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Institute for Research in Biomedicine
Istituto di Ricerca in Biomedicina

Via Vincenzo Vela 6 - CH-6500 Bellinzona
Tel. +41 91 820 0300 - Fax +41 91 820 0302 - info [at] irb [dot] usi [dot] ch

Antonio Lanzavecchia, MD

Immune Regulation

Director

Via Vela, 6
6500 Bellinzona, Switzerland

Antonio Lanzavecchia
Bio

Antonio Lanzavecchia earned a degree in Medicine at the University of Pavia where he specialized in Paediatrics and in Infectious Diseases. From 1983 to 1999, he worked at the Basel Institute for Immunology and since 1999 he is the Director of the Institute for Research in Biomedicine in Bellinzona. He taught immunology at the Universities of Genova and Siena and since 2009 is Professor of Human Immunology at the Swiss Federal Institute of Technology ETH Zurich. He is Member of the EMBO and Fellow of the Royal College of Physicians. Awarded the EMBO medal in 1988 and the Cloëtta prize in 1999, Antonio Lanzavecchia published more than 270 papers. His research has covered several aspects of immunology: from antigen processing and presentation to dendritic cell biology, from lymphocyte activation and trafficking to T and B cell memory.

Publications
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
N. L. Kallewaard, D. Corti, P. J. Collins, U. Neu, J. M. McAuliffe, E. Benjamin, L. Wachter-Rosati, F. J. Palmer-Hill, A. Q. Yuan, P. A. Walker, M. K. Vorlaender, S. Bianchi, B. Guarino, A. De Marco, F. Vanzetta, G. Agatic, M. Foglierini, D. Pinna, B. Fernandez-Rodriguez, A. Fruehwirth, C. Silacci, R. W. Ogrodowicz, S. R. Martin, F. Sallusto, J. A. Suzich, A. Lanzavecchia, Q. Zhu, S. J. Gamblin, J. J. Skehel
in Cell (2016) vol. 166 pp596-608
Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, D. Corti
in Science (2016) vol. 353 pp823-6
K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
C. T. Ellebrecht, V. G. Bhoj, A. Nace, E. J. Choi, X. Mao, M. J. Cho, G. Di Zenzo, A. Lanzavecchia, J. T. Seykora, G. Cotsarelis, M. C. Milone, A. S. Payne
in Science (2016) vol. 353 pp179-84
Antibody-guided vaccine design: identification of protective epitopes
A. Lanzavecchia, A. Fruhwirth, L. Perez, D. Corti
in Curr Opin Immunol (2016) vol. 41 pp62-67
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
A. Kabanova, J. Marcandalli, T. Zhou, S. Bianchi, U. Baxa, Y. Tsybovsky, D. Lilleri, C. Silacci-Fregni, M. Foglierini, B. M. Fernandez-Rodriguez, A. Druz, B. Zhang, R. Geiger, M. Pagani, F. Sallusto, P. D. Kwong, D. Corti, A. Lanzavecchia, L. Perez
in Nat Microbiol (2016) vol. 1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells
F. Ronchi, C. Basso, S. Preite, A. Reboldi, D. Baumjohann, L. Perlini, A. Lanzavecchia, F. Sallusto
in Nat Commun (2016) vol. 7 pp11541
Francesca Ronchi and Camilla Basso equally contributed to this work.
Monoclonal antibodies to different components of the human cytomegalovirus (HCMV) pentamer gH/gL/pUL128L and trimer gH/gL/gO as well as antibodies elicited during primary HCMV infection prevent epithelial cell syncytium formation
G. Gerna, E. Percivalle, L. Perez, A. Lanzavecchia, D. Lilleri
in J Virol (2016) vol. 90 pp6216-23
Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome
D. Corti, N. Passini, A. Lanzavecchia, M. Zambon
in J Infect Public Health (2016) vol. 9 pp231-5
Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis
P. De Benedictis, A. Minola, E. Rota Nodari, R. Aiello, B. Zecchin, A. Salomoni, M. Foglierini, G. Agatic, F. Vanzetta, R. Lavenir, A. Lepelletier, E. Bentley, R. Weiss, G. Cattoli, I. Capua, F. Sallusto, E. Wright, A. Lanzavecchia, H. Bourhy, D. Corti
in EMBO Mol Med (2016) vol. 8 pp407-21
Paola De Benedictis and Andrea Minola equally contributed to this work.
SARS-like WIV1-CoV poised for human emergence
V. D. Menachery, B. L. Yount, A. C. Sims, K. Debbink, S. S. Agnihothram, L. E. Gralinski, R. L. Graham, T. Scobey, J. A. Plante, S. R. Royal, J. Swanstrom, T. P. Sheahan, R. J. Pickles, D. Corti, S. H. Randell, A. Lanzavecchia, W. A. Marasco, R. S. Baric
in Proc Natl Acad Sci U S A (2016) vol. 113 pp3048-53
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
D. Corti, J. Misasi, S. Mulangu, D. A. Stanley, M. Kanekiyo, S. Wollen, A. Ploquin, N. A. Doria-Rose, R. P. Staupe, M. Bailey, W. Shi, M. Choe, H. Marcus, E. A. Thompson, A. Cagigi, C. Silacci, B. Fernandez-Rodriguez, L. Perez, F. Sallusto, F. Vanzetta, G. Agatic, E. Cameroni, N. Kisalu, I. Gordon, J. E. Ledgerwood, J. R. Mascola, B. S. Graham, J. J. Muyembe-Tamfun, J. C. Trefry, A. Lanzavecchia, N. J. Sullivan
in Science (2016) vol. 351 pp1339-42
Davide Corti and John Misasi equally contributed to this work; John C. Trefry, Antonio Lanzavecchia, and Nancy J. Sullivan equally contributed to this work.
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
J. Misasi, M. S. Gilman, M. Kanekiyo, M. Gui, A. Cagigi, S. Mulangu, D. Corti, J. E. Ledgerwood, A. Lanzavecchia, J. Cunningham, J. J. Muyembe-Tamfun, U. Baxa, B. S. Graham, Y. Xiang, N. J. Sullivan, J. S. McLellan
in Science (2016) vol. 351 pp1343-6
John Misasi, Morgan S. A. Gilman, Masaru Kanekiyo, Miao Gui, equally contributed to this work; Ye Xiang, Nancy J. Sullivan, Jason S. McLellan equally contributed to this work.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
J. Tan, K. Pieper, L. Piccoli, A. Abdi, M. Foglierini, R. Geiger, C. M. Tully, D. Jarrossay, F. M. Ndungu, J. Wambua, P. Bejon, C. S. Fregni, B. Fernandez-Rodriguez, S. Barbieri, S. Bianchi, K. Marsh, V. Thathy, D. Corti, F. Sallusto, P. Bull, A. Lanzavecchia
in Nature (2016) vol. 529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
V. D. Menachery, B. L. Yount, K. Debbink, S. Agnihothram, L. E. Gralinski, J. A. Plante, R. L. Graham, T. Scobey, X. Y. Ge, E. F. Donaldson, S. H. Randell, A. Lanzavecchia, W. A. Marasco, Z. L. Shi, R. S. Baric
in Nat Med (2015) vol. 21 pp1508-13
Vineet D Menachery and Ralph Baric are co-corresponding authors.
Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells
S. Preite, D. Baumjohann, M. Foglierini, C. Basso, F. Ronchi, B. M. Rodriguez, D. Corti, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2015) vol. 45 pp3010-21
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
D. Corti, J. Zhao, M. Pedotti, L. Simonelli, S. Agnihothram, C. Fett, B. Fernandez-Rodriguez, M. Foglierini, G. Agatic, F. Vanzetta, R. Gopal, C. J. Langrish, N. A. Barrett, F. Sallusto, R. S. Baric, L. Varani, M. Zambon, S. Perlman, A. Lanzavecchia
in Proc Natl Acad Sci U S A (2015) vol. 112 pp10473-8
D.C. and J.Z. contributed equally to this work.
Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody
X. Xiong, D. Corti, J. Liu, D. Pinna, M. Foglierini, L. J. Calder, S. R. Martin, Y. P. Lin, P. A. Walker, P. J. Collins, I. Monne, A. L. Suguitan, C. Santos, N. J. Temperton, K. Subbarao, A. Lanzavecchia, S. J. Gamblin, J. J. Skehel
in Proc Natl Acad Sci U S A (2015) vol. 112 pp9430-5
X.X., D.C., and J.L. contributed equally to this work.
Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses
L. C. Lindesmith, M. Beltramello, J. Swanstrom, T. A. Jones, D. Corti, A. Lanzavecchia, R. S. Baric
in Open Forum Infect Dis (2015) vol. 2 ppofv084
Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
L. Piccoli, I. Campo, C. S. Fregni, B. M. Rodriguez, A. Minola, F. Sallusto, M. Luisetti, D. Corti, A. Lanzavecchia
in Nat Commun (2015) vol. 6 pp7375
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
T. Zhou, R. M. Lynch, L. Chen, P. Acharya, X. Wu, N. A. Doria-Rose, M. G. Joyce, D. Lingwood, C. Soto, R. T. Bailer, M. J. Ernandes, R. Kong, N. S. Longo, M. K. Louder, K. McKee, S. O'Dell, S. D. Schmidt, L. Tran, Z. Yang, A. Druz, T. S. Luongo, S. Moquin, S. Srivatsan, Y. Yang, B. Zhang, A. Zheng, M. Pancera, T. Kirys, I. S. Georgiev, T. Gindin, H. P. Peng, A. S. Yang, Nisc Comparative Sequencing Program, J. C. Mullikin, M. D. Gray, L. Stamatatos, D. R. Burton, W. C. Koff, M. S. Cohen, B. F. Haynes, J. P. Casazza, M. Connors, D. Corti, A. Lanzavecchia, Q. J. Sattentau, R. A. Weiss, A. P. West, P. J. Bjorkman, J. F. Scheid, M. C. Nussenzweig, L. Shapiro, J. R. Mascola, P. D. Kwong
in Cell (2015) vol. 161 pp1280-92
John R. Mascola, Peter D. Kwong are co-corresponding authors.
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
F. Mele, C. Basso, C. Leoni, D. Aschenbrenner, S. Becattini, D. Latorre, A. Lanzavecchia, F. Sallusto, S. Monticelli
in Nat Commun (2015) vol. 6 pp6431
Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge
A. M. Sholukh, J. D. Watkins, H. K. Vyas, S. Gupta, S. K. Lakhashe, S. Thorat, M. Zhou, G. Hemashettar, B. C. Bachler, D. N. Forthal, F. Villinger, Q. J. Sattentau, R. A. Weiss, G. Agatic, D. Corti, A. Lanzavecchia, J. L. Heeney, R. M. Ruprecht
in Vaccine (2015) vol. 33 pp2086-95
T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
S. Becattini, D. Latorre, F. Mele, M. Foglierini, C. De Gregorio, A. Cassotta, B. Fernandez, S. Kelderman, T. N. Schumacher, D. Corti, A. Lanzavecchia, F. Sallusto
in Science (2015) vol. 347 pp400-6
Abstract
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Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies
A. Kabanova, L. Perez, D. Lilleri, J. Marcandalli, G. Agatic, S. Becattini, S. Preite, D. Fuschillo, E. Percivalle, F. Sallusto, G. Gerna, D. Corti, A. Lanzavecchia
in Proc Natl Acad Sci U S A (2014) vol. 111 pp17965-70
A.K. and L.P. contributed equally to this work.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations
L. Pappas, M. Foglierini, L. Piccoli, N. L. Kallewaard, F. Turrini, C. Silacci, B. Fernandez-Rodriguez, G. Agatic, I. Giacchetto-Sasselli, G. Pellicciotta, F. Sallusto, Q. Zhu, E. Vicenzi, D. Corti, A. Lanzavecchia
in Nature (2014) vol. 516 pp418-22
Davide Corti and Antonio Lanzavecchia equally contributed to this work.
Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells
D. Corti, A. Lanzavecchia
in Microbiol Spectr (2014) vol. 2
Particle Conformation Regulates Antibody Access to a Conserved GII.4 Norovirus Blockade Epitope
L. C. Lindesmith, E. F. Donaldson, M. Beltramello, S. Pintus, D. Corti, J. Swanstrom, K. Debbink, T. A. Jones, A. Lanzavecchia, R. S. Baric
in J Virol (2014) vol. 88 pp8826-42
Within-Host Evolution Results in Antigenically Distinct GII.4 Noroviruses
K. Debbink, L. C. Lindesmith, M. T. Ferris, J. Swanstrom, M. Beltramello, D. Corti, A. Lanzavecchia, R. S. Baric
in J Virol (2014) vol. 88 pp7244-7255
The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells
S. Gupta, J. S. Gach, J. C. Becerra, T. B. Phan, J. Pudney, Z. Moldoveanu, S. B. Joseph, G. Landucci, M. J. Supnet, L. H. Ping, D. Corti, B. Moldt, Z. Hel, A. Lanzavecchia, R. M. Ruprecht, D. R. Burton, J. Mestecky, D. J. Anderson, D. N. Forthal
in PLoS Pathog (2013) vol. 9 ppe1003776
*Correction: http://www.plospathogens.org/annotation/listThread.action?root=75513
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody
D. Corti, S. Bianchi, F. Vanzetta, A. Minola, L. Perez, G. Agatic, B. Guarino, C. Silacci, J. Marcandalli, B. J. Marsland, A. Piralla, E. Percivalle, F. Sallusto, F. Baldanti, A. Lanzavecchia
in Nature (2013) vol. 501 pp439-43
Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity
K. Debbink, L. C. Lindesmith, E. F. Donaldson, V. Costantini, M. Beltramello, D. Corti, J. Swanstrom, A. Lanzavecchia, J. Vinje, R. S. Baric
in J Infect Dis (2013) vol. 208 pp1877-87
A functional BCR in human IgA and IgM plasma cells
D. Pinto, E. Montani, M. Bolli, G. Garavaglia, F. Sallusto, A. Lanzavecchia, D. Jarrossay
in Blood (2013) vol. 121 pp4110-4
Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection
D. Lilleri, A. Kabanova, M. G. Revello, E. Percivalle, A. Sarasini, E. Genini, F. Sallusto, A. Lanzavecchia, D. Corti, G. Gerna
in PLoS One (2013) vol. 8 ppe59863
Broadly neutralizing antiviral antibodies
D. Corti, A. Lanzavecchia
in Annu Rev Immunol (2013) vol. 31 pp705-42
* Complimentary one-time access to this article as PDF file is provided via the e-Print URL for your own personal use. Any further/multiple distribution, publication, or commercial usage of this copyrighted material requires submission of a permission request addressed to the Copyright Clearance Center (http://www.copyright.com/)
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
D. Baumjohann, S. Preite, A. Reboldi, F. Ronchi, K. M. Ansel, A. Lanzavecchia, F. Sallusto
in Immunity (2013) vol. 38 pp596-605
Dirk Baumjohann and Federica Sallusto are co-corresponding authors.
Therapeutic Efficacy of Antibodies Lacking FcgammaR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies
K. L. Williams, S. Sukupolvi-Petty, M. Beltramello, S. Johnson, F. Sallusto, A. Lanzavecchia, M. S. Diamond, E. Harris
in PLoS Pathog (2013) vol. 9 ppe1003157
Formal Correction: There is an error in the article title, which is missing the word "binding". The title should instead read: "Therapeutic Efficacy of Antibodies Lacking Fcγ Receptor Binding against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies"
Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
L. Simonelli, M. Pedotti, M. Beltramello, E. Livoti, L. Calzolai, F. Sallusto, A. Lanzavecchia, L. Varani
in PLoS One (2013) vol. 8 ppe55561
Luca Simonelli, Mattia Pedotti contributed equally to this work.
Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
G. Di Zenzo, G. Di Lullo, D. Corti, V. Calabresi, A. Sinistro, F. Vanzetta, B. Didona, G. Cianchini, M. Hertl, R. Eming, M. Amagai, B. Ohyama, T. Hashimoto, J. Sloostra, F. Sallusto, G. Zambruno, A. Lanzavecchia
in J Clin Invest (2012) vol. 122 pp3781-90
Giovanni Di Zenzo, Giulia Di Lullo, and Davide Corti contributed equally to this work.
Human Th17 subsets
F. Sallusto, C. E. Zielinski, A. Lanzavecchia
in Eur J Immunol (2012) vol. 42 pp2215-20
Antibodies against neutralization epitopes of human cytomegalovirus gH/gL/pUL128-130-131 complex and virus spreading may correlate with virus control in vivo
D. Lilleri, A. Kabanova, A. Lanzavecchia, G. Gerna
in J Clin Immunol (2012) vol. 32 pp1324-31
T-cell trafficking in the central nervous system
F. Sallusto, D. Impellizzieri, C. Basso, A. Laroni, A. Uccelli, A. Lanzavecchia, B. Engelhardt
in Immunol Rev (2012) vol. 248 pp216-27
Immunogenetic Mechanisms Driving Norovirus GII.4 Antigenic Variation
L. C. Lindesmith, M. Beltramello, E. F. Donaldson, D. Corti, J. Swanstrom, K. Debbink, A. Lanzavecchia, R. S. Baric
in PLoS Pathog (2012) vol. 8 ppe1002705
Lisa C. Lindesmith, Martina Beltramello contributed equally to this work.
Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
C. E. Gomez, B. Perdiguero, V. Jimenez, A. Filali-Mouhim, K. Ghneim, E. K. Haddad, E. D. Quakkerlaar, J. Delaloye, A. Harari, T. Roger, T. Dunhen, R. P. Sekaly, C. J. Melief, T. Calandra, F. Sallusto, A. Lanzavecchia, R. Wagner, G. Pantaleo, M. Esteban
in PLoS One (2012) vol. 7 ppe35485
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto
in Nature (2012) vol. 484 pp514-8
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
T. Duhen, R. Duhen, A. Lanzavecchia, F. Sallusto, D. J. Campbell
in Blood (2012) vol. 119 pp4430-40
Ralph M. Steinman 1943-2011
A. Lanzavecchia, F. Sallusto
in Cell (2011) vol. 147 pp1216-7
Characterization of Neutralizing Profiles in HIV-1 Infected Patients from whom the HJ16, HGN194 and HK20 mAbs were Obtained
S. S. Balla-Jhagjhoorsingh, B. Willems, L. Heyndrickx, K. Vereecken, W. Janssens, M. S. Seaman, D. Corti, A. Lanzavecchia, D. Davis, G. Vanham
in PLoS One (2011) vol. 6 ppe25488
Memory in disguise
F. Sallusto, A. Lanzavecchia
in Nat Med (2011) vol. 17 pp1182-3
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, P. Collins, L. F. Haire, N. Temperton, J. P. Langedijk, J. J. Skehel, A. Lanzavecchia
in Science (2011) vol. 333 pp850-6
Davide Corti, Jarrod Voss, Steven J. Gamblin, Giosiana Codoni contributed equally to this work. John J. Skehel and Antonio Lanzavecchia are co-corresponding authors.
In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection
R. de Alwis, M. Beltramello, W. B. Messer, S. Sukupolvi-Petty, W. M. Wahala, A. Kraus, N. P. Olivarez, Q. Pham, J. Brian, W. Y. Tsai, W. K. Wang, S. Halstead, S. Kliks, M. S. Diamond, R. Baric, A. Lanzavecchia, F. Sallusto, A. M. de Silva
in PLoS Negl Trop Dis (2011) vol. 5 ppe1188
High throughput cellular screens to interrogate the human T and B cell repertoires
D. Corti, F. Sallusto, A. Lanzavecchia
in Curr Opin Immunol (2011) vol. 23 pp430-5
An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV
J. D. Watkins, N. B. Siddappa, S. K. Lakhashe, M. Humbert, A. Sholukh, G. Hemashettar, Y. L. Wong, J. K. Yoon, W. Wang, F. J. Novembre, F. Villinger, C. Ibegbu, K. Patel, D. Corti, G. Agatic, F. Vanzetta, S. Bianchi, J. L. Heeney, F. Sallusto, A. Lanzavecchia, R. M. Ruprecht
in PLoS One (2011) vol. 6 ppe18207
Jennifer D. Watkins, Nagadenahalli B. Siddappa contributed equally to this work.
Dissecting the human immunologic memory for pathogens
C. E. Zielinski, D. Corti, F. Mele, D. Pinto, A. Lanzavecchia, F. Sallusto
in Immunol Rev (2011) vol. 240 pp40-51
Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
E. D. Quakkelaar, A. Redeker, E. K. Haddad, A. Harari, S. M. McCaughey, T. Duhen, A. Filali-Mouhim, J. P. Goulet, N. M. Loof, F. Ossendorp, B. Perdiguero, P. Heinen, C. E. Gomez, K. V. Kibler, D. M. Koelle, R. P. Sekaly, F. Sallusto, A. Lanzavecchia, G. Pantaleo, M. Esteban, J. Tartaglia, B. L. Jacobs, C. J. Melief
in PLoS One (2011) vol. 6 ppe16819
Strain-Transcending Fc-Dependent Killing of Plasmodium falciparum by Merozoite Surface Protein 2 Allele-Specific Human Antibodies
J. Stubbs, S. Olugbile, B. Saidou, J. Simpore, G. Corradin, A. Lanzavecchia
in Infect Immun (2011) vol. 79 pp1143-52
Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41
C. Sabin, D. Corti, V. Buzon, M. S. Seaman, D. Lutje Hulsik, A. Hinz, F. Vanzetta, G. Agatic, C. Silacci, L. Mainetti, G. Scarlatti, F. Sallusto, R. Weiss, A. Lanzavecchia, W. Weissenhorn
in PLoS Pathog (2010) vol. 6 ppe1001195
Charles Sabin, Davide Corti, Victor Buzon equally contributed to this work.
CD4(+) CD25(+) Treg regulate the contribution of CD8(+) T-cell subsets in repopulation of the lymphopenic environment
A. R. Almeida, I. F. Ciernik, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2010) vol. 40 pp3478-88
Chondroitin Sulfate A-Adhering Plasmodium falciparum-Infected Erythrocytes Express Functionally Important Antibody Epitopes Shared by Multiple Variants
L. Barfod, T. Dobrilovic, P. Magistrado, P. Khunrae, F. Viwami, J. Bruun, M. Dahlback, N. L. Bernasconi, M. Fried, D. John, P. E. Duffy, A. Salanti, A. Lanzavecchia, C. T. Lim, N. T. Ndam, M. K. Higgins, L. Hviid
in J Immunol (2010) vol. 185 pp7553-61
From vaccines to memory and back
F. Sallusto, A. Lanzavecchia, K. Araki, R. Ahmed
in Immunity (2010) vol. 33 pp451-63
Federica Sallusto and Rafi Ahmed are co-corresponding authors.
Monocytes join the dendritic cell family
F. Sallusto, A. Lanzavecchia
in Cell (2010) vol. 143 pp339-40
Federica Sallusto and Antonio Lanzavecchia are co-corresponding authors.
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
M. Beltramello, K. L. Williams, C. P. Simmons, A. Macagno, L. Simonelli, N. T. Quyen, S. Sukupolvi-Petty, E. Navarro-Sanchez, P. R. Young, A. M. de Silva, F. A. Rey, L. Varani, S. S. Whitehead, M. S. Diamond, E. Harris, A. Lanzavecchia, F. Sallusto
in Cell Host Microbe (2010) vol. 8 pp271-83
Antonio Lanzavecchia and Federica Sallusto are co-corresponding authors.
Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness
J. Pietzsch, J. F. Scheid, H. Mouquet, F. Klein, M. S. Seaman, M. Jankovic, D. Corti, A. Lanzavecchia, M. C. Nussenzweig
in J Exp Med (2010) vol. 207 pp1995-2002
Current Opinion in Immunology. Vaccines. Introduction
H. C. Ertl, A. Lanzavecchia
in Curr Opin Immunol (2010) vol. 22 pp355-7
Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
D. Corti, A. L. Suguitan, D. Pinna, C. Silacci, B. M. Fernandez-Rodriguez, F. Vanzetta, C. Santos, C. J. Luke, F. J. Torres-Velez, N. J. Temperton, R. A. Weiss, F. Sallusto, K. Subbarao, A. Lanzavecchia
in J Clin Invest (2010) vol. 120 pp1663-73
Davide Corti and Amorsolo L. Suguitan Jr. contributed equally to this work.
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
L. Rivino, P. Gruarin, B. Haringer, S. Steinfelder, L. Lozza, B. Steckel, A. Weick, E. Sugliano, D. Jarrossay, A. A. Kuhl, C. Loddenkemper, S. Abrignani, F. Sallusto, A. Lanzavecchia, J. Geginat
in J Exp Med (2010) vol. 207 pp565-77
P. Gruarin and B. Häringer contributed equally to this paper.
Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus
B. Rockx, E. Donaldson, M. Frieman, T. Sheahan, D. Corti, A. Lanzavecchia, R. S. Baric
in J Infect Dis (2010) vol. 201 pp946-55
Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
D. Corti, J. P. Langedijk, A. Hinz, M. S. Seaman, F. Vanzetta, B. M. Fernandez-Rodriguez, C. Silacci, D. Pinna, D. Jarrossay, S. Balla-Jhagjhoorsingh, B. Willems, M. J. Zekveld, H. Dreja, E. O'Sullivan, C. Pade, C. Orkin, S. A. Jeffs, D. C. Montefiori, D. Davis, W. Weissenhorn, A. McKnight, J. L. Heeney, F. Sallusto, Q. J. Sattentau, R. A. Weiss, A. Lanzavecchia
in PLoS One (2010) vol. 5 ppe8805
Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
A. Macagno, N. L. Bernasconi, F. Vanzetta, E. Dander, A. Sarasini, M. G. Revello, G. Gerna, F. Sallusto, A. Lanzavecchia
in J Virol (2010) vol. 84 pp1005-13
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2009) vol. 39 pp2076-82
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
T. Duhen, R . Geiger, D. Jarrossay, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2009) vol. 10 pp857-63
Thomas Duhen and Rebekka Geiger contributed equally to this work.
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
R . Geiger, T. Duhen, A. Lanzavecchia, F. Sallusto
in J Exp Med (2009) vol. 206 pp1525-34
Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein
D. Voss, S. Pfefferle, C. Drosten, L. Stevermann, E. Traggiai, A. Lanzavecchia, S. Becker
in Virol J (2009) vol. 6 pp79
Human B cell memory
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2009) vol. 21 pp298-304
Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
J. Soerli, L. Barfod, T. Lavstsen, N. L. Bernasconi, A. Lanzavecchia, L. Hviid
in Parasite Immunol (2009) vol. 31 pp341-6
Clonal dissection of the human memory B-cell repertoire following infection and vaccination
D. Pinna, D. Corti, D. Jarrossay, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2009) vol. 39 pp1260-70
Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
G. Napolitani, E. V. Acosta-Rodriguez, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2009) vol. 39 pp1301-12
Giorgio Napolitani, Eva V. Acosta-Rodriguez contributed equally to this work.
Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets
S. Khurana, A. L. Suguitan, Y. Rivera, C. P. Simmons, A. Lanzavecchia, F. Sallusto, J. Manischewitz, L. R. King, K. Subbarao, H. Golding
in PLoS Med (2009) vol. 6 ppe1000049
Human Th17 cells in infection and autoimmunity
F. Sallusto, A. Lanzavecchia
in Microbes Infect (2009) vol. 11 pp620-4
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto
in Nat Immunol (2009) vol. 10 pp514-23
Dendritic cell migration to peripheral lymph nodes
A. Martin-Fontecha, A. Lanzavecchia, F. Sallusto
in Handb Exp Pharmacol (2009) pp31-49
CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection
M. Cocco, C. Bellan, R. Tussiwand, D. Corti, E. Traggiai, S. Lazzi, S. Mannucci, L. Bronz, N. Palummo, C. Ginanneschi, P. Tosi, A. Lanzavecchia, M. G. Manz, L. Leoncini
in Am J Pathol (2008) vol. 173 pp1369-78
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
A. Martin-Fontecha, D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, F. Sallusto
in J Exp Med (2008) vol. 205 pp2561-74
Alfonso Martín-Fontecha and Federica Sallusto are co-correspondign authors.
Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells
G. De Falco, E. Leucci, A. Onnis, C. Bellan, C. Tigli, S. Wirths, G. Cerino, M. Cocco, D. Crupi, A. De Luca, A. Lanzavecchia, P. Tosi, L. Leoncini, A. Giordano
in J Cell Physiol (2008) vol. 215 pp276-82
Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge
B. Rockx, D. Corti, E. Donaldson, T. Sheahan, K. Stadler, A. Lanzavecchia, R. Baric
in J Virol (2008) vol. 82 pp3220-35
B.R. and D.C. contributed equally to this work.
The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
L. Lozza, L. Rivino, G. Guarda, D. Jarrossay, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia, J. Geginat
in Eur J Immunol (2008) vol. 38 pp30-9
Human monoclonal antibodies by immortalization of memory B cells
A. Lanzavecchia, D. Corti, F. Sallusto
in Curr Opin Biotechnol (2007) vol. 18 pp523-8
Pillars article: Antigen-specific interaction between T and B cells. 1985
A. Lanzavecchia
in J Immunol (2007) vol. 179 pp7206-8
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp942-9
Federica Sallusto and Eva Acosta are co-corresponding authors.
Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate
S. L. Reiner, F. Sallusto, A. Lanzavecchia
in Science (2007) vol. 317 pp622-5
Steven L. Reiner, Federica Sallusto, Antonio Lanzavecchia are corresponding authors.
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
Z. Zhu, S. Chakraborti, Y. He, A. Roberts, T. Sheahan, X. Xiao, L. E. Hensley, P. Prabakaran, B. Rockx, I. A. Sidorov, D. Corti, L. Vogel, Y. Feng, J. O. Kim, L. F. Wang, R. Baric, A. Lanzavecchia, K. M. Curtis, G. J. Nabel, K. Subbarao, S. Jiang, D. S. Dimitrov
in Proc Natl Acad Sci U S A (2007) vol. 104 pp12123-8
S.C., Y.H., A.R., T.S., and X.X. contributed equally to this work.
Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
C. P. Simmons, N. L. Bernasconi, A. L. Suguitan, K. Mills, J. M. Ward, N. V. Chau, T. T. Hien, F. Sallusto, Q. Ha do, J. Farrar, M. D. de Jong, A. Lanzavecchia, K. Subbarao
in PLoS Med (2007) vol. 4 ppe178
Cameron P. Simmons, Nadia L. Bernasconi, Amorsolo L. Suguitan Jr., Kimberly Mills contribuited equally to this work; Antonio Lanzavecchia and Kanta Subbarao are co-corresponding authors.
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
G. Guarda, M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martin-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2007) vol. 8 pp743-52
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
E. V. Acosta-Rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, G. Napolitani
in Nat Immunol (2007) vol. 8 pp639-46
Federica Sallusto and Giorgio Napolitani are co-corresponding authors.
Toll-like receptors and innate immunity in B-cell activation and antibody responses
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2007) vol. 19 pp268-74
Duration, combination and timing: the signal integration model of dendritic cell activation
A. Macagno, G. Napolitani, A. Lanzavecchia, F. Sallusto
in Trends Immunol (2007) vol. 28 pp227-33
Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
L. Barfod, N. L. Bernasconi, M. Dahlback, D. Jarrossay, P. H. Andersen, A. Salanti, M. F. Ofori, L. Turner, M. Resende, M. A. Nielsen, T. G. Theander, F. Sallusto, A. Lanzavecchia, L. Hviid
in Mol Microbiol (2007) vol. 63 pp335-47
Lea Barfod and Nadia Bernasconi contributed equally to this work.
Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue
M. Gattorno, L. Chicha, A. Gregorio, F. Ferlito, F. Rossi, D. Jarrossay, A. Lanzavecchia, A. Martini, M. G. Manz
in Rheumatology (Oxford) (2007) vol. 46 pp657-65
Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases
R. Ghittoni, G. Napolitani, D. Benati, C. Ulivieri, L. Patrussi, F. Laghi Pasini, A. Lanzavecchia, C. T. Baldari
in Eur J Immunol (2006) vol. 36 pp2885-93
Understanding and making use of human memory B cells
A. Lanzavecchia, N. Bernasconi, E. Traggiai, C. R. Ruprecht, D. Corti, F. Sallusto
in Immunol Rev (2006) vol. 211 pp303-9
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
A. Macagno, M. Molteni, A. Rinaldi, F. Bertoni, A. Lanzavecchia, C. Rossetti, F. Sallusto
in J Exp Med (2006) vol. 203 pp1481-92
Annalisa Macagno and Federica Sallusto are co-corresponding authors.
Toll-like receptor stimulation as a third signal required for activation of human naive B cells
C. R. Ruprecht, A. Lanzavecchia
in Eur J Immunol (2006) vol. 36 pp810-6
Regulation of peripheral T cell activation by calreticulin
S. Porcellini, E. Traggiai, U. Schenk, D. Ferrera, M. Matteoli, A. Lanzavecchia, M. Michalak, F. Grassi
in J Exp Med (2006) vol. 203 pp461-71
Characterization of severe acute respiratory syndrome coronavirus membrane protein
D. Voss, A. Kern, E. Traggiai, M. Eickmann, K. Stadler, A. Lanzavecchia, S. Becker
in FEBS Lett (2006) vol. 580 pp968-73
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
N. Onai, A. Obata-Onai, R. Tussiwand, A. Lanzavecchia, M. G. Manz
in J Exp Med (2006) vol. 203 pp227-38
N. Onai and A. Obata-Onai contributed equally to this work.
ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells
S. Wirths, A. Lanzavecchia
in Eur J Immunol (2005) vol. 35 pp3433-41
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
G. Napolitani, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia
in Nat Immunol (2005) vol. 6 pp769-76
Human adaptive immune system Rag2-/-gamma(c)-/- mice
L. Chicha, R. Tussiwand, E. Traggiai, L. Mazzucchelli, L. Bronz, J. C. Piffaretti, A. Lanzavecchia, M. G. Manz
in Ann N Y Acad Sci (2005) vol. 1044 pp236-43
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
C. R. Ruprecht, M. Gattorno, F. Ferlito, A. Gregorio, A. Martini, A. Lanzavecchia, F. Sallusto
in J Exp Med (2005) vol. 201 pp1793-803
Understanding the generation and function of memory T cell subsets
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2005) vol. 17 pp326-32
T cell costimulation by chemokine receptors
B. Molon, G. Gri, M. Bettella, C. Gomez-Mouton, A. Lanzavecchia, A. C. Martinez, S. Manes, A. Viola
in Nat Immunol (2005) vol. 6 pp465-71
Santos Manes and Antonella Viola are co-corresponding authors.
Immune subversion by Helicobacter pylori
C. T. Baldari, A. Lanzavecchia, J. L. Telford
in Trends Immunol (2005) vol. 26 pp199-207
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses
Z. Y. Yang, H. C. Werner, W. P. Kong, K. Leung, E. Traggiai, A. Lanzavecchia, G. J. Nabel
in Proc Natl Acad Sci U S A (2005) vol. 102 pp797-801
Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice
S. Feau, V. Facchinetti, F. Granucci, S. Citterio, D. Jarrossay, S. Seresini, M. P. Protti, A. Lanzavecchia, P. Ricciardi-Castagnoli
in Blood (2005) vol. 105 pp697-702
Lead and follow: the dance of the dendritic cell and T cell
A. Lanzavecchia, F. Sallusto
in Nat Immunol (2004) vol. 5 pp1201-2
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
A. Martin-Fontecha, L. L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, F. Sallusto
in Nat Immunol (2004) vol. 5 pp1260-5
Alfonso Martin-Fontecha and Federica Sallusto are co-corresponding authors.
Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells
L. Rivino, M. Messi, D. Jarrossay, A. Lanzavecchia, F. Sallusto, J. Geginat
in J Exp Med (2004) vol. 200 pp725-35
L. Rivino, M. Messi, and D. Jarrossay contributed equally to this work.
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
E. Traggiai, S. Becker, K. Subbarao, L. Kolesnikova, Y. Uematsu, M. R. Gismondo, B. R. Murphy, R. Rappuoli, A. Lanzavecchia
in Nat Med (2004) vol. 10 pp871-5
Development of a human adaptive immune system in cord blood cell-transplanted mice
E. Traggiai, L. Chicha, L. Mazzucchelli, L. Bronz, J. C. Piffaretti, A. Lanzavecchia, M. G. Manz
in Science (2004) vol. 304 pp104-7
Elisabetta Traggiai and Laurie Chicha contributed equally to this work.
Central memory and effector memory T cell subsets: function, generation, and maintenance
F. Sallusto, J. Geginat, A. Lanzavecchia
in Annu Rev Immunol (2004) vol. 22 pp745-63
Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
G. Napolitani, N. Bortoletto, L. Racioppi, A. Lanzavecchia, U. D'Oro
in Eur J Immunol (2003) vol. 33 pp2832-41
Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
A. Martin-Fontecha, S. Sebastiani, U. E. Hopken, M. Uguccioni, M. Lipp, A. Lanzavecchia, F. Sallusto
in J Exp Med (2003) vol. 198 pp615-21
Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells
J. Geginat, F. Sallusto, A. Lanzavecchia
in Pathol Biol (Paris) (2003) vol. 51 pp64-6
Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors
D. Hanahan, A. Lanzavecchia, E. Mihich
in Cancer Res (2003) vol. 63 pp3005-8
Antigen dependent and independent mechanisms that sustain serum antibody levels
E. Traggiai, R. Puzone, A. Lanzavecchia
in Vaccine (2003) vol. 21 Suppl 2 ppS35-7
Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells
A. Langenkamp, K. Nagata, K. Murphy, L. Wu, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2003) vol. 33 pp474-82
T cell fitness determined by signal strength
A. V. Gett, F. Sallusto, A. Lanzavecchia, J. Geginat
in Nat Immunol (2003) vol. 4 pp355-60
Antonio Lanzavecchia and Jens Geginat are co-corresponding authors.
Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
J. Geginat, A. Lanzavecchia, F. Sallusto
in Blood (2003) vol. 101 pp4260-6
A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
N. L. Bernasconi, N. Onai, A. Lanzavecchia
in Blood (2003) vol. 101 pp4500-4
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
M. Messi, I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, F. Sallusto
in Nat Immunol (2003) vol. 4 pp78-86
Maintenance of serological memory by polyclonal activation of human memory B cells
N. L. Bernasconi, E. Traggiai, A. Lanzavecchia
in Science (2002) vol. 298 pp2199-202
Nadia Bernasconi and Elisabetta Traggai contributed equally to this work.
A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding
J. Rachmilewitz, A. Lanzavecchia
in Trends Immunol (2002) vol. 23 pp592-5
Progressive differentiation and selection of the fittest in the immune response
A. Lanzavecchia, F. Sallusto
in Nat Rev Immunol (2002) vol. 2 pp982-7
TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
J. Geginat, S. Campagnaro, F. Sallusto, A. Lanzavecchia
in Adv Exp Med Biol (2002) vol. 512 pp107-12
Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells
N. Bortoletto, E. Scotet, Y. Myamoto, U. D'Oro, A. Lanzavecchia
in Eur J Immunol (2002) vol. 32 pp3102-7
T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
A. Langenkamp, G. Casorati, C. Garavaglia, P. Dellabona, A. Lanzavecchia, F. Sallusto
in Eur J Immunol (2002) vol. 32 pp2046-54
The instructive role of dendritic cells on T-cell responses
F. Sallusto, A. Lanzavecchia
in Arthritis Res (2002) vol. 4 Suppl 3 ppS127-32
Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes
H. Yoneyama, S. Narumi, Y. Zhang, M. Murai, M. Baggiolini, A. Lanzavecchia, T. Ichida, H. Asakura, K. Matsushima
in J Exp Med (2002) vol. 195 pp1257-66
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
A. Engering, T. B. Geijtenbeek, S. J. van Vliet, M. Wijers, E. van Liempt, N. Demaurex, A. Lanzavecchia, J. Fransen, C. G. Figdor, V. Piguet, Y. van Kooyk
in J Immunol (2002) vol. 168 pp2118-26
Lack of fair play in the T cell response
A. Lanzavecchia
in Nat Immunol (2002) vol. 3 pp9-10
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction
A. Dzionek, Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Gunther, I. Johnston, A. Lanzavecchia, T. Nagasaka, T. Okada, W. Vermi, G. Winkels, T. Yamamoto, M. Zysk, Y. Yamaguchi, J. Schmitz
in J Exp Med (2001) vol. 194 pp1823-34
A. Dzionek, Y. Sohma, and J. Nagafune contributed equally to this work. Y. Yamaguchi and J. Schmitz share senior authorship for this work.
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
J. Geginat, F. Sallusto, A. Lanzavecchia
in J Exp Med (2001) vol. 194 pp1711-9
Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8alpha(+) and CD8alpha(-) dendritic cells
L. Bruno, T. Seidl, A. Lanzavecchia
in Eur J Immunol (2001) vol. 31 pp3403-12
Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
D. Jarrossay, G. Napolitani, M. Colonna, F. Sallusto, A. Lanzavecchia
in Eur J Immunol (2001) vol. 31 pp3388-93
Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells
E. Scotet, S. Schroeder, A. Lanzavecchia
in Blood (2001) vol. 98 pp2568-70
Exploring pathways for memory T cell generation
F. Sallusto, A. Lanzavecchia
in J Clin Invest (2001) vol. 108 pp805-6
Regulation of T cell immunity by dendritic cells
A. Lanzavecchia, F. Sallusto
in Cell (2001) vol. 106 pp263-6
Antonio Lanzavecchia and Federica Sallusto are co-corresponding authors.
The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
A. Lanzavecchia, F. Sallusto
in Curr Opin Immunol (2001) vol. 13 pp291-8
Antigen decoding by T lymphocytes: from synapses to fate determination
A. Lanzavecchia, F. Sallusto
in Nat Immunol (2001) vol. 2 pp487-92
Migration and function of antigen-primed nonpolarized T lymphocytes in vivo
G. Iezzi, D. Scheidegger, A. Lanzavecchia
in J Exp Med (2001) vol. 193 pp987-93
Organization of plasma membrane functional rafts upon T cell activation
L. Tuosto, I. Parolini, S. Schroder, M. Sargiacomo, A. Lanzavecchia, A. Viola
in Eur J Immunol (2001) vol. 31 pp345-9
Antigen processing and recognition
P. Cresswell, A. Lanzavecchia
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Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
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Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
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Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
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A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response
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Functional subsets of memory T cells identified by CCR7 expression
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Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells
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Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming
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The role of chemokine receptors in primary, effector, and memory immune responses
F. Sallusto, C. R. Mackay, A. Lanzavecchia
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Cutting edge: recombinase-activating gene expression and V(D)J recombination in CD4+CD3low mature T lymphocytes
E. Lantelme, B. Palermo, L. Granziero, S. Mantovani, R. Campanelli, V. Monafo, A. Lanzavecchia, C. Giachino
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The role of aquaporins in dendritic cell macropinocytosis
A. de Baey, A. Lanzavecchia
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From synapses to immunological memory: the role of sustained T cell stimulation
A. Lanzavecchia, F. Sallusto
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Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
M. Salio, V. Cerundolo, A. Lanzavecchia
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Three signals and a master switch in the regulation of T-cell immunity
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Dendritic cell maturation and generation of immune responses
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Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation
A. Macagno, M. Gilliet, F. Sallusto, A. Lanzavecchia, F. O. Nestle, M. Groettrup
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The interplay between the duration of TCR and cytokine signaling determines T cell polarization
G. Iezzi, E. Scotet, D. Scheidegger, A. Lanzavecchia
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Inhibition of dendritic cell maturation by herpes simplex virus
M. Salio, M. Cella, M. Suter, A. Lanzavecchia
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
F. Sallusto, D. Lenig, R. Forster, M. Lipp, A. Lanzavecchia
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T-cell activation and the dynamic world of rafts
A. Viola, A. Lanzavecchia
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Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
M. Cella, D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, M. Colonna
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The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells
F. Sallusto, B. Palermo, A. Hoy, A. Lanzavecchia
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Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
F. Sallusto, E. Kremmer, B. Palermo, A. Hoy, P. Ponath, S. Qin, R. Forster, M. Lipp, A. Lanzavecchia
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Distinct patterns and kinetics of chemokine production regulate dendritic cell function
F. Sallusto, B. Palermo, D. Lenig, M. Miettinen, S. Matikainen, I. Julkunen, R. Forster, R. Burgstahler, M. Lipp, A. Lanzavecchia
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Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells
M. F. Bachmann, A. Gallimore, S. Linkert, V. Cerundolo, A. Lanzavecchia, M. Kopf, A. Viola
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Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
M. Cella, M. Salio, Y. Sakakibara, H. Langen, I. Julkunen, A. Lanzavecchia
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Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
F. Sallusto, A. Lanzavecchia
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From TCR engagement to T cell activation: a kinetic view of T cell behavior
A. Lanzavecchia, G. Lezzi, A. Viola
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T lymphocyte costimulation mediated by reorganization of membrane microdomains
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Peptide binding and editing: generation of TCR ligands
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Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
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From antigen presentation to T-cell activation
A. Lanzavecchia
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Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes
C. Giachino, E. Padovan, A. Lanzavecchia
in Eur J Immunol (1998) vol. 28 pp3506-13
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
F. Sallusto, P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C. R. Mackay, S. Qin, A. Lanzavecchia
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Immunology. Licence to kill
A. Lanzavecchia
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Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
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The duration of antigenic stimulation determines the fate of naive and effector T cells
G. Iezzi, K. Karjalainen, A. Lanzavecchia
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Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA
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Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering
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A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies
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The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells
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Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
F. Sallusto, C. R. Mackay, A. Lanzavecchia
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Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
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CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis
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Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation
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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition
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A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation
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Understanding the mechanisms of sustained signaling and T cell activation
A. Lanzavecchia
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Baculovirus cDNA libraries for expression cloning of genes encoding cell-surface antigens
L. Granziero, P. Nelboeck, M. Bedoucha, A. Lanzavecchia, H. H. Reid
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Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients
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Origin, maturation and antigen presenting function of dendritic cells
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Mannose receptor mediated antigen uptake and presentation in human dendritic cells
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Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients
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Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates
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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
M. Cella, D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, G. Alber
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T cell activation determined by T cell receptor number and tunable thresholds
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Mechanisms of antigen uptake for presentation
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Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
S. Valitutti, S. Muller, M. Dessing, A. Lanzavecchia
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Presentation of peptides by cultured monocytes or activated T cells allows specific priming of human cytotoxic T lymphocytes in vitro
M. C. Gagliardi, G. De Petrillo, S. Salemi, L. Boffa, M. G. Longobardi, P. Dellabona, G. Casorati, N. Tanigaki, R. Harris, A. Lanzavecchia, et al.
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Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products
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Dual receptor T-cells. Implications for alloreactivity and autoimmunity
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CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation
P. Lane, C. Burdet, F. McConnell, A. Lanzavecchia, E. Padovan
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How can cryptic epitopes trigger autoimmunity?
A. Lanzavecchia
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Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
P. D. Simitsek, D. G. Campbell, A. Lanzavecchia, N. Fairweather, C. Watts
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Serial triggering of many T-cell receptors by a few peptide-MHC complexes
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Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion
E. Padovan, C. Giachino, M. Cella, S. Valitutti, O. Acuto, A. Lanzavecchia
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kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire
C. Giachino, E. Padovan, A. Lanzavecchia
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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
S. Valitutti, M. Dessing, K. Aktories, H. Gallati, A. Lanzavecchia
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T cell epitope analysis with peptides simultaneously synthesized on cellulose membranes: fine mapping of two DQ dependent epitopes
S. Adler, R. Frank, A. Lanzavecchia, S. Weiss
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Peptide partners call the tune
A. Lanzavecchia, C. Watts
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An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells
P. Dellabona, E. Padovan, G. Casorati, M. Brockhaus, A. Lanzavecchia
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Clonal expansions of V delta 1+ and V delta 2+ cells increase with age and limit the repertoire of human gamma delta T cells
C. Giachino, L. Granziero, V. Modena, V. Maiocco, C. Lomater, F. Fantini, A. Lanzavecchia, N. Migone
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T-helper- and accessory-cell-independent cytotoxic responses to human tumor cells transfected with a B7 retroviral vector
C. Dohring, L. Angman, G. Spagnoli, A. Lanzavecchia
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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
F. Sallusto, A. Lanzavecchia
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Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles
D. Valmori, A. Sabbatini, A. Lanzavecchia, G. Corradin, P. M. Matricardi
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Professional presentation of antigen by activated human T cells
V. Barnaba, C. Watts, M. de Boer, P. Lane, A. Lanzavecchia
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Expression of two T cell receptor alpha chains: dual receptor T cells
E. Padovan, G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, A. Lanzavecchia
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Suppressive effect of antibody on processing of T cell epitopes
C. Watts, A. Lanzavecchia
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Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1
P. Lane, W. Gerhard, S. Hubele, A. Lanzavecchia, F. McConnell
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In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset
P. Dellabona, G. Casorati, B. Friedli, L. Angman, F. Sallusto, A. Tunnacliffe, E. Roosneek, A. Lanzavecchia
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Identifying strategies for immune intervention
A. Lanzavecchia
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Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility
S. Valitutti, M. Dessing, A. Lanzavecchia
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Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation
P. Lane, T. Brocker, S. Hubele, E. Padovan, A. Lanzavecchia, F. McConnell
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The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86
S. Demotz, C. Barbey, G. Corradin, A. Amoroso, A. Lanzavecchia
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Presentation of self-peptides: consequences for self nonself discrimination and allorecognition
S. Demotz, A. Lanzavecchia
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Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen
P. Panina-Bordignon, X. T. Fu, A. Lanzavecchia, R. W. Karr
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Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes
P. Lane, A. Traunecker, S. Hubele, S. Inui, A. Lanzavecchia, D. Gray
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T cell clones with normal or defective O-galactosylation from a patient with permanent mixed-field polyagglutinability
M. Thurnher, H. Clausen, W. Fierz, A. Lanzavecchia, E. G. Berger
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Irreversible association of peptides with class II MHC molecules in living cells
A. Lanzavecchia, P. A. Reid, C. Watts
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Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition
B. Boitel, M. Ermonval, P. Panina-Bordignon, R. A. Mariuzza, A. Lanzavecchia, O. Acuto
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Adoptive immunotherapy of ovarian carcinoma with bs-MAb-targeted lymphocytes: a multicenter study
R. L. Bolhuis, C. H. Lamers, S. H. Goey, A. M. Eggermont, J. B. Trimbos, G. Stoter, A. Lanzavecchia, E. di Re, S. Miotti, F. Raspagliesi, et al.
in Int J Cancer Suppl (1992) vol. 7 pp78-81
Janusin: new molecular design for bispecific reagents
A. Traunecker, A. Lanzavecchia, K. Karjalainen
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Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells
A. Traunecker, A. Lanzavecchia, K. Karjalainen
in EMBO J (1991) vol. 10 pp3655-9
Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes
H. W. Davidson, P. A. Reid, A. Lanzavecchia, C. Watts
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Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions
R. W. Karr, P. Panina-Bordignon, W. Y. Yu, A. Lanzavecchia
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Recognition by class II alloreactive T cells of processed determinants from human serum proteins
P. Panina-Bordignon, G. Corradin, E. Roosnek, A. Sette, A. Lanzavecchia
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Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cells
G. De Libero, G. Casorati, C. Giachino, C. Carbonara, N. Migone, P. Matzinger, A. Lanzavecchia
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Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells
E. Roosnek, A. Lanzavecchia
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Chemical and functional analysis of MHC class II-restricted T cell epitopes
C. Corradin, A. Lanzavecchia
in Int Rev Immunol (1991) vol. 7 pp139-47
Correlation between TCR V gene usage and antigen specificities in human gamma delta T cells
G. De Libero, G. Casorati, N. Migone, A. Lanzavecchia
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New perspectives on immunointervention in autoimmune diseases
L. Adorini, V. Barnaba, C. Bona, F. Celada, A. Lanzavecchia, E. Sercarz, N. Suciu-Foca, H. Wekerle
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T cell activation by a bispecific anti-CD3/anti-major histocompatibility complex class I antibody
E. Roosnek, A. Tunnacliffe, A. Lanzavecchia
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Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
A. Lanzavecchia
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Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways
S. Demotz, P. M. Matricardi, C. Irle, P. Panina, A. Lanzavecchia, G. Corradin
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Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells
P. Panina-Bordignon, A. Tan, A. Termijtelen, S. Demotz, G. Corradin, A. Lanzavecchia
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Molecular analysis of human gamma/delta+ clones from thymus and peripheral blood
G. Casorati, G. De Libero, A. Lanzavecchia, N. Migone
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A novel and simple procedure for determining T cell epitopes in protein antigens
S. Demotz, P. Matricardi, A. Lanzavecchia, G. Corradin
in J Immunol Methods (1989) vol. 122 pp67-72
Establishment of human double-positive thymocyte clones
G. De Libero, A. Lanzavecchia
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Triggering T cells by otherwise inert hybrid anti-CD3/antitumor antibodies requires encounter with the specific target cell
E. Roosnek, A. Lanzavecchia
in J Exp Med (1989) vol. 170 pp297-302
How many ways can a killer cell kill?
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in Int Rev Immunol (1989) vol. 4 pp109-14
Is suppression a function of class II--restricted cytotoxic T cells?
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in Immunol Today (1989) vol. 10 pp157-9
In vivo localization of a bispecific antibody which targets human T lymphocytes to lyse human colon cancer cells
I. G. Barr, S. Miescher, V. von Fliedner, F. Buchegger, C. Barras, A. Lanzavecchia, J. P. Mach, S. Carrel
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Delineation of several DR-restricted tetanus toxin T cell epitopes
S. Demotz, A. Lanzavecchia, U. Eisel, H. Niemann, C. Widmann, G. Corradin
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Harming and protecting responses to HIV
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Study on the immunogenicity of human class-II-restricted T-cell epitopes: processing constraints, degenerate binding, and promiscuous recognition
P. Panina-Bordignon, S. Demotz, G. Corradin, A. Lanzavecchia
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Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes
O. Krahenbuhl, C. Rey, D. Jenne, A. Lanzavecchia, P. Groscurth, S. Carrel, J. Tschopp
in J Immunol (1988) vol. 141 pp3471-7
Clonal sketches of the immune response
A. Lanzavecchia
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Activation of mononuclear cells to be used for hybrid monoclonal antibody-induced lysis of human ovarian carcinoma cells
S. M. Pupa, S. Canevari, R. Fontanelli, S. Menard, D. Mezzanzanica, A. Lanzavecchia, M. I. Colnaghi
in Int J Cancer (1988) vol. 42 pp455-9
T cells can present antigens such as HIV gp120 targeted to their own surface molecules
A. Lanzavecchia, E. Roosnek, T. Gregory, P. Berman, S. Abrignani
in Nature (1988) vol. 334 pp530-2
Kinetics of MHC-antigen complex formation on antigen-presenting cells
E. Roosnek, S. Demotz, G. Corradin, A. Lanzavecchia
in J Immunol (1988) vol. 140 pp4079-82
Exploiting the immune system's own strategies for immunotherapy
A. Lanzavecchia
in Immunol Today (1988) vol. 9 pp167-8
Human ovarian carcinoma lysis by cytotoxic T cells targeted by bispecific monoclonal antibodies: analysis of the antibody components
D. Mezzanzanica, S. Canevari, S. Menard, S. M. Pupa, E. Tagliabue, A. Lanzavecchia, M. I. Colnaghi
in Int J Cancer (1988) vol. 41 pp609-15
Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
A. Lanzavecchia, S. Abrignani, D. Scheidegger, R. Obrist, B. Dorken, G. Moldenhauer
in J Exp Med (1988) vol. 167 pp345-52
Anti-ovarian carcinoma anti-T3 heteroconjugates or hybrid antibodies induce tumor cell lysis by cytotoxic T-cells
S. Canevari, S. Menard, D. Mezzanzanica, S. Miotti, S. M. Pupa, A. Lanzavecchia, M. I. Colnaghi
in Int J Cancer Suppl (1988) vol. 2 pp18-21
Antigen uptake and accumulation in antigen-specific B cells
A. Lanzavecchia
in Immunol Rev (1987) vol. 99 pp39-51
Lysis of nonnucleated red blood cells by cytotoxic T lymphocytes
A. Lanzavecchia, U. D. Staerz
in Eur J Immunol (1987) vol. 17 pp1073-4
The use of hybrid hybridomas to target human cytotoxic T lymphocytes
A. Lanzavecchia, D. Scheidegger
in Eur J Immunol (1987) vol. 17 pp105-11
Advances in understanding of mechanisms of IgE disregulation in atopy by the application of in vitro methods
M. Ricci, G. F. Del Prete, E. Maggi, A. Lanzavecchia, S. Romagnani
in J Allergy Clin Immunol (1986) vol. 78 pp988-94
Is the T-cell receptor involved in T-cell killing?
A. Lanzavecchia
in Nature (1986) vol. 319 pp778-80
Antigen presentation by B lymphocytes: a critical step in T-B collaboration
A. Lanzavecchia
in Curr Top Microbiol Immunol (1986) vol. 130 pp65-78
Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis
F. Sinigaglia, D. Scheidegger, G. Garotta, R. Scheper, M. Pletscher, A. Lanzavecchia
in J Immunol (1985) vol. 135 pp3929-32
Specific B lymphocytes efficiently pick up, process and present antigen to T cells
A. Lanzavecchia, S. Bove
in Behring Inst Mitt (1985) pp82-7
Antigen-specific interaction between T and B cells
A. Lanzavecchia
in Nature (1985) vol. 314 pp537-9
A dramatic representation of immunological cooperative events
F. Celada, A. Lanzavecchia
in Int Arch Allergy Appl Immunol (1985) vol. 76 Suppl 1 pp28-33
In vitro synthesis of human IgE: reappraisal of a 5-year study
M. Ricci, G. F. Del Prete, E. Maggi, A. Lanzavecchia, P. G. Sala, S. Romagnani
in Int Arch Allergy Appl Immunol (1985) vol. 77 pp32-7
In vitro stimulation of IgE production at a single precursor level by human alloreactive T helper clones
A. Lanzavecchia, B. Parodi
in Clin Exp Immunol (1984) vol. 55 pp197-203
The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors
D. Ramarli, B. Parodi, M. Fabbi, G. Corte, A. Lanzavecchia
in J Exp Med (1984) vol. 159 pp318-23
One out of five peripheral blood B lymphocytes is activated to high-rate Ig production by human alloreactive T cell clones
A. Lanzavecchia
in Eur J Immunol (1983) vol. 13 pp820-4
Activation of human B lymphocytes: frequency of antigen-specific B cells triggered by alloreactive or by antigen-specific T cell clones
A. Lanzavecchia, B. Parodi, F. Celada
in Eur J Immunol (1983) vol. 13 pp733-8
In vitro selective expansion of allergen specific T cells from atopic patients
A. Lanzavecchia, P. Santini, E. Maggi, G. F. Del Prete, P. Falagiani, S. Romagnani, M. Ferrarini
in Clin Exp Immunol (1983) vol. 52 pp21-8
Human T cell lines with antigen specificity and helper activity
A. Lanzavecchia, M. Ferrarini, F. Celada
in Eur J Immunol (1982) vol. 12 pp468-74
Ontogeny of secretory immunity: levels of secretory IgA and natural antibodies in saliva
G. R. Burgio, A. Lanzavecchia, A. Plebani, S. Jayakar, A. G. Ugazio
in Pediatr Res (1980) vol. 14 pp1111-4
Activation of human peripheral blood lymphocytes: effect of concanavalin A and lipopolysaccharide on in vitro synthesis of DNA and immunoglobulins
L. Nespoli, A. Vitiello, R. Maccario, A. Lanzavecchia, A. G. Ugazio
in Scand J Immunol (1980) vol. 12 pp165-70
Concanavalin A induces a T-cell dependent activation of human tonsil B cells in vitro
A. Vitiello, L. Nespoli, A. Lanzavecchia, R. Maccario, A. G. Ugazio
in Thymus (1980) vol. 1 pp215-23
Effect of in vitro treatment with reducing drugs on structure and function of human secretory immunoglobulin A
A. Plebani, A. Lanzavecchia, U. Forsgren, L. Magni, A. G. Ugazio, B. Ortengren, G. R. Burgio
in Infection (1979) vol. 7 pp64-6
Plaque assay with protein A-coated erythrocytes for the evaluation of human immunoglobulin-secreting cells induced by pokeweed mitogen
A. Lanzavecchia, G. Sacchi, R. Maccario, A. Vitiello, L. Nespoli, A. G. Ugazio
in Scand J Immunol (1979) vol. 10 pp297-302
Immunodeficiency in Down's syndrome. Titres of "natural" antibodies to E. coli and rabbit erythrocytes at different ages
A. G. Ugazio, A. Lanzavecchia, S. Jayakar, A. Plebani, M. Duse, G. R. Burgio
in Acta Paediatr Scand (1978) vol. 67 pp705-8
Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children
G. R. Burgio, A. Lanzavecchia, R. Maccario, A. Vitiello, A. Plebani, A. G. Ugazio
in Clin Exp Immunol (1978) vol. 33 pp298-301
Common variable immunodeficiency: long term clinical consequencies of splenectomy in a case of late-onset hypogammaglobulinaemia
A. Lanzavecchia, F. Frassoni, F. Piovella, A. Vitiello, R. Maccario, A. G. Ugazio
in Haematologica (1978) vol. 63 pp326-32
Polyclonal activation of human B lymphocytes in vitro by pokeweed mitogen: a simple technique for the simultaneous assessment of cell proliferation, generation of plasma cells, plaque-forming cells and immunoglobulin production
L. Nespoli, A. Vitiello, R. Maccario, A. Lanzavecchia, A. G. Ugazio
in Scand J Immunol (1978) vol. 8 pp489-96
Human T lymphocyte subset identification according to avidity for sheep erythrocytes and rosetting capacity with allogeneic red blood cells
A. Lanzavecchia, R. Maccario, A. Vitiello, L. Nespoli, A. G. Ugazio
in Boll Ist Sieroter Milan (1977) vol. 56 pp217-21