Council starting grant in 2013, she established her independent research group. From March 2018 onwards, her laboratory will join the IRB. Since 2016 Greta Guarda is member of the Federal Ethics Committee on Non-Human Biotechnology.

Pubblicazioni
OM-85 is an immunomodulator of interferon-beta production and inflammasome activity
A. T. Dang, C. Pasquali, K. Ludigs, G. Guarda
in Sci Rep (2017) vol. 7 pp43844
NLRC5, a promising new entry in tumor immunology
S. T. Chelbi, G. Guarda
in J Immunother Cancer (2016) vol. 4 pp39
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels
G. Rota, K. Ludigs, S. Siegert, A. Tardivel, L. Morgado, W. Reith, A. De Gassart, G. Guarda
in J Immunol (2016) vol. 196 pp2939-46
NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
K. Ludigs, C. Jandus, D. T. Utzschneider, F. Staehli, S. Bessoles, A. T. Dang, G. Rota, W. Castro, D. Zehn, E. Vivier, W. Held, P. Romero, G. Guarda
in Nat Commun (2016) vol. 7 pp10554
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module
K. Ludigs, Q. Seguin-Estevez, S. Lemeille, I. Ferrero, G. Rota, S. Chelbi, C. Mattmann, H. R. MacDonald, W. Reith, G. Guarda
in PLoS Genet (2015) vol. 11 ppe1005088
Innate and adaptive effects of inflammasomes on T cell responses
C. Dostert, K. Ludigs, G. Guarda
in Curr Opin Immunol (2013) vol. 25 pp359-65
Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
K. Ludigs, V. Parfenov, R. A. Du Pasquier, G. Guarda
in Cell Mol Life Sci (2012) vol. 69 pp3395-418
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells
F. Staehli, K. Ludigs, L. X. Heinz, Q. Seguin-Estevez, I. Ferrero, M. Braun, K. Schroder, M. Rebsamen, A. Tardivel, C. Mattmann, H. R. MacDonald, P. Romero, W. Reith, G. Guarda, J. Tschopp
in J Immunol (2012) vol. 188 pp3820-8
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
J. E. Vince, W. W. Wong, I. Gentle, K. E. Lawlor, R. Allam, L. O'Reilly, K. Mason, O. Gross, S. Ma, G. Guarda, H. Anderton, R. Castillo, G. Hacker, J. Silke, J. Tschopp
in Immunity (2012) vol. 36 pp215-27
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta
A. S. Yazdi, G. Guarda, N. Riteau, S. K. Drexler, A. Tardivel, I. Couillin, J. Tschopp
in Proc Natl Acad Sci U S A (2010) vol. 107 pp19449-54
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
A. Martin-Fontecha, D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, F. Sallusto
in J Exp Med (2008) vol. 205 pp2561-74
Alfonso Martín-Fontecha and Federica Sallusto are co-correspondign authors.
The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
L. Lozza, L. Rivino, G. Guarda, D. Jarrossay, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia, J. Geginat
in Eur J Immunol (2008) vol. 38 pp30-9
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
G. Guarda, M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martin-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp743-52