• Visit the USI website
  • Go back to the homepage

Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Federico Mele, PhD

Cellular Immunology

Research Assistant

Via Vela, 6
6500 Bellinzona, Switzerland

Projects
Distribution of Mycobacterium tuberculosis-specific CD4+ T cells within distinct human memory subsets
Regulation of cytokine production in human T helper cells
Publications
Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, D. Corti
in Science (2016) vol. 353 pp823-6
K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
Follicular helper T-cells and virus-specific antibody response in primary and reactivated human cytomegalovirus infections of the immunocompetent and immunocompromised transplanted patients
F. Bruno, C. Fornara, P. Zelini, M. Furione, E. Carrara, L. Scaramuzzi, I. Cane, F. Mele, F. Sallusto, D. Lilleri, G. Gerna
in J Gen Virol (2016) vol. 97 pp1928-41
IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
S. Okada, J. G. Markle, E. K. Deenick, F. Mele, D. Averbuch, M. Lagos, M. Alzahrani, S. Al-Muhsen, R. Halwani, C. S. Ma, N. Wong, C. Soudais, L. A. Henderson, H. Marzouqa, J. Shamma, M. Gonzalez, R. Martinez-Barricarte, C. Okada, D. T. Avery, D. Latorre, C. Deswarte, F. Jabot-Hanin, E. Torrado, J. Fountain, A. Belkadi, Y. Itan, B. Boisson, M. Migaud, C. S. Arlehamn, A. Sette, S. Breton, J. McCluskey, J. Rossjohn, J. P. de Villartay, D. Moshous, S. Hambleton, S. Latour, P. D. Arkwright, C. Picard, O. Lantz, D. Engelhard, M. Kobayashi, L. Abel, A. M. Cooper, L. D. Notarangelo, S. Boisson-Dupuis, A. Puel, F. Sallusto, J. Bustamante, S. G. Tangye, J. L. Casanova
in Science (2015) vol. 349 pp606-13
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
F. Mele, C. Basso, C. Leoni, D. Aschenbrenner, S. Becattini, D. Latorre, A. Lanzavecchia, F. Sallusto, S. Monticelli
in Nat Commun (2015) vol. 6 pp6431
Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
S. Becattini, D. Latorre, F. Mele, M. Foglierini, C. De Gregorio, A. Cassotta, B. Fernandez, S. Kelderman, T. N. Schumacher, D. Corti, A. Lanzavecchia, F. Sallusto
in Science (2015) vol. 347 pp400-6
Abstract
Reprint
Full Text
Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes
C. S. Lindestam Arlehamn, S. Paul, F. Mele, C. Huang, J. A. Greenbaum, R. Vita, J. Sidney, B. Peters, F. Sallusto, A. Sette
in Proc Natl Acad Sci U S A (2015) vol. 112 ppE147-55
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset
C. S. Lindestam Arlehamn, A. Gerasimova, F. Mele, R. Henderson, J. Swann, J. A. Greenbaum, Y. Kim, J. Sidney, E. A. James, R. Taplitz, D. M. McKinney, W. W. Kwok, H. Grey, F. Sallusto, B. Peters, A. Sette
in PLoS Pathog (2013) vol. 9 ppe1003130
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto
in Nature (2012) vol. 484 pp514-8
Dissecting the human immunologic memory for pathogens
C. E. Zielinski, D. Corti, F. Mele, D. Pinto, A. Lanzavecchia, F. Sallusto
in Immunol Rev (2011) vol. 240 pp40-51