Antonio Lanzavecchia, Group Leader
Sonia Barbieri, Yiwei Chen, Blanca Maria Fernandez Rodriguez, Roger Geiger, Philipp Paparoditis, Mathilde Foglierini Perez, Luca Piccoli, Kathrin Pieper, Debora Pinna, Dora Pinto, Sara Ravasio, Isabella Giacchetto - Sasselli, Chiara Silacci Fregni, Joshua Hoong Yu Tan, Tobias Wolf, Ekaterina Zhigalova
The aim of our current work is to unravel the basis of host resistance to infectious diseases to create a new generation of passive antibody therapies and novel vaccines. The human monoclonal antibodies that we isolate from memory B cells and plasma cells can be used not only as drugs for prophylaxis and treatment of infectious diseases, but also as tools to identify vaccine candidates. Besides these translational studies we address fundamental issues with regard to the cellular basis of immunological memory, the role of somatic mutations in the generation of broadly neutralizing antibodies and the relationship between infection and autoimmunity.