• Visit the USI website
  • Go back to the homepage

Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Federica Sallusto

Cellular Immunology

Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland

Federica Sallusto
Bio

Federica Sallusto received the degree of Doctor in Biology from the University of Rome and performed postdoctoral training at the Istituto Superiore di Sanità in Rome working on T cell response to allergens and at the Basel Institute for Immunology in the laboratory of Antonio Lanzavecchia on human monocyte-derived dendritic cells. In 1997 she became member of the Basel Institute and since 2000 she is group leader at the IRB. Her studies in the human system revealed a differential expression of chemokine receptors in Th1 and Th2 cells and led to the characterization of “central memory” and “effector memory” T cells as memory subsets with distinct migratory capacity and effector function. Among her recent contributions are the discovery of Th22 cells, the identification of markers to identify human Th17 cells and the characterization of two distinct types of pathogen-specific Th17 cells that produce IFN-g or IL-10. Studies in the mouse model challenged current dogmas as to the mechanisms that control lymphocyte migration in lymph nodes and in the central nervous system; more recently her lab showed that persistent antigen and germinal centre B cells sustain Tfh cell responses and phenotype. For her scientific achievements, Federica Sallusto received the Pharmacia Allergy Research Foundation Award in 1999, the Behring Lecture Prize in 2009, and the Science Award from the Foundation for Studies of Neurodegenerative Diseases in 2010. She was elected member of the German Academy of Science Leopoldina in 2009 and member of EMBO in 2011. She is President of the Swiss Society for Allergology and Immunology for the period 2013-2015.

Projects
Distribution of allergen specific cells in human effector and memory T cell subsets
The role of B cells as antigen presenting cells in allergic inflammation
Innate and adaptive immune response to C. albicans
Pertussis toxin-driven IL-1β production is required for priming of highly encephalitogenic GM-CSF+ T cells and for EAE pathogenesis
Cervical lymph nodes and the pivotal role in the CCR6+ T helper cell priming
CXCR5+ follicular helper T cells: generation, trafficking and relationship with other T cell lineages
T follicular helper cell response in lymphopenic mice
T follicular helper cell response and phenotype are sustained by persistent antigen and germinal center B cells
Dissecting the naïve T cell repertoire – a way to define novel tumour antigens
Specificity and distribution of self-reactive T cells in health and disease
Distribution of Mycobacterium tuberculosis-specific CD4+ T cells within distinct human memory subsets
Proteome wide analysis of HIV specific naïve and memory CD4+ T cells in unexposed blood donors
Development of a multiflow panel for the analysis of chemokine receptor expression on human T helper cells
Regulation of cytokine production in human T helper cells
Unravelling the transcriptional circuit regulating IL-10 production in human Th17 cells
Deciphering the class and specificity of the T cell response to C. albicans
Pathogen-induced human Th17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
Publications
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
N. L. Kallewaard, D. Corti, P. J. Collins, U. Neu, J. M. McAuliffe, E. Benjamin, L. Wachter-Rosati, F. J. Palmer-Hill, A. Q. Yuan, P. A. Walker, M. K. Vorlaender, S. Bianchi, B. Guarino, A. De Marco, F. Vanzetta, G. Agatic, M. Foglierini, D. Pinna, B. Fernandez-Rodriguez, A. Fruehwirth, C. Silacci, R. W. Ogrodowicz, S. R. Martin, F. Sallusto, J. A. Suzich, A. Lanzavecchia, Q. Zhu, S. J. Gamblin, J. J. Skehel
in Cell (2016) vol. 166 pp596-608
Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, D. Corti
in Science (2016) vol. 353 pp823-6
K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
Host response: Mice and humans in the bubble
F. Sallusto
in Nat Microbiol (2016) vol. 1 pp16105
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
A. Kabanova, J. Marcandalli, T. Zhou, S. Bianchi, U. Baxa, Y. Tsybovsky, D. Lilleri, C. Silacci-Fregni, M. Foglierini, B. M. Fernandez-Rodriguez, A. Druz, B. Zhang, R. Geiger, M. Pagani, F. Sallusto, P. D. Kwong, D. Corti, A. Lanzavecchia, L. Perez
in Nat Microbiol (2016) vol. 1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells
F. Ronchi, C. Basso, S. Preite, A. Reboldi, D. Baumjohann, L. Perlini, A. Lanzavecchia, F. Sallusto
in Nat Commun (2016) vol. 7 pp11541
Francesca Ronchi and Camilla Basso equally contributed to this work.
Follicular helper T-cells and virus-specific antibody response in primary and reactivated human cytomegalovirus infections of the immunocompetent and immunocompromised transplanted patients
F. Bruno, C. Fornara, P. Zelini, M. Furione, E. Carrara, L. Scaramuzzi, I. Cane, F. Mele, F. Sallusto, D. Lilleri, G. Gerna
in J Gen Virol (2016) vol. 97 pp1928-41
The Human Vaccines Project: A roadmap for cancer vaccine development
P. Romero, J. Banchereau, N. Bhardwaj, M. Cockett, M. L. Disis, G. Dranoff, E. Gilboa, S. A. Hammond, R. Hershberg, A. J. Korman, P. Kvistborg, C. Melief, I. Mellman, A. K. Palucka, I. Redchenko, H. Robins, F. Sallusto, T. Schenkelberg, S. Schoenberger, J. Sosman, O. Tureci, B. Van den Eynde, W. Koff, G. Coukos
in Sci Transl Med (2016) vol. 8 pp334ps9
Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis
P. De Benedictis, A. Minola, E. Rota Nodari, R. Aiello, B. Zecchin, A. Salomoni, M. Foglierini, G. Agatic, F. Vanzetta, R. Lavenir, A. Lepelletier, E. Bentley, R. Weiss, G. Cattoli, I. Capua, F. Sallusto, E. Wright, A. Lanzavecchia, H. Bourhy, D. Corti
in EMBO Mol Med (2016) vol. 8 pp407-21
Paola De Benedictis and Andrea Minola equally contributed to this work.
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
D. Corti, J. Misasi, S. Mulangu, D. A. Stanley, M. Kanekiyo, S. Wollen, A. Ploquin, N. A. Doria-Rose, R. P. Staupe, M. Bailey, W. Shi, M. Choe, H. Marcus, E. A. Thompson, A. Cagigi, C. Silacci, B. Fernandez-Rodriguez, L. Perez, F. Sallusto, F. Vanzetta, G. Agatic, E. Cameroni, N. Kisalu, I. Gordon, J. E. Ledgerwood, J. R. Mascola, B. S. Graham, J. J. Muyembe-Tamfun, J. C. Trefry, A. Lanzavecchia, N. J. Sullivan
in Science (2016) vol. 351 pp1339-42
Davide Corti and John Misasi equally contributed to this work; John C. Trefry, Antonio Lanzavecchia, and Nancy J. Sullivan equally contributed to this work.
T-cell epitope conservation across allergen species is a major determinant of immunogenicity
L. Westernberg, V. Schulten, J. A. Greenbaum, S. Natali, V. Tripple, D. M. McKinney, A. Frazier, H. Hofer, M. Wallner, F. Sallusto, A. Sette, B. Peters
in J Allergy Clin Immunol (2016) vol. 138 pp571-578
Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma
N. Jacquelot, D. P. Enot, C. Flament, N. Vimond, C. Blattner, J. M. Pitt, T. Yamazaki, M. P. Roberti, R. Daillere, M. Vetizou, V. Poirier-Colame, M. Semeraro, A. Caignard, C. L. Slingluff, F. Sallusto, S. Rusakiewicz, B. Weide, A. Marabelle, H. Kohrt, S. Dalle, A. Cavalcanti, G. Kroemer, A. M. Di Giacomo, M. Maio, P. Wong, J. Yuan, J. Wolchok, V. Umansky, A. Eggermont, L. Zitvogel
in J Clin Invest (2016) vol. 126 pp921-37
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
J. Tan, K. Pieper, L. Piccoli, A. Abdi, M. Foglierini, R. Geiger, C. M. Tully, D. Jarrossay, F. M. Ndungu, J. Wambua, P. Bejon, C. S. Fregni, B. Fernandez-Rodriguez, S. Barbieri, S. Bianchi, K. Marsh, V. Thathy, D. Corti, F. Sallusto, P. Bull, A. Lanzavecchia
in Nature (2016) vol. 529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.
Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments
R. Campana, K. Moritz, K. Marth, A. Neubauer, H. Huber, R. Henning, K. Blatt, G. Hoermann, T. M. Brodie, A. Kaider, P. Valent, F. Sallusto, S. Wohrl, R. Valenta
in J Allergy Clin Immunol (2016) vol. 137 pp601-609 e8
Heterogeneity of Human CD4(+) T Cells Against Microbes
F. Sallusto
in Annu Rev Immunol (2016) vol. 34 pp317-34
Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis
K. Trautwein-Weidner, A. Gladiator, F. R. Kirchner, S. Becattini, T. Rulicke, F. Sallusto, S. LeibundGut-Landmann
in PLoS Pathog (2015) vol. 11 ppe1005164
Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells
S. Preite, D. Baumjohann, M. Foglierini, C. Basso, F. Ronchi, B. M. Rodriguez, D. Corti, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2015) vol. 45 pp3010-21
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
D. Corti, J. Zhao, M. Pedotti, L. Simonelli, S. Agnihothram, C. Fett, B. Fernandez-Rodriguez, M. Foglierini, G. Agatic, F. Vanzetta, R. Gopal, C. J. Langrish, N. A. Barrett, F. Sallusto, R. S. Baric, L. Varani, M. Zambon, S. Perlman, A. Lanzavecchia
in Proc Natl Acad Sci U S A (2015) vol. 112 pp10473-8
D.C. and J.Z. contributed equally to this work.
IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
S. Okada, J. G. Markle, E. K. Deenick, F. Mele, D. Averbuch, M. Lagos, M. Alzahrani, S. Al-Muhsen, R. Halwani, C. S. Ma, N. Wong, C. Soudais, L. A. Henderson, H. Marzouqa, J. Shamma, M. Gonzalez, R. Martinez-Barricarte, C. Okada, D. T. Avery, D. Latorre, C. Deswarte, F. Jabot-Hanin, E. Torrado, J. Fountain, A. Belkadi, Y. Itan, B. Boisson, M. Migaud, C. S. Arlehamn, A. Sette, S. Breton, J. McCluskey, J. Rossjohn, J. P. de Villartay, D. Moshous, S. Hambleton, S. Latour, P. D. Arkwright, C. Picard, O. Lantz, D. Engelhard, M. Kobayashi, L. Abel, A. M. Cooper, L. D. Notarangelo, S. Boisson-Dupuis, A. Puel, F. Sallusto, J. Bustamante, S. G. Tangye, J. L. Casanova
in Science (2015) vol. 349 pp606-13
Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
L. Piccoli, I. Campo, C. S. Fregni, B. M. Rodriguez, A. Minola, F. Sallusto, M. Luisetti, D. Corti, A. Lanzavecchia
in Nat Commun (2015) vol. 6 pp7375
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
F. Mele, C. Basso, C. Leoni, D. Aschenbrenner, S. Becattini, D. Latorre, A. Lanzavecchia, F. Sallusto, S. Monticelli
in Nat Commun (2015) vol. 6 pp6431
Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
S. Becattini, D. Latorre, F. Mele, M. Foglierini, C. De Gregorio, A. Cassotta, B. Fernandez, S. Kelderman, T. N. Schumacher, D. Corti, A. Lanzavecchia, F. Sallusto
in Science (2015) vol. 347 pp400-6
Abstract
Reprint
Full Text
Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes
C. S. Lindestam Arlehamn, S. Paul, F. Mele, C. Huang, J. A. Greenbaum, R. Vita, J. Sidney, B. Peters, F. Sallusto, A. Sette
in Proc Natl Acad Sci U S A (2015) vol. 112 ppE147-55
Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies
A. Kabanova, L. Perez, D. Lilleri, J. Marcandalli, G. Agatic, S. Becattini, S. Preite, D. Fuschillo, E. Percivalle, F. Sallusto, G. Gerna, D. Corti, A. Lanzavecchia
in Proc Natl Acad Sci U S A (2014) vol. 111 pp17965-70
A.K. and L.P. contributed equally to this work.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations
L. Pappas, M. Foglierini, L. Piccoli, N. L. Kallewaard, F. Turrini, C. Silacci, B. Fernandez-Rodriguez, G. Agatic, I. Giacchetto-Sasselli, G. Pellicciotta, F. Sallusto, Q. Zhu, E. Vicenzi, D. Corti, A. Lanzavecchia
in Nature (2014) vol. 516 pp418-22
Davide Corti and Antonio Lanzavecchia equally contributed to this work.
FRT - Fondation Rene Touraine: Pour La Dermatologie
S. Sakaguchi, F. Sallusto, T. Gebhardt, G. Stingl, R. A. Clark, L. F. Santamaria-Babi, E. Guttman-Yassky, G. Schuler, H. J. Koenen
in Exp Dermatol (2014) vol. 23 pp772-85
The Oral Commensal Streptococcus mitis Shows a Mixed Memory Th Cell Signature That Is Similar to and Cross-Reactive with Streptococcus pneumoniae
S. A. Engen, H. Valen Rukke, S. Becattini, D. Jarrossay, I. J. Blix, F. C. Petersen, F. Sallusto, K. Schenck
in PLoS One (2014) vol. 9 ppe104306
Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors
S. L. Campion, T. M. Brodie, W. Fischer, B. T. Korber, A. Rossetti, N. Goonetilleke, A. J. McMichael, F. Sallusto
in J Exp Med (2014) vol. 211 pp1273-80
The many faces of CD4 T cells: Roles in immunity and disease
F. Sallusto, S. Monticelli
in Semin Immunol (2013) vol. 25 pp249-51
The who's who of T-cell differentiation: Human memory T-cell subsets
Y. D. Mahnke, T. M. Brodie, F. Sallusto, M. Roederer, E. Lugli
in Eur J Immunol (2013) vol. 43 pp2797-809
DCs: a dual bridge to protective immunity
F. Sallusto
in Nat Immunol (2013) vol. 14 pp890-1
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody
D. Corti, S. Bianchi, F. Vanzetta, A. Minola, L. Perez, G. Agatic, B. Guarino, C. Silacci, J. Marcandalli, B. J. Marsland, A. Piralla, E. Percivalle, F. Sallusto, F. Baldanti, A. Lanzavecchia
in Nature (2013) vol. 501 pp439-43
A functional BCR in human IgA and IgM plasma cells
D. Pinto, E. Montani, M. Bolli, G. Garavaglia, F. Sallusto, A. Lanzavecchia, D. Jarrossay
in Blood (2013) vol. 121 pp4110-4
Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection
D. Lilleri, A. Kabanova, M. G. Revello, E. Percivalle, A. Sarasini, E. Genini, F. Sallusto, A. Lanzavecchia, D. Corti, G. Gerna
in PLoS One (2013) vol. 8 ppe59863
OMIP-018: Chemokine receptor expression on human T helper cells
T. Brodie, E. Brenna, F. Sallusto
in Cytometry A (2013) vol. 83 pp530-2
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
D. Baumjohann, S. Preite, A. Reboldi, F. Ronchi, K. M. Ansel, A. Lanzavecchia, F. Sallusto
in Immunity (2013) vol. 38 pp596-605
Dirk Baumjohann and Federica Sallusto are co-corresponding authors.
Therapeutic Efficacy of Antibodies Lacking FcgammaR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies
K. L. Williams, S. Sukupolvi-Petty, M. Beltramello, S. Johnson, F. Sallusto, A. Lanzavecchia, M. S. Diamond, E. Harris
in PLoS Pathog (2013) vol. 9 ppe1003157
Formal Correction: There is an error in the article title, which is missing the word "binding". The title should instead read: "Therapeutic Efficacy of Antibodies Lacking Fcγ Receptor Binding against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies"
Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
L. Simonelli, M. Pedotti, M. Beltramello, E. Livoti, L. Calzolai, F. Sallusto, A. Lanzavecchia, L. Varani
in PLoS One (2013) vol. 8 ppe55561
Luca Simonelli, Mattia Pedotti contributed equally to this work.
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset
C. S. Lindestam Arlehamn, A. Gerasimova, F. Mele, R. Henderson, J. Swann, J. A. Greenbaum, Y. Kim, J. Sidney, E. A. James, R. Taplitz, D. M. McKinney, W. W. Kwok, H. Grey, F. Sallusto, B. Peters, A. Sette
in PLoS Pathog (2013) vol. 9 ppe1003130
Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
G. Di Zenzo, G. Di Lullo, D. Corti, V. Calabresi, A. Sinistro, F. Vanzetta, B. Didona, G. Cianchini, M. Hertl, R. Eming, M. Amagai, B. Ohyama, T. Hashimoto, J. Sloostra, F. Sallusto, G. Zambruno, A. Lanzavecchia
in J Clin Invest (2012) vol. 122 pp3781-90
Giovanni Di Zenzo, Giulia Di Lullo, and Davide Corti contributed equally to this work.
IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
S. Vigne, G. Palmer, P. Martin, C. Lamacchia, D. Strebel, E. Rodriguez, M. L. Olleros, D. Vesin, I. Garcia, F. Ronchi, F. Sallusto, J. E. Sims, C. Gabay
in Blood (2012) vol. 120 pp3478-87
Human Th17 subsets
F. Sallusto, C. E. Zielinski, A. Lanzavecchia
in Eur J Immunol (2012) vol. 42 pp2215-20
miR-146a and NF-kappaB1 Regulate Mast Cell Survival and T Lymphocyte Differentiation
N. Rusca, L. Deho, S. Montagner, C. E. Zielinski, A. Sica, F. Sallusto, S. Monticelli
in Mol Cell Biol (2012) vol. 32 pp4432-44
* Selected as "Article of significant interest" by the Editors
Negative regulators take center stage
S. Monticelli, F. Sallusto
in Nat Immunol (2012) vol. 13 pp719-20
T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts
C. Oseroff, J. Sidney, R. Vita, V. Tripple, D. M. McKinney, S. Southwood, T. M. Brodie, F. Sallusto, H. Grey, R. Alam, D. Broide, J. A. Greenbaum, R. Kolla, B. Peters, A. Sette
in J Immunol (2012) vol. 189 pp1800-11
T-cell trafficking in the central nervous system
F. Sallusto, D. Impellizzieri, C. Basso, A. Laroni, A. Uccelli, A. Lanzavecchia, B. Engelhardt
in Immunol Rev (2012) vol. 248 pp216-27
Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
C. E. Gomez, B. Perdiguero, V. Jimenez, A. Filali-Mouhim, K. Ghneim, E. K. Haddad, E. D. Quakkerlaar, J. Delaloye, A. Harari, T. Roger, T. Dunhen, R. P. Sekaly, C. J. Melief, T. Calandra, F. Sallusto, A. Lanzavecchia, R. Wagner, G. Pantaleo, M. Esteban
in PLoS One (2012) vol. 7 ppe35485
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto
in Nature (2012) vol. 484 pp514-8
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
T. Duhen, R. Duhen, A. Lanzavecchia, F. Sallusto, D. J. Campbell
in Blood (2012) vol. 119 pp4430-40
Ralph M. Steinman 1943-2011
A. Lanzavecchia, F. Sallusto
in Cell (2011) vol. 147 pp1216-7
Memory in disguise
F. Sallusto, A. Lanzavecchia
in Nat Med (2011) vol. 17 pp1182-3
IL-36R ligands are potent regulators of dendritic and T cells
S. Vigne, G. Palmer, C. Lamacchia, P. Martin, D. Talabot-Ayer, E. Rodriguez, F. Ronchi, F. Sallusto, H. Dinh, J. E. Sims, C. Gabay
in Blood (2011) vol. 118 pp5813-23
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, P. Collins, L. F. Haire, N. Temperton, J. P. Langedijk, J. J. Skehel, A. Lanzavecchia
in Science (2011) vol. 333 pp850-6
Davide Corti, Jarrod Voss, Steven J. Gamblin, Giosiana Codoni contributed equally to this work. John J. Skehel and Antonio Lanzavecchia are co-corresponding authors.
T regulatory cells are markers of disease activity in multiple sclerosis patients
D. Dalla Libera, D. Di Mitri, A. Bergami, D. Centonze, C. Gasperini, M. G. Grasso, S. Galgani, V. Martinelli, G. Comi, C. Avolio, G. Martino, G. Borsellino, F. Sallusto, L. Battistini, R. Furlan
in PLoS One (2011) vol. 6 ppe21386
In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection
R. de Alwis, M. Beltramello, W. B. Messer, S. Sukupolvi-Petty, W. M. Wahala, A. Kraus, N. P. Olivarez, Q. Pham, J. Brian, W. Y. Tsai, W. K. Wang, S. Halstead, S. Kliks, M. S. Diamond, R. Baric, A. Lanzavecchia, F. Sallusto, A. M. de Silva
in PLoS Negl Trop Dis (2011) vol. 5 ppe1188
High throughput cellular screens to interrogate the human T and B cell repertoires
D. Corti, F. Sallusto, A. Lanzavecchia
in Curr Opin Immunol (2011) vol. 23 pp430-5
An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV
J. D. Watkins, N. B. Siddappa, S. K. Lakhashe, M. Humbert, A. Sholukh, G. Hemashettar, Y. L. Wong, J. K. Yoon, W. Wang, F. J. Novembre, F. Villinger, C. Ibegbu, K. Patel, D. Corti, G. Agatic, F. Vanzetta, S. Bianchi, J. L. Heeney, F. Sallusto, A. Lanzavecchia, R. M. Ruprecht
in PLoS One (2011) vol. 6 ppe18207
Jennifer D. Watkins, Nagadenahalli B. Siddappa contributed equally to this work.
CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses
N. Chevalier, D. Jarrossay, E. Ho, D. T. Avery, C. S. Ma, D. Yu, F. Sallusto, S. G. Tangye, C. R. Mackay
in J Immunol (2011) vol. 186 pp5556-68
Dissecting the human immunologic memory for pathogens
C. E. Zielinski, D. Corti, F. Mele, D. Pinto, A. Lanzavecchia, F. Sallusto
in Immunol Rev (2011) vol. 240 pp40-51
Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
E. D. Quakkelaar, A. Redeker, E. K. Haddad, A. Harari, S. M. McCaughey, T. Duhen, A. Filali-Mouhim, J. P. Goulet, N. M. Loof, F. Ossendorp, B. Perdiguero, P. Heinen, C. E. Gomez, K. V. Kibler, D. M. Koelle, R. P. Sekaly, F. Sallusto, A. Lanzavecchia, G. Pantaleo, M. Esteban, J. Tartaglia, B. L. Jacobs, C. J. Melief
in PLoS One (2011) vol. 6 ppe16819
Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
Z. Kou, J. Y. Lim, M. Beltramello, M. Quinn, H. Chen, S. N. Liu, L. Martnez-Sobrido, M. S. Diamond, J. J. Schlesinger, A. de Silva, F. Sallusto, X. Jin
in Virology (2011) vol. 410 pp240-7
Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41
C. Sabin, D. Corti, V. Buzon, M. S. Seaman, D. Lutje Hulsik, A. Hinz, F. Vanzetta, G. Agatic, C. Silacci, L. Mainetti, G. Scarlatti, F. Sallusto, R. Weiss, A. Lanzavecchia, W. Weissenhorn
in PLoS Pathog (2010) vol. 6 ppe1001195
Charles Sabin, Davide Corti, Victor Buzon equally contributed to this work.
CD4(+) CD25(+) Treg regulate the contribution of CD8(+) T-cell subsets in repopulation of the lymphopenic environment
A. R. Almeida, I. F. Ciernik, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2010) vol. 40 pp3478-88
From vaccines to memory and back
F. Sallusto, A. Lanzavecchia, K. Araki, R. Ahmed
in Immunity (2010) vol. 33 pp451-63
Federica Sallusto and Rafi Ahmed are co-corresponding authors.
Monocytes join the dendritic cell family
F. Sallusto, A. Lanzavecchia
in Cell (2010) vol. 143 pp339-40
Federica Sallusto and Antonio Lanzavecchia are co-corresponding authors.
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
M. Beltramello, K. L. Williams, C. P. Simmons, A. Macagno, L. Simonelli, N. T. Quyen, S. Sukupolvi-Petty, E. Navarro-Sanchez, P. R. Young, A. M. de Silva, F. A. Rey, L. Varani, S. S. Whitehead, M. S. Diamond, E. Harris, A. Lanzavecchia, F. Sallusto
in Cell Host Microbe (2010) vol. 8 pp271-83
Antonio Lanzavecchia and Federica Sallusto are co-corresponding authors.
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
S. F. Martin, P. R. Esser, S. Schmucker, L. Dietz, D. J. Naisbitt, B. K. Park, M. Vocanson, J. F. Nicolas, M. Keller, W. J. Pichler, M. Peiser, A. Luch, R. Wanner, E. Maggi, A. Cavani, T. Rustemeyer, A. Richter, H. J. Thierse, F. Sallusto
in Cell Mol Life Sci (2010) vol. 67 pp4171-84
Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
D. Corti, A. L. Suguitan, D. Pinna, C. Silacci, B. M. Fernandez-Rodriguez, F. Vanzetta, C. Santos, C. J. Luke, F. J. Torres-Velez, N. J. Temperton, R. A. Weiss, F. Sallusto, K. Subbarao, A. Lanzavecchia
in J Clin Invest (2010) vol. 120 pp1663-73
Davide Corti and Amorsolo L. Suguitan Jr. contributed equally to this work.
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
L. Rivino, P. Gruarin, B. Haringer, S. Steinfelder, L. Lozza, B. Steckel, A. Weick, E. Sugliano, D. Jarrossay, A. A. Kuhl, C. Loddenkemper, S. Abrignani, F. Sallusto, A. Lanzavecchia, J. Geginat
in J Exp Med (2010) vol. 207 pp565-77
P. Gruarin and B. Häringer contributed equally to this paper.
Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
D. Corti, J. P. Langedijk, A. Hinz, M. S. Seaman, F. Vanzetta, B. M. Fernandez-Rodriguez, C. Silacci, D. Pinna, D. Jarrossay, S. Balla-Jhagjhoorsingh, B. Willems, M. J. Zekveld, H. Dreja, E. O'Sullivan, C. Pade, C. Orkin, S. A. Jeffs, D. C. Montefiori, D. Davis, W. Weissenhorn, A. McKnight, J. L. Heeney, F. Sallusto, Q. J. Sattentau, R. A. Weiss, A. Lanzavecchia
in PLoS One (2010) vol. 5 ppe8805
Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
A. Macagno, N. L. Bernasconi, F. Vanzetta, E. Dander, A. Sarasini, M. G. Revello, G. Gerna, F. Sallusto, A. Lanzavecchia
in J Virol (2010) vol. 84 pp1005-13
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2009) vol. 39 pp2076-82
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
T. Duhen, R . Geiger, D. Jarrossay, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2009) vol. 10 pp857-63
Thomas Duhen and Rebekka Geiger contributed equally to this work.
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
R . Geiger, T. Duhen, A. Lanzavecchia, F. Sallusto
in J Exp Med (2009) vol. 206 pp1525-34
Human B cell memory
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2009) vol. 21 pp298-304
Clonal dissection of the human memory B-cell repertoire following infection and vaccination
D. Pinna, D. Corti, D. Jarrossay, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2009) vol. 39 pp1260-70
Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
G. Napolitani, E. V. Acosta-Rodriguez, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2009) vol. 39 pp1301-12
Giorgio Napolitani, Eva V. Acosta-Rodriguez contributed equally to this work.
Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets
S. Khurana, A. L. Suguitan, Y. Rivera, C. P. Simmons, A. Lanzavecchia, F. Sallusto, J. Manischewitz, L. R. King, K. Subbarao, H. Golding
in PLoS Med (2009) vol. 6 ppe1000049
Human Th17 cells in infection and autoimmunity
F. Sallusto, A. Lanzavecchia
in Microbes Infect (2009) vol. 11 pp620-4
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto
in Nat Immunol (2009) vol. 10 pp514-23
Dendritic cell migration to peripheral lymph nodes
A. Martin-Fontecha, A. Lanzavecchia, F. Sallusto
in Handb Exp Pharmacol (2009) pp31-49
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
A. Martin-Fontecha, D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, F. Sallusto
in J Exp Med (2008) vol. 205 pp2561-74
Alfonso Martín-Fontecha and Federica Sallusto are co-correspondign authors.
Phenotype and function of human T lymphocyte subsets: consensus and issues
V. Appay, R. A. van Lier, F. Sallusto, M. Roederer
in Cytometry A (2008) vol. 73 pp975-83
Chemokines and leukocyte traffic
F. Sallusto, M. Baggiolini
in Nat Immunol (2008) vol. 9 pp949-52
Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation
C. Gregoire, C. Cognet, L. Chasson, C. A. Coupet, M. Dalod, A. Reboldi, J. Marvel, F. Sallusto, E. Vivier, T. Walzer
in Eur J Immunol (2008) vol. 38 pp2076-84
The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
L. Lozza, L. Rivino, G. Guarda, D. Jarrossay, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia, J. Geginat
in Eur J Immunol (2008) vol. 38 pp30-9
Human monoclonal antibodies by immortalization of memory B cells
A. Lanzavecchia, D. Corti, F. Sallusto
in Curr Opin Biotechnol (2007) vol. 18 pp523-8
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp942-9
Federica Sallusto and Eva Acosta are co-corresponding authors.
Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate
S. L. Reiner, F. Sallusto, A. Lanzavecchia
in Science (2007) vol. 317 pp622-5
Steven L. Reiner, Federica Sallusto, Antonio Lanzavecchia are corresponding authors.
Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
C. P. Simmons, N. L. Bernasconi, A. L. Suguitan, K. Mills, J. M. Ward, N. V. Chau, T. T. Hien, F. Sallusto, Q. Ha do, J. Farrar, M. D. de Jong, A. Lanzavecchia, K. Subbarao
in PLoS Med (2007) vol. 4 ppe178
Cameron P. Simmons, Nadia L. Bernasconi, Amorsolo L. Suguitan Jr., Kimberly Mills contribuited equally to this work; Antonio Lanzavecchia and Kanta Subbarao are co-corresponding authors.
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
G. Guarda, M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martin-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp743-52
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
E. V. Acosta-Rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, G. Napolitani
in Nat Immunol (2007) vol. 8 pp639-46
Federica Sallusto and Giorgio Napolitani are co-corresponding authors.
Toll-like receptors and innate immunity in B-cell activation and antibody responses
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2007) vol. 19 pp268-74
Duration, combination and timing: the signal integration model of dendritic cell activation
A. Macagno, G. Napolitani, A. Lanzavecchia, F. Sallusto
in Trends Immunol (2007) vol. 28 pp227-33
Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
L. Barfod, N. L. Bernasconi, M. Dahlback, D. Jarrossay, P. H. Andersen, A. Salanti, M. F. Ofori, L. Turner, M. Resende, M. A. Nielsen, T. G. Theander, F. Sallusto, A. Lanzavecchia, L. Hviid
in Mol Microbiol (2007) vol. 63 pp335-47
Lea Barfod and Nadia Bernasconi contributed equally to this work.
A new role for CCR5 in innate immunity--binding to bacterial heat shock protein 70
C. R. Mackay, F. Sallusto
in Eur J Immunol (2006) vol. 36 pp2293-5
Understanding and making use of human memory B cells
A. Lanzavecchia, N. Bernasconi, E. Traggiai, C. R. Ruprecht, D. Corti, F. Sallusto
in Immunol Rev (2006) vol. 211 pp303-9
Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
A. U. Rasheed, H. P. Rahn, F. Sallusto, M. Lipp, G. Muller
in Eur J Immunol (2006) vol. 36 pp1892-903
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
A. Macagno, M. Molteni, A. Rinaldi, F. Bertoni, A. Lanzavecchia, C. Rossetti, F. Sallusto
in J Exp Med (2006) vol. 203 pp1481-92
Annalisa Macagno and Federica Sallusto are co-corresponding authors.
Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets
T. Chtanova, R. Newton, S. M. Liu, L. Weininger, T. R. Young, D. G. Silva, F. Bertoni, A. Rinaldi, S. Chappaz, F. Sallusto, M. S. Rolph, C. R. Mackay
in J Immunol (2005) vol. 175 pp7837-47
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
G. Napolitani, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia
in Nat Immunol (2005) vol. 6 pp769-76
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
C. R. Ruprecht, M. Gattorno, F. Ferlito, A. Gregorio, A. Martini, A. Lanzavecchia, F. Sallusto
in J Exp Med (2005) vol. 201 pp1793-803
Understanding the generation and function of memory T cell subsets
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2005) vol. 17 pp326-32
Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
S. Casati, P. Aeby, D. A. Basketter, A. Cavani, A. Gennari, G. F. Gerberick, P. Griem, T. Hartung, I. Kimber, J. P. Lepoittevin, B. J. Meade, M. Pallardy, N. Rougier, F. Rousset, G. Rubinstenn, F. Sallusto, G. R. Verheyen, V. Zuang
in Altern Lab Anim (2005) vol. 33 pp47-62
Sliding doors in the immune response
F. Sallusto, S. L. Reiner
in Nat Immunol (2005) vol. 6 pp10-2
Lead and follow: the dance of the dendritic cell and T cell
A. Lanzavecchia, F. Sallusto
in Nat Immunol (2004) vol. 5 pp1201-2
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
A. Martin-Fontecha, L. L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2004) vol. 5 pp1260-5
Alfonso Martin-Fontecha and Federica Sallusto are co-corresponding authors.
Chemoattractants and their receptors in homeostasis and inflammation
F. Sallusto, C. R. Mackay
in Curr Opin Immunol (2004) vol. 16 pp724-31
Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells
L. Rivino, M. Messi, D. Jarrossay, A. Lanzavecchia, F. Sallusto, J. Geginat
in J Exp Med (2004) vol. 200 pp725-35
L. Rivino, M. Messi, and D. Jarrossay contributed equally to this work.
Central memory and effector memory T cell subsets: function, generation, and maintenance
F. Sallusto, J. Geginat, A. Lanzavecchia
in Annu Rev Immunol (2004) vol. 22 pp745-63
Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
A. Martin-Fontecha, S. Sebastiani, U. E. Hopken, M. Uguccioni, M. Lipp, A. Lanzavecchia, F. Sallusto
in J Exp Med (2003) vol. 198 pp615-21
Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells
J. Geginat, F. Sallusto, A. Lanzavecchia
in Pathol Biol (Paris) (2003) vol. 51 pp64-6
Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells
A. Langenkamp, K. Nagata, K. Murphy, L. Wu, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2003) vol. 33 pp474-82
T cell fitness determined by signal strength
A. V. Gett, F. Sallusto, A. Lanzavecchia, J. Geginat
in Nat Immunol (2003) vol. 4 pp355-60
Antonio Lanzavecchia and Jens Geginat are co-corresponding authors.
Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
J. Geginat, A. Lanzavecchia, F. Sallusto
in Blood (2003) vol. 101 pp4260-6
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
M. Messi, I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, F. Sallusto
in Nat Immunol (2003) vol. 4 pp78-86
Progressive differentiation and selection of the fittest in the immune response
A. Lanzavecchia, F. Sallusto
in Nat Rev Immunol (2002) vol. 2 pp982-7
TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
J. Geginat, S. Campagnaro, F. Sallusto, A. Lanzavecchia
in Adv Exp Med Biol (2002) vol. 512 pp107-12
T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
A. Langenkamp, G. Casorati, C. Garavaglia, P. Dellabona, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2002) vol. 32 pp2046-54
The instructive role of dendritic cells on T-cell responses
F. Sallusto, A. Lanzavecchia
in Arthritis Res (2002) vol. 4 Suppl 3 ppS127-32
Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
P. Ghia, G. Strola, L. Granziero, M. Geuna, G. Guida, F. Sallusto, N. Ruffing, L. Montagna, P. Piccoli, M. Chilosi, F. Caligaris-Cappio
in Eur J Immunol (2002) vol. 32 pp1403-13
Effects of the adjuvant cholera toxin on dendritic cells: stimulatory and inhibitory signals that result in the amplification of immune responses
M. C. Gagliardi, F. Sallusto, M. Marinaro, S. Vendetti, A. Riccomi, M. T. De Magistris
in Int J Med Microbiol (2002) vol. 291 pp571-5
Origin and migratory properties of dendritic cells in the skin
F. Sallusto
in Curr Opin Allergy Clin Immunol (2001) vol. 1 pp441-8
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
J. Geginat, F. Sallusto, A. Lanzavecchia
in J Exp Med (2001) vol. 194 pp1711-9
Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
D. Jarrossay, G. Napolitani, M. Colonna, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2001) vol. 31 pp3388-93
Exploring pathways for memory T cell generation
F. Sallusto, A. Lanzavecchia
in J Clin Invest (2001) vol. 108 pp805-6
Regulation of T cell immunity by dendritic cells
A. Lanzavecchia, F. Sallusto
in Cell (2001) vol. 106 pp263-6
Antonio Lanzavecchia and Federica Sallusto are co-corresponding authors.
Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells
P. Ghia, P. Transidico, J. P. Veiga, C. Schaniel, F. Sallusto, K. Matsushima, S. E. Sallan, A. G. Rolink, A. Mantovani, L. M. Nadler, A. A. Cardoso
in Blood (2001) vol. 98 pp533-40
The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2001) vol. 13 pp291-8
Antigen decoding by T lymphocytes: from synapses to fate determination
A. Lanzavecchia, F. Sallusto
in Nat Immunol (2001) vol. 2 pp487-92
Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma
C. Zelle-Rieser, A. L. Barsoum, F. Sallusto, R. Ramoner, J. W. Rohrer, L. Holtl, G. Bartsch, Jh Jr Coggin, M. Thurnher
in J Urol (2001) vol. 165 pp1705-9
Kinetics of GATA-3 gene expression in early polarizing and committed human T cells
E. Lantelme, S. Mantovani, B. Palermo, R. Campanelli, F. Sallusto, C. Giachino
in Immunology (2001) vol. 102 pp123-30
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
A. Langenkamp, M. Messi, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2000) vol. 1 pp311-6
Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
F. Sallusto, A. Lanzavecchia
in Immunol Rev (2000) vol. 177 pp134-40
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
D. Breitfeld, L. Ohl, E. Kremmer, J. Ellwart, F. Sallusto, M. Lipp, R. Forster
in J Exp Med (2000) vol. 192 pp1545-52
A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response
P. R. Dunbar, C. L. Smith, D. Chao, M. Salio, D. Shepherd, F. Mirza, M. Lipp, A. Lanzavecchia, F. Sallusto, A. Evans, R. Russell-Jones, A. L. Harris, V. Cerundolo
in J Immunol (2000) vol. 165 pp6644-52
Functional subsets of memory T cells identified by CCR7 expression
F. Sallusto, A. Langenkamp, J. Geginat, A. Lanzavecchia
in Curr Top Microbiol Immunol (2000) vol. 251 pp167-71
Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells
A. Lanzavecchia, F. Sallusto
in Science (2000) vol. 290 pp92-7
Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming
M. C. Gagliardi, F. Sallusto, M. Marinaro, A. Langenkamp, A. Lanzavecchia, M. T. De Magistris
in Eur J Immunol (2000) vol. 30 pp2394-403
The role of chemokine receptors in primary, effector, and memory immune responses
F. Sallusto, C. R. Mackay, A. Lanzavecchia
in Annu Rev Immunol (2000) vol. 18 pp593-620
A flavonoid sulfate antigen activates human alphabeta CD8+ Th2 lymphocytes in pollen allergy
F. Sallusto, R. Poupot, M. Clergue, R. DePalma, J. J. Fournie
in Eur J Immunol (2000) vol. 30 pp964-8
From synapses to immunological memory: the role of sustained T cell stimulation
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2000) vol. 12 pp92-8
The role of chemokines and chemokine receptors in T cell priming and Th1/Th2-mediated responses
F. Sallusto
in Haematologica (1999) vol. 84 Suppl EHA-4 pp28-31
Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation
A. Macagno, M. Gilliet, F. Sallusto, A. Lanzavecchia, F. O. Nestle, M. Groettrup
in Eur J Immunol (1999) vol. 29 pp4037-42
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
F. Sallusto, D. Lenig, R. Forster, M. Lipp, A. Lanzavecchia
in Nature (1999) vol. 401 pp708-12
Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation
C. Schaniel, F. Sallusto, C. Ruedl, P. Sideras, F. Melchers, A. G. Rolink
in Eur J Immunol (1999) vol. 29 pp2934-47
A novel CC chemokine ABCD-1, produced by dendritic cells and activated B cells, exclusively attracts activated T lymphocytes
C. Schaniel, F. Sallusto, P. Sideras, F. Melchers, A. G. Rolink
in Curr Top Microbiol Immunol (1999) vol. 246 pp95-101
The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells
F. Sallusto, B. Palermo, A. Hoy, A. Lanzavecchia
in Curr Top Microbiol Immunol (1999) vol. 246 pp123-8; discussion 129
Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
F. Sallusto, E. Kremmer, B. Palermo, A. Hoy, P. Ponath, S. Qin, R. Forster, M. Lipp, A. Lanzavecchia
in Eur J Immunol (1999) vol. 29 pp2037-45
Distinct patterns and kinetics of chemokine production regulate dendritic cell function
F. Sallusto, B. Palermo, D. Lenig, M. Miettinen, S. Matikainen, I. Julkunen, R. Forster, R. Burgstahler, M. Lipp, A. Lanzavecchia
in Eur J Immunol (1999) vol. 29 pp1617-25
Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
F. Sallusto, A. Lanzavecchia
in J Exp Med (1999) vol. 189 pp611-4
Use of antagonist peptides to inhibit in vitro T cell responses to Par j1, the major allergen of Parietaria judaica pollen
R. De Palma, S. Wu, F. Sallusto, G. Di Felice, P. Martucci, D. Geraci, P. Colombo, C. Troise, G. Sacerdoti, A. Nocera, J. Gorski
in J Immunol (1999) vol. 162 pp1982-7
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
F. Sallusto, A. Lanzavecchia, C. R. Mackay
in Immunol Today (1998) vol. 19 pp568-74
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
F. Sallusto, P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C. R. Mackay, S. Qin, A. Lanzavecchia
in Eur J Immunol (1998) vol. 28 pp2760-9
Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells
C. Schaniel, E. Pardali, F. Sallusto, M. Speletas, C. Ruedl, T. Shimizu, T. Seidl, J. Andersson, F. Melchers, A. G. Rolink, P. Sideras
in J Exp Med (1998) vol. 188 pp451-63
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
F. Sallusto, D. Lenig, C. R. Mackay, A. Lanzavecchia
in J Exp Med (1998) vol. 187 pp875-83
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
F. Sallusto, C. R. Mackay, A. Lanzavecchia
in Science (1997) vol. 277 pp2005-7
Major histocompatibility complex-independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ alpha/beta T cells
S. Corinti, R. D. De Palma, A. Fontana, M. C. Gagliardi, C. Pini, F. Sallusto
in J Exp Med (1997) vol. 186 pp899-908
Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles
R. Nisini, M. Paroli, D. Accapezzato, F. Bonino, F. Rosina, T. Santantonio, F. Sallusto, A. Amoroso, M. Houghton, V. Barnaba
in J Virol (1997) vol. 71 pp2241-51
Origin, maturation and antigen presenting function of dendritic cells
M. Cella, F. Sallusto, A. Lanzavecchia
in Curr Opin Immunol (1997) vol. 9 pp10-6
Ceramide inhibits antigen uptake and presentation by dendritic cells
F. Sallusto, C. Nicolo, R. De Maria, S. Corinti, R. Testi
in J Exp Med (1996) vol. 184 pp2411-6
Assessment of skin prick test and serum specific IgE detection in the diagnosis of Cupressaceae pollinosis
A. Mari, G. Di Felice, C. Afferni, B. Barletta, R. Tinghino, F. Sallusto, C. Pini
in J Allergy Clin Immunol (1996) vol. 98 pp21-31
Parietaria judaica-specific T-cell clones from atopic patients: heterogeneity in restriction, V beta usage, and cytokine profile
F. Sallusto, S. Corinti, C. Pini, M. M. Biocca, G. Bruno, G. Di Felice
in J Allergy Clin Immunol (1996) vol. 97 pp627-37
Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
S. Sozzani, F. Sallusto, W. Luini, D. Zhou, L. Piemonti, P. Allavena, J. Van Damme, S. Valitutti, A. Lanzavecchia, A. Mantovani
in J Immunol (1995) vol. 155 pp3292-5
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products
F. Sallusto, M. Cella, C. Danieli, A. Lanzavecchia
in J Exp Med (1995) vol. 182 pp389-400
Allergens of Arizona cypress (Cupressus arizonica) pollen: characterization of the pollen extract and identification of the allergenic components
G. Di Felice, M. F. Caiaffa, G. Bariletto, C. Afferni, R. Di Paola, A. Mari, S. Palumbo, R. Tinghino, F. Sallusto, A. Tursi, et al.
in J Allergy Clin Immunol (1994) vol. 94 pp547-55
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
F. Sallusto, A. Lanzavecchia
in J Exp Med (1994) vol. 179 pp1109-18
IgG subclass antibodies against Parietaria judaica in normal and allergic subjects
S. Palumbo, G. Di Felice, A. Mari, S. Bonini, G. Bruno, R. Tinghino, C. Afferni, F. Sallusto, C. Pini
in Allergy (1994) vol. 49 pp222-9
In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset
P. Dellabona, G. Casorati, B. Friedli, L. Angman, F. Sallusto, A. Tunnacliffe, E. Roosneek, A. Lanzavecchia
in J Exp Med (1993) vol. 177 pp1763-71
Purification and fine characterization of a major allergen from Olea europaea pollen extract
F. De Cesare, C. Pini, G. Di Felice, M. F. Caiaffa, L. Macchia, A. Tursi, R. Tinghino, S. Palumbo, F. Sallusto, R. Federico
in Allergy (1993) vol. 48 pp248-54
T-cell and antibody response to Parietaria judaica allergenic fractions in atopic and nonatopic individuals
F. Sallusto, F. Quintieri, O. Pugliese, G. Reale, C. Pini, G. Di Felice
in Allergy (1993) vol. 48 pp37-44