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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Mattia Pedotti, PhD

Biologia Strutturale

Research Assistant

Via Vela, 6
6500 Bellinzona, Switzerland

Progetti
RADAR: Rationally Designed Aquatic Receptors for the detection of organic pollutants
Prediction and characterization of antibody-protein interactions in Dengue virus
Characterization of antibody-protein interactions in Diphtheria Toxin
Pubblicazioni
Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
L. Simonelli, M. Pedotti, M. Bardelli, S. Jurt, O. Zerbe, L. Varani
in Methods Mol Biol (2018) vol. 1785 pp29-51
Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors
R. La Spina, V. E. V. Ferrero, V. Aiello, M. Pedotti, L. Varani, T. Lettieri, L. Calzolai, W. Haasnoot, P. Colpo
in Biosensors (Basel) (2017) vol. 8
A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
J. Wang, M. Bardelli, D. A. Espinosa, M. Pedotti, T. S. Ng, S. Bianchi, L. Simonelli, E. X. Y. Lim, M. Foglierini, F. Zatta, S. Jaconi, M. Beltramello, E. Cameroni, G. Fibriansah, J. Shi, T. Barca, I. Pagani, A. Rubio, V. Broccoli, E. Vicenzi, V. Graham, S. Pullan, S. Dowall, R. Hewson, S. Jurt, O. Zerbe, K. Stettler, A. Lanzavecchia, F. Sallusto, A. Cavalli, E. Harris, S. M. Lok, L. Varani, D. Corti
in Cell (2017) vol. 171 pp229-241 e15
* J. Wang and M. Bardelli contributed equally ; S-M Lok, L.Varani and D. Corti contributed equally.
Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, D. Corti
in Science (2016) vol. 353 pp823-6
K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
Antibody Binding Modulates Conformational Exchange in Domain III of Dengue Virus E Protein
A. H. Moraes, L. Simonelli, M. Pedotti, F. C. Almeida, L. * Varani, A. P. Valente
in J Virol (2015) vol. 90 pp1802-11
* Co-corresponding author
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
D. Corti, J. Zhao, M. Pedotti, L. Simonelli, S. Agnihothram, C. Fett, B. Fernandez-Rodriguez, M. Foglierini, G. Agatic, F. Vanzetta, R. Gopal, C. J. Langrish, N. A. Barrett, F. Sallusto, R. S. Baric, L. Varani, M. Zambon, S. Perlman, A. Lanzavecchia
in Proc Natl Acad Sci U S A (2015) vol. 112 pp10473-8
D.C. and J.Z. contributed equally to this work.
Epitope mapping by solution NMR spectroscopy
M. Bardelli, E. Livoti, L. Simonelli, M. Pedotti, A. Moraes, A. P. Valente, L. Varani
in J Mol Recognit (2015) vol. 28 pp393-400
Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities
M. Pedotti, V. E. Ferrero, T. Lettieri, P. Colpo, S. Follonier, L. Calzolai, L. Varani
in Int J Environ Res Public Health (2015) vol. 12 pp2612-21
Rational modification of estrogen receptor by combination of computational and experimental analysis
V. E. Ferrero, M. Pedotti, A. Chiadò, L. Simonelli, L. Calzolai, T. Lettieri, L. Varani
in PLoS One (2014) vol. 9 ppe102658
Receptor-based high-throughput screening and identification of estrogens in dietary supplements using bioaffinity liquid-chromatography ion mobility mass spectrometry
P. Aqai, N. G. Blesa, H. Major, M. Pedotti, L. Varani, V. E. Ferrero, W. Haasnoot, M. W. Nielen
in Anal Bioanal Chem (2013) vol. 405 pp9427-36
Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
L. Simonelli, M. Pedotti, M. Beltramello, E. Livoti, L. Calzolai, F. Sallusto, A. Lanzavecchia, L. Varani
in PLoS One (2013) vol. 8 ppe55561
Luca Simonelli, Mattia Pedotti contributed equally to this work.
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
M. Schiraldi, A. Raucci, L. M. Munoz, E. Livoti, B. Celona, E. Venereau, T. Apuzzo, F. De Marchis, M. Pedotti, A. Bachi, M. Thelen, L. Varani, M. Mellado, A. Proudfoot, M. E. Bianchi, M. Uguccioni
in J Exp Med (2012) vol. 209 pp551-63
* Highlights, Nat. Rev. Immunol. 2012, 12:232
Computational docking of antibody-antigen complexes, opportunities and pitfalls illustrated by influenza hemagglutinin
M. Pedotti, L. Simonelli, E. Livoti, L. Varani
in Int J Mol Sci (2011) vol. 12 pp226-51